CSTF2T — 90 ClinVar variants
All ClinVar germline CSTF2T variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 88 flagged for review →
3 Likely benign · 87 Uncertain significance
Full CSTF2T gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 88
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 31
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CSTF2T p.Ala417Val Uncertain significance Single submitter
- CSTF2T p.Ala5Val Uncertain significance Single submitter
- CSTF2T p.Ala615Val Uncertain significance Single submitter
- CSTF2T p.Arg413Gly Uncertain significance Single submitter
- CSTF2T p.Asn230Ile Uncertain significance Single submitter
- CSTF2T p.Cys441Ser Uncertain significance Single submitter
- CSTF2T p.Gln572Glu Uncertain significance Single submitter
- CSTF2T p.Glu126Lys Uncertain significance Single submitter
- CSTF2T p.Glu142Ala Uncertain significance Single submitter
- CSTF2T p.Glu81Ala Uncertain significance Single submitter
- CSTF2T p.Gly212Val Uncertain significance Single submitter
- CSTF2T p.Gly409Ala Uncertain significance Single submitter
- CSTF2T p.Gly60Ser Uncertain significance Single submitter
- CSTF2T p.Gly79Ala Uncertain significance Single submitter
- CSTF2T p.His196Gln Uncertain significance Single submitter
- CSTF2T p.His241Asp Uncertain significance Single submitter
- CSTF2T p.Ile201Met Uncertain significance Single submitter
- CSTF2T p.Ile314Val Uncertain significance Single submitter
- CSTF2T p.Ile483Thr Uncertain significance Single submitter
- CSTF2T p.Ile498Val Uncertain significance Single submitter
- CSTF2T p.Leu228Met Uncertain significance Single submitter
- CSTF2T p.Met286Val Uncertain significance Single submitter
- CSTF2T p.Pro114Leu Uncertain significance Single submitter
- CSTF2T p.Pro199Ser Uncertain significance Single submitter
- CSTF2T p.Pro406Thr Uncertain significance Single submitter
- CSTF2T p.Pro465Ala Uncertain significance Single submitter
- CSTF2T p.Pro478Ser Uncertain significance Single submitter
- CSTF2T p.Pro492Ser Uncertain significance Single submitter
- CSTF2T p.Ser415Pro Uncertain significance Single submitter
- CSTF2T p.Thr281Ile Uncertain significance Single submitter
- CSTF2T p.Thr346Pro Uncertain significance Single submitter
Predictors split 57
The independent predictors disagree with each other — read with care.
- CSTF2T p.Ala158Thr Uncertain significance Single submitter
- CSTF2T p.Ala422Thr Uncertain significance Single submitter
- CSTF2T p.Arg302Trp Uncertain significance Single submitter
- CSTF2T p.Arg373Cys Uncertain significance Single submitter
- CSTF2T p.Arg373His Uncertain significance Single submitter
- CSTF2T p.Arg373Ser Uncertain significance Single submitter
- CSTF2T p.Arg416Gln Uncertain significance Single submitter
- CSTF2T p.Arg421Gly Uncertain significance Single submitter
- CSTF2T p.Arg431Cys Uncertain significance Single submitter
- CSTF2T p.Asp573His Uncertain significance Single submitter
- CSTF2T p.Gln139His Uncertain significance Single submitter
- CSTF2T p.Gln152Arg Uncertain significance Single submitter
- CSTF2T p.Gln519Glu Uncertain significance Single submitter
- CSTF2T p.Gln524Lys Uncertain significance Single submitter
- CSTF2T p.Gln534His Uncertain significance Single submitter
- CSTF2T p.Gln572His Uncertain significance Single submitter
- CSTF2T p.Gln574Arg Uncertain significance Single submitter
- CSTF2T p.Gln608Lys Uncertain significance Single submitter
- CSTF2T p.Glu122Gly Uncertain significance Single submitter
- CSTF2T p.Gly214Asp Uncertain significance Single submitter
- CSTF2T p.Gly397Ser Uncertain significance Single submitter
- CSTF2T p.Gly447Arg Uncertain significance Single submitter
- CSTF2T p.Gly486Asp Uncertain significance Single submitter
- CSTF2T p.Gly507Val Uncertain significance Single submitter
- CSTF2T p.Gly510Arg Uncertain significance Single submitter
- CSTF2T p.Gly525Ala Uncertain significance Single submitter
- CSTF2T p.Gly541Val Likely benign Single submitter
- CSTF2T p.Gly542Ser Uncertain significance Single submitter
- CSTF2T p.Gly547Val Uncertain significance Single submitter
- CSTF2T p.Gly550Arg Uncertain significance Single submitter
- CSTF2T p.Ile513Val Uncertain significance Single submitter
- CSTF2T p.Leu104Phe Uncertain significance Single submitter
- CSTF2T p.Lys145Arg Uncertain significance Single submitter
- CSTF2T p.Lys248Glu Uncertain significance Single submitter
- CSTF2T p.Met144Val Uncertain significance Single submitter
- CSTF2T p.Met161Ile Uncertain significance Single submitter
- CSTF2T p.Met423Val Uncertain significance Single submitter
- CSTF2T p.Met448Arg Uncertain significance Single submitter
- CSTF2T p.Met453Val Uncertain significance Single submitter
- CSTF2T p.Met593Ile Uncertain significance Single submitter
- CSTF2T p.Met593Val Uncertain significance Single submitter
- CSTF2T p.Pro213Ser Uncertain significance Single submitter
- CSTF2T p.Pro217Ser Uncertain significance Single submitter
- CSTF2T p.Pro269Ser Uncertain significance Single submitter
- CSTF2T p.Pro282Ser Uncertain significance Single submitter
- CSTF2T p.Pro288Thr Uncertain significance Single submitter
- CSTF2T p.Pro297Ser Uncertain significance Single submitter
- CSTF2T p.Pro326Leu Uncertain significance Single submitter
- CSTF2T p.Pro362Thr Uncertain significance Single submitter
- CSTF2T p.Pro375Ser Uncertain significance Single submitter
- CSTF2T p.Pro384Thr Uncertain significance Single submitter
- CSTF2T p.Pro395Leu Uncertain significance Single submitter
- CSTF2T p.Ser3Arg Uncertain significance Single submitter
- CSTF2T p.Ser83Asn Uncertain significance Single submitter
- CSTF2T p.Thr281Ser Uncertain significance Single submitter
- CSTF2T p.Thr420Ile Uncertain significance Single submitter
- CSTF2T p.Val177Ile Uncertain significance Single submitter
All CSTF2T variants
Likely benign 3
- p.Gln240del Single submitter
- p.Gly412Ser Single submitter
- p.Gly541Val Single submitter ⚠
Uncertain significance 87
- p.Ala158Thr Single submitter ⚠
- p.Ala417Val Single submitter ⚠
- p.Ala422Thr Single submitter ⚠
- p.Ala5Val Single submitter ⚠
- p.Ala615Val Single submitter ⚠
- p.Arg302Trp Single submitter ⚠
- p.Arg373Cys Single submitter ⚠
- p.Arg373His Single submitter ⚠
- p.Arg373Ser Single submitter ⚠
- p.Arg413Gly Single submitter ⚠
- p.Arg416Gln Single submitter ⚠
- p.Arg421Gly Single submitter ⚠
- p.Arg431Cys Single submitter ⚠
- p.Asn230Ile Single submitter ⚠
- p.Asp573His Single submitter ⚠
- p.Cys441Ser Single submitter ⚠
- p.Gln139His Single submitter ⚠
- p.Gln152Arg Single submitter ⚠
- p.Gln519Glu Single submitter ⚠
- p.Gln524Lys Single submitter ⚠
- p.Gln534His Single submitter ⚠
- p.Gln572Glu Single submitter ⚠
- p.Gln572His Single submitter ⚠
- p.Gln574Arg Single submitter ⚠
- p.Gln608Lys Single submitter ⚠
- p.Glu122Gly Single submitter ⚠
- p.Glu126Lys Single submitter ⚠
- p.Glu142Ala Single submitter ⚠
- p.Glu81Ala Single submitter ⚠
- p.Gly212Val Single submitter ⚠
- p.Gly214Asp Single submitter ⚠
- p.Gly397Ser Single submitter ⚠
- p.Gly409Ala Single submitter ⚠
- p.Gly447Arg Single submitter ⚠
- p.Gly486Asp Single submitter ⚠
- p.Gly507Val Single submitter ⚠
- p.Gly510Arg Single submitter ⚠
- p.Gly525Ala Single submitter ⚠
- p.Gly542Ser Single submitter ⚠
- p.Gly547Val Single submitter ⚠
- p.Gly550Arg Single submitter ⚠
- p.Gly60Ser Single submitter ⚠
- p.Gly79Ala Single submitter ⚠
- p.His196Gln Single submitter ⚠
- p.His241Asp Single submitter ⚠
- p.Ile201Met Single submitter ⚠
- p.Ile314Val Single submitter ⚠
- p.Ile483Thr Single submitter ⚠
- p.Ile498Val Single submitter ⚠
- p.Ile513Val Single submitter ⚠
- p.Leu104Phe Single submitter ⚠
- p.Leu228Met Single submitter ⚠
- p.Lys145Arg Single submitter ⚠
- p.Lys248Glu Single submitter ⚠
- p.Met144Val Single submitter ⚠
- p.Met161Ile Single submitter ⚠
- p.Met286Val Single submitter ⚠
- p.Met423Val Single submitter ⚠
- p.Met448Arg Single submitter ⚠
- p.Met453Val Single submitter ⚠
- p.Met593Ile Single submitter ⚠
- p.Met593Val Single submitter ⚠
- p.Pro114Leu Single submitter ⚠
- p.Pro199Ser Single submitter ⚠
- p.Pro213Ser Single submitter ⚠
- p.Pro217Ser Single submitter ⚠
- p.Pro269Ser Single submitter ⚠
- p.Pro282Ser Single submitter ⚠
- p.Pro288Thr Single submitter ⚠
- p.Pro297Ser Single submitter ⚠
- p.Pro326Leu Single submitter ⚠
- p.Pro362Thr Single submitter ⚠
- p.Pro375Ser Single submitter ⚠
- p.Pro384Thr Single submitter ⚠
- p.Pro395Leu Single submitter ⚠
- p.Pro406Thr Single submitter ⚠
- p.Pro465Ala Single submitter ⚠
- p.Pro478Ser Single submitter ⚠
- p.Pro492Ser Single submitter ⚠
- p.Ser3Arg Single submitter ⚠
- p.Ser415Pro Single submitter ⚠
- p.Ser83Asn Single submitter ⚠
- p.Thr281Ile Single submitter ⚠
- p.Thr281Ser Single submitter ⚠
- p.Thr346Pro Single submitter ⚠
- p.Thr420Ile Single submitter ⚠
- p.Val177Ile Single submitter ⚠