Sugi Variant

Sugi Variant/CRYBA4

CRYBA4 — 107 ClinVar variants

All ClinVar germline CRYBA4 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 42 flagged for review →

4 Pathogenic · 2 Likely pathogenic · 4 Conflicting · 22 Benign · 5 Benign/Likely benign · 27 Likely benign · 43 Uncertain significance

Full CRYBA4 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 42

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors agree, ClinVar conflicts 2

ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.

Predictors lean, ClinVar uncertain 27

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

Predictors split 13

The independent predictors disagree with each other — read with care.

All CRYBA4 variants

Pathogenic 4

Likely pathogenic 2

Conflicting classifications of pathogenicity 4

Benign 22

Benign/Likely benign 5

Likely benign 27

Uncertain significance 43