CTAGE15 — 49 ClinVar variants
All ClinVar germline CTAGE15 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 47 flagged for review →
4 Likely benign · 45 Uncertain significance
Full CTAGE15 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 47
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 29
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CTAGE15 p.Ala437Ser Uncertain significance Single submitter
- CTAGE15 p.Arg425Leu Uncertain significance Single submitter
- CTAGE15 p.Arg69Trp Uncertain significance Single submitter
- CTAGE15 p.Asn242Ser Uncertain significance Single submitter
- CTAGE15 p.Asn486Thr Uncertain significance Single submitter
- CTAGE15 p.Asp309Gly Uncertain significance Single submitter
- CTAGE15 p.Asp346Glu Uncertain significance Single submitter
- CTAGE15 p.Gln300Glu Uncertain significance Single submitter
- CTAGE15 p.Glu351Lys Uncertain significance Single submitter
- CTAGE15 p.Glu498Lys Uncertain significance Single submitter
- CTAGE15 p.Gly462Glu Uncertain significance Single submitter
- CTAGE15 p.Gly73Glu Uncertain significance Single submitter
- CTAGE15 p.His254Gln Uncertain significance Single submitter
- CTAGE15 p.His449Tyr Uncertain significance Single submitter
- CTAGE15 p.Ile338Thr Uncertain significance Single submitter
- CTAGE15 p.Ile371Thr Uncertain significance Single submitter
- CTAGE15 p.Ile386Thr Uncertain significance Single submitter
- CTAGE15 p.Lys252Arg Uncertain significance Single submitter
- CTAGE15 p.Phe248Leu Uncertain significance Single submitter
- CTAGE15 p.Phe248Ser Uncertain significance Single submitter
- CTAGE15 p.Phe248Tyr Uncertain significance Single submitter
- CTAGE15 p.Phe497Ser Uncertain significance Single submitter
- CTAGE15 p.Ser239Asn Uncertain significance Single submitter
- CTAGE15 p.Ser251Ala Uncertain significance Single submitter
- CTAGE15 p.Thr287Lys Uncertain significance Single submitter
- CTAGE15 p.Thr348Lys Uncertain significance Single submitter
- CTAGE15 p.Thr493Ile Uncertain significance Single submitter
- CTAGE15 p.Tyr408His Uncertain significance Single submitter
- CTAGE15 p.Val419Glu Uncertain significance Single submitter
Predictors split 18
The independent predictors disagree with each other — read with care.
- CTAGE15 p.Arg425Cys Uncertain significance Single submitter
- CTAGE15 p.Arg470Gln Likely benign Single submitter
- CTAGE15 p.Arg470Trp Uncertain significance Single submitter
- CTAGE15 p.Asn394Asp Uncertain significance Single submitter
- CTAGE15 p.Asp211His Uncertain significance Single submitter
- CTAGE15 p.Glu232Lys Uncertain significance Single submitter
- CTAGE15 p.Glu421Lys Likely benign Single submitter
- CTAGE15 p.Glu442Val Uncertain significance Single submitter
- CTAGE15 p.Glu443Gly Uncertain significance Single submitter
- CTAGE15 p.Glu459Lys Uncertain significance Single submitter
- CTAGE15 p.Glu473Lys Uncertain significance Single submitter
- CTAGE15 p.Leu213Phe Uncertain significance Single submitter
- CTAGE15 p.Lys159Glu Uncertain significance Single submitter
- CTAGE15 p.Lys481Asn Uncertain significance Single submitter
- CTAGE15 p.Met276Lys Uncertain significance Single submitter
- CTAGE15 p.Met276Thr Uncertain significance Single submitter
- CTAGE15 p.Phe198Leu Uncertain significance Single submitter
- CTAGE15 p.Val419Gly Uncertain significance Single submitter
All CTAGE15 variants
Likely benign 4
- p.Ala519Ser Single submitter
- p.Arg425His Single submitter
- p.Arg470Gln Single submitter ⚠
- p.Glu421Lys Single submitter ⚠
Uncertain significance 45
- p.Ala437Ser Single submitter ⚠
- p.Arg425Cys Single submitter ⚠
- p.Arg425Leu Single submitter ⚠
- p.Arg470Trp Single submitter ⚠
- p.Arg69Trp Single submitter ⚠
- p.Asn242Ser Single submitter ⚠
- p.Asn394Asp Single submitter ⚠
- p.Asn486Thr Single submitter ⚠
- p.Asp211His Single submitter ⚠
- p.Asp309Gly Single submitter ⚠
- p.Asp346Glu Single submitter ⚠
- p.Gln300Glu Single submitter ⚠
- p.Glu232Lys Single submitter ⚠
- p.Glu351Lys Single submitter ⚠
- p.Glu442Val Single submitter ⚠
- p.Glu443Gly Single submitter ⚠
- p.Glu459Lys Single submitter ⚠
- p.Glu473Lys Single submitter ⚠
- p.Glu498Lys Single submitter ⚠
- p.Gly462Glu Single submitter ⚠
- p.Gly73Glu Single submitter ⚠
- p.His254Gln Single submitter ⚠
- p.His449Tyr Single submitter ⚠
- p.Ile338Thr Single submitter ⚠
- p.Ile371Thr Single submitter ⚠
- p.Ile386Thr Single submitter ⚠
- p.Leu213Phe Single submitter ⚠
- p.Lys159Glu Single submitter ⚠
- p.Lys252Arg Single submitter ⚠
- p.Lys481Asn Single submitter ⚠
- p.Met276Lys Single submitter ⚠
- p.Met276Thr Single submitter ⚠
- p.Phe198Leu Single submitter ⚠
- p.Phe248Leu Single submitter ⚠
- p.Phe248Ser Single submitter ⚠
- p.Phe248Tyr Single submitter ⚠
- p.Phe497Ser Single submitter ⚠
- p.Ser239Asn Single submitter ⚠
- p.Ser251Ala Single submitter ⚠
- p.Thr287Lys Single submitter ⚠
- p.Thr348Lys Single submitter ⚠
- p.Thr493Ile Single submitter ⚠
- p.Tyr408His Single submitter ⚠
- p.Val419Glu Single submitter ⚠
- p.Val419Gly Single submitter ⚠