CSRNP2 — 69 ClinVar variants
All ClinVar germline CSRNP2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 68 flagged for review →
1 Likely benign · 68 Uncertain significance
Full CSRNP2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 68
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 43
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CSRNP2 p.Ala289Thr Uncertain significance Single submitter
- CSRNP2 p.Arg184Gln Uncertain significance Single submitter
- CSRNP2 p.Arg282Gln Uncertain significance Single submitter
- CSRNP2 p.Arg286Leu Uncertain significance Single submitter
- CSRNP2 p.Arg511Cys Uncertain significance Single submitter
- CSRNP2 p.Arg511His Uncertain significance Single submitter
- CSRNP2 p.Arg62Gln Uncertain significance Single submitter
- CSRNP2 p.Arg63Lys Uncertain significance Single submitter
- CSRNP2 p.Asn42Ser Uncertain significance Single submitter
- CSRNP2 p.Asp498Val Uncertain significance Single submitter
- CSRNP2 p.Cys244Arg Uncertain significance Single submitter
- CSRNP2 p.Cys251Tyr Uncertain significance Single submitter
- CSRNP2 p.Gln311Arg Uncertain significance Single submitter
- CSRNP2 p.Gln70Arg Uncertain significance Single submitter
- CSRNP2 p.Glu315Asp Uncertain significance Single submitter
- CSRNP2 p.Glu438Gly Uncertain significance Single submitter
- CSRNP2 p.Glu538Gln Uncertain significance Single submitter
- CSRNP2 p.Gly435Ala Uncertain significance Single submitter
- CSRNP2 p.Gly439Arg Uncertain significance Single submitter
- CSRNP2 p.Gly476Arg Uncertain significance Single submitter
- CSRNP2 p.Gly519Arg Uncertain significance Single submitter
- CSRNP2 p.Ile258Thr Uncertain significance Single submitter
- CSRNP2 p.Ile263Val Uncertain significance Single submitter
- CSRNP2 p.Leu508Val Uncertain significance Single submitter
- CSRNP2 p.Lys181Glu Uncertain significance Single submitter
- CSRNP2 p.Met254Val Uncertain significance Single submitter
- CSRNP2 p.Phe510Ser Uncertain significance Single submitter
- CSRNP2 p.Pro287Ser Uncertain significance Single submitter
- CSRNP2 p.Pro290Ala Uncertain significance Single submitter
- CSRNP2 p.Pro290Ser Uncertain significance Single submitter
- CSRNP2 p.Pro401Arg Uncertain significance Single submitter
- CSRNP2 p.Pro409Ala Uncertain significance Single submitter
- CSRNP2 p.Pro43Ala Uncertain significance Single submitter
- CSRNP2 p.Pro491Thr Uncertain significance Single submitter
- CSRNP2 p.Pro505Leu Uncertain significance Single submitter
- CSRNP2 p.Pro509Ser Uncertain significance Single submitter
- CSRNP2 p.Pro531Leu Uncertain significance Single submitter
- CSRNP2 p.Pro531Ser Uncertain significance Single submitter
- CSRNP2 p.Ser442Thr Uncertain significance Single submitter
- CSRNP2 p.Ser7Leu Uncertain significance Single submitter
- CSRNP2 p.Ser92Cys Uncertain significance Single submitter
- CSRNP2 p.Thr523Asn Uncertain significance Single submitter
- CSRNP2 p.Thr5Met Uncertain significance Single submitter
Predictors split 25
The independent predictors disagree with each other — read with care.
- CSRNP2 p.Ala255Val Uncertain significance Single submitter
- CSRNP2 p.Arg123Cys Uncertain significance Single submitter
- CSRNP2 p.Arg194His Uncertain significance Single submitter
- CSRNP2 p.Arg218Gln Uncertain significance Single submitter
- CSRNP2 p.Arg335Gln Uncertain significance Single submitter
- CSRNP2 p.Arg57Gln Uncertain significance Single submitter
- CSRNP2 p.Arg98Cys Uncertain significance Single submitter
- CSRNP2 p.Arg98His Uncertain significance Single submitter
- CSRNP2 p.Gln382Arg Uncertain significance Single submitter
- CSRNP2 p.Glu321Lys Uncertain significance Single submitter
- CSRNP2 p.Glu354Lys Uncertain significance Single submitter
- CSRNP2 p.Gly344Arg Uncertain significance Single submitter
- CSRNP2 p.Gly344Cys Uncertain significance Single submitter
- CSRNP2 p.Ile162Thr Uncertain significance Single submitter
- CSRNP2 p.Ile263Phe Uncertain significance Single submitter
- CSRNP2 p.Leu412Phe Uncertain significance Single submitter
- CSRNP2 p.Leu428Phe Uncertain significance Single submitter
- CSRNP2 p.Lys12Asn Uncertain significance Single submitter
- CSRNP2 p.Lys281Asn Uncertain significance Single submitter
- CSRNP2 p.Ser329Gly Uncertain significance Single submitter
- CSRNP2 p.Ser346Arg Uncertain significance Single submitter
- CSRNP2 p.Thr405Met Uncertain significance Single submitter
- CSRNP2 p.Val358Met Uncertain significance Single submitter
- CSRNP2 p.Val430Met Uncertain significance Single submitter
- CSRNP2 p.Val460Met Uncertain significance Single submitter
All CSRNP2 variants
Likely benign 1
- p.Thr405Ala Single submitter
Uncertain significance 68
- p.Ala255Val Single submitter ⚠
- p.Ala289Thr Single submitter ⚠
- p.Arg123Cys Single submitter ⚠
- p.Arg184Gln Single submitter ⚠
- p.Arg194His Single submitter ⚠
- p.Arg218Gln Single submitter ⚠
- p.Arg282Gln Single submitter ⚠
- p.Arg286Leu Single submitter ⚠
- p.Arg335Gln Single submitter ⚠
- p.Arg511Cys Single submitter ⚠
- p.Arg511His Single submitter ⚠
- p.Arg57Gln Single submitter ⚠
- p.Arg62Gln Single submitter ⚠
- p.Arg63Lys Single submitter ⚠
- p.Arg98Cys Single submitter ⚠
- p.Arg98His Single submitter ⚠
- p.Asn42Ser Single submitter ⚠
- p.Asp498Val Single submitter ⚠
- p.Cys244Arg Single submitter ⚠
- p.Cys251Tyr Single submitter ⚠
- p.Gln311Arg Single submitter ⚠
- p.Gln382Arg Single submitter ⚠
- p.Gln70Arg Single submitter ⚠
- p.Glu315Asp Single submitter ⚠
- p.Glu321Lys Single submitter ⚠
- p.Glu354Lys Single submitter ⚠
- p.Glu438Gly Single submitter ⚠
- p.Glu538Gln Single submitter ⚠
- p.Gly344Arg Single submitter ⚠
- p.Gly344Cys Single submitter ⚠
- p.Gly435Ala Single submitter ⚠
- p.Gly439Arg Single submitter ⚠
- p.Gly476Arg Single submitter ⚠
- p.Gly519Arg Single submitter ⚠
- p.Ile162Thr Single submitter ⚠
- p.Ile258Thr Single submitter ⚠
- p.Ile263Phe Single submitter ⚠
- p.Ile263Val Single submitter ⚠
- p.Leu412Phe Single submitter ⚠
- p.Leu428Phe Single submitter ⚠
- p.Leu508Val Single submitter ⚠
- p.Lys12Asn Single submitter ⚠
- p.Lys181Glu Single submitter ⚠
- p.Lys281Asn Single submitter ⚠
- p.Met254Val Single submitter ⚠
- p.Phe510Ser Single submitter ⚠
- p.Pro287Ser Single submitter ⚠
- p.Pro290Ala Single submitter ⚠
- p.Pro290Ser Single submitter ⚠
- p.Pro401Arg Single submitter ⚠
- p.Pro409Ala Single submitter ⚠
- p.Pro43Ala Single submitter ⚠
- p.Pro491Thr Single submitter ⚠
- p.Pro505Leu Single submitter ⚠
- p.Pro509Ser Single submitter ⚠
- p.Pro531Leu Single submitter ⚠
- p.Pro531Ser Single submitter ⚠
- p.Ser329Gly Single submitter ⚠
- p.Ser346Arg Single submitter ⚠
- p.Ser442Thr Single submitter ⚠
- p.Ser7Leu Single submitter ⚠
- p.Ser92Cys Single submitter ⚠
- p.Thr405Met Single submitter ⚠
- p.Thr523Asn Single submitter ⚠
- p.Thr5Met Single submitter ⚠
- p.Val358Met Single submitter ⚠
- p.Val430Met Single submitter ⚠
- p.Val460Met Single submitter ⚠