CSNK1A1L — 55 ClinVar variants
All ClinVar germline CSNK1A1L variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 53 flagged for review →
55 Uncertain significance
Full CSNK1A1L gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 53
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 31
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CSNK1A1L p.Arg200Cys Uncertain significance Single submitter
- CSNK1A1L p.Arg21Gln Uncertain significance Single submitter
- CSNK1A1L p.Arg225Thr Uncertain significance Single submitter
- CSNK1A1L p.Asn151Ser Uncertain significance Single submitter
- CSNK1A1L p.Asp84Gly Uncertain significance Single submitter
- CSNK1A1L p.Gln307Glu Uncertain significance Single submitter
- CSNK1A1L p.Gln315His Uncertain significance Single submitter
- CSNK1A1L p.Gln81Arg Uncertain significance Single submitter
- CSNK1A1L p.Gln81Lys Uncertain significance Single submitter
- CSNK1A1L p.Glu270Lys Uncertain significance Single submitter
- CSNK1A1L p.Gly159Cys Uncertain significance Single submitter
- CSNK1A1L p.Gly208Ser Uncertain significance Single submitter
- CSNK1A1L p.Gly24Arg Uncertain significance Single submitter
- CSNK1A1L p.Gly314Ala Uncertain significance Single submitter
- CSNK1A1L p.Gly40Ser Uncertain significance Single submitter
- CSNK1A1L p.Gly6Val Uncertain significance Single submitter
- CSNK1A1L p.His77Tyr Uncertain significance Single submitter
- CSNK1A1L p.Leu58Met Uncertain significance Single submitter
- CSNK1A1L p.Leu93Pro Uncertain significance Single submitter
- CSNK1A1L p.Lys235Arg Uncertain significance Single submitter
- CSNK1A1L p.Met110Ile Uncertain significance Single submitter
- CSNK1A1L p.Met115Arg Uncertain significance Single submitter
- CSNK1A1L p.Ser218Asn Uncertain significance Single submitter
- CSNK1A1L p.Ser49Cys Uncertain significance Single submitter
- CSNK1A1L p.Ser5Cys Uncertain significance Single submitter
- CSNK1A1L p.Ser7Pro Uncertain significance Single submitter
- CSNK1A1L p.Thr112Ile Uncertain significance Single submitter
- CSNK1A1L p.Thr36Ala Uncertain significance Single submitter
- CSNK1A1L p.Val20Leu Uncertain significance Single submitter
- CSNK1A1L p.Val334Gly Uncertain significance Single submitter
- CSNK1A1L p.Val334Leu Uncertain significance Single submitter
Predictors split 22
The independent predictors disagree with each other — read with care.
- CSNK1A1L p.Ala310Gly Uncertain significance Single submitter
- CSNK1A1L p.Arg107Gly Uncertain significance Single submitter
- CSNK1A1L p.Arg176Gly Uncertain significance Single submitter
- CSNK1A1L p.Arg186Gly Uncertain significance Single submitter
- CSNK1A1L p.Arg282His Uncertain significance Single submitter
- CSNK1A1L p.Asp118Asn Uncertain significance Single submitter
- CSNK1A1L p.Asp140Gly Uncertain significance Single submitter
- CSNK1A1L p.Asp84His Uncertain significance Single submitter
- CSNK1A1L p.Gln171Pro Uncertain significance Single submitter
- CSNK1A1L p.Gln56Lys Uncertain significance Single submitter
- CSNK1A1L p.Glu269Lys Uncertain significance Single submitter
- CSNK1A1L p.Glu98Gln Uncertain significance Single submitter
- CSNK1A1L p.Gly15Arg Uncertain significance Single submitter
- CSNK1A1L p.Ile236Met Uncertain significance Single submitter
- CSNK1A1L p.Leu181Phe Uncertain significance Single submitter
- CSNK1A1L p.Leu19Arg Uncertain significance Single submitter
- CSNK1A1L p.Leu280Gln Uncertain significance Single submitter
- CSNK1A1L p.Leu67Phe Uncertain significance Single submitter
- CSNK1A1L p.Lys53Thr Uncertain significance Single submitter
- CSNK1A1L p.Met204Val Uncertain significance Single submitter
- CSNK1A1L p.Ser199Thr Uncertain significance Single submitter
- CSNK1A1L p.Tyr175Cys Uncertain significance Single submitter
All CSNK1A1L variants
Uncertain significance 55
- p.Ala310Gly Single submitter ⚠
- p.Arg107Gly Single submitter ⚠
- p.Arg135Gln Single submitter
- p.Arg176Gly Single submitter ⚠
- p.Arg186Gly Single submitter ⚠
- p.Arg200Cys Single submitter ⚠
- p.Arg21Gln Single submitter ⚠
- p.Arg225Thr Single submitter ⚠
- p.Arg282His Single submitter ⚠
- p.Asn151Ser Single submitter ⚠
- p.Asp118Asn Single submitter ⚠
- p.Asp140Gly Single submitter ⚠
- p.Asp84Gly Single submitter ⚠
- p.Asp84His Single submitter ⚠
- p.Gln171Pro Single submitter ⚠
- p.Gln307Glu Single submitter ⚠
- p.Gln315His Single submitter ⚠
- p.Gln56Lys Single submitter ⚠
- p.Gln81Arg Single submitter ⚠
- p.Gln81Lys Single submitter ⚠
- p.Glu269Lys Single submitter ⚠
- p.Glu270Lys Single submitter ⚠
- p.Glu98Gln Single submitter ⚠
- p.Gly159Cys Single submitter ⚠
- p.Gly15Arg Single submitter ⚠
- p.Gly208Ser Single submitter ⚠
- p.Gly24Arg Single submitter ⚠
- p.Gly314Ala Single submitter ⚠
- p.Gly40Ser Single submitter ⚠
- p.Gly6Val Single submitter ⚠
- p.His77Tyr Single submitter ⚠
- p.Ile236Met Single submitter ⚠
- p.Leu181Phe Single submitter ⚠
- p.Leu19Arg Single submitter ⚠
- p.Leu280Gln Single submitter ⚠
- p.Leu58Met Single submitter ⚠
- p.Leu67Phe Single submitter ⚠
- p.Leu93Pro Single submitter ⚠
- p.Lys235Arg Single submitter ⚠
- p.Lys53Thr Single submitter ⚠
- p.Met110Ile Single submitter ⚠
- p.Met115Arg Single submitter ⚠
- p.Met204Val Single submitter ⚠
- p.Ser199Thr Single submitter ⚠
- p.Ser218Asn Single submitter ⚠
- p.Ser49Cys Single submitter ⚠
- p.Ser5Cys Single submitter ⚠
- p.Ser7Pro Single submitter ⚠
- p.Thr112Ile Single submitter ⚠
- p.Thr36Ala Single submitter ⚠
- p.Tyr126His Single submitter
- p.Tyr175Cys Single submitter ⚠
- p.Val20Leu Single submitter ⚠
- p.Val334Gly Single submitter ⚠
- p.Val334Leu Single submitter ⚠