CSRP1 — 38 ClinVar variants
All ClinVar germline CSRP1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 35 flagged for review →
3 Benign · 1 Likely benign · 34 Uncertain significance
Full CSRP1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 35
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 23
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CSRP1 p.Arg118His Uncertain significance Single submitter
- CSRP1 p.Arg121Gln Uncertain significance Single submitter
- CSRP1 p.Cys10Arg Uncertain significance Single submitter
- CSRP1 p.Cys119Arg Uncertain significance Single submitter
- CSRP1 p.Cys143Arg Uncertain significance Single submitter
- CSRP1 p.Cys37Ser Uncertain significance Single submitter
- CSRP1 p.Glu117Lys Uncertain significance Single submitter
- CSRP1 p.Glu154Lys Uncertain significance Single submitter
- CSRP1 p.Gly5Arg Uncertain significance Single submitter
- CSRP1 p.Gly70Arg Uncertain significance Single submitter
- CSRP1 p.Gly70Val Uncertain significance Single submitter
- CSRP1 p.Gly72Ala Uncertain significance Single submitter
- CSRP1 p.Gly74Arg Uncertain significance Single submitter
- CSRP1 p.Ile133Thr Uncertain significance Single submitter
- CSRP1 p.Leu88Pro Uncertain significance Single submitter
- CSRP1 p.Lys178Glu Uncertain significance Single submitter
- CSRP1 p.Lys178Met Uncertain significance Single submitter
- CSRP1 p.Pro2Leu Uncertain significance Single submitter
- CSRP1 p.Ser87Leu Uncertain significance Single submitter
- CSRP1 p.Trp139Arg Uncertain significance Single submitter
- CSRP1 p.Tyr127Cys Uncertain significance Single submitter
- CSRP1 p.Tyr127His Uncertain significance Single submitter
- CSRP1 p.Tyr57Cys Uncertain significance Single submitter
Predictors split 12
The independent predictors disagree with each other — read with care.
- CSRP1 p.Ala188Val Uncertain significance Single submitter
- CSRP1 p.Arg118Cys Uncertain significance Single submitter
- CSRP1 p.Asn174Ile Uncertain significance Single submitter
- CSRP1 p.Asn28Asp Benign Single submitter
- CSRP1 p.Asn43His Uncertain significance Single submitter
- CSRP1 p.Gln111Leu Uncertain significance Single submitter
- CSRP1 p.Gln124His Uncertain significance Single submitter
- CSRP1 p.Gln24Pro Uncertain significance Single submitter
- CSRP1 p.Pro120Leu Uncertain significance Single submitter
- CSRP1 p.Thr102Ile Uncertain significance Single submitter
- CSRP1 p.Thr16Met Uncertain significance Single submitter
- CSRP1 p.Val51Met Uncertain significance Single submitter
All CSRP1 variants
Benign 3
- p.Ala129= Multiple submitters
- p.Tyr62= Multiple submitters
- p.Asn28Asp Single submitter ⚠
Likely benign 1
- p.Asn105= Single submitter
Uncertain significance 34
- p.Ala188Val Single submitter ⚠
- p.Arg118Cys Single submitter ⚠
- p.Arg118His Single submitter ⚠
- p.Arg121Gln Single submitter ⚠
- p.Asn174Ile Single submitter ⚠
- p.Asn43His Single submitter ⚠
- p.Cys10Arg Single submitter ⚠
- p.Cys119Arg Single submitter ⚠
- p.Cys143Arg Single submitter ⚠
- p.Cys37Ser Single submitter ⚠
- p.Gln111Leu Single submitter ⚠
- p.Gln124His Single submitter ⚠
- p.Gln24Pro Single submitter ⚠
- p.Glu117Lys Single submitter ⚠
- p.Glu154Lys Single submitter ⚠
- p.Gly5Arg Single submitter ⚠
- p.Gly70Arg Single submitter ⚠
- p.Gly70Val Single submitter ⚠
- p.Gly72Ala Single submitter ⚠
- p.Gly74Arg Single submitter ⚠
- p.Ile133Thr Single submitter ⚠
- p.Leu88Pro Single submitter ⚠
- p.Lys178Glu Single submitter ⚠
- p.Lys178Met Single submitter ⚠
- p.Pro120Leu Single submitter ⚠
- p.Pro2Leu Single submitter ⚠
- p.Ser87Leu Single submitter ⚠
- p.Thr102Ile Single submitter ⚠
- p.Thr16Met Single submitter ⚠
- p.Trp139Arg Single submitter ⚠
- p.Tyr127Cys Single submitter ⚠
- p.Tyr127His Single submitter ⚠
- p.Tyr57Cys Single submitter ⚠
- p.Val51Met Single submitter ⚠