CT45A1 — 4 ClinVar variants
All ClinVar germline CT45A1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 2 flagged for review →
2 Likely benign · 2 Uncertain significance
Full CT45A1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 2
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 1
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
Predictors split 1
The independent predictors disagree with each other — read with care.
All CT45A1 variants
Likely benign 2
- p.Arg32Ser Single submitter
- p.Ile47Thr Single submitter
Uncertain significance 2
- p.Lys56Arg Single submitter ⚠
- p.Val178Phe Single submitter ⚠