CTNNAL1 — 84 ClinVar variants
All ClinVar germline CTNNAL1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 73 flagged for review →
2 Benign · 3 Likely benign · 79 Uncertain significance
Full CTNNAL1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 73
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 60
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CTNNAL1 p.Ala376Thr Uncertain significance Single submitter
- CTNNAL1 p.Ala8Ser Uncertain significance Single submitter
- CTNNAL1 p.Ala8Thr Uncertain significance Single submitter
- CTNNAL1 p.Arg161Gln Uncertain significance Single submitter
- CTNNAL1 p.Arg264Cys Uncertain significance Single submitter
- CTNNAL1 p.Arg328Leu Uncertain significance Single submitter
- CTNNAL1 p.Arg452Gln Uncertain significance Single submitter
- CTNNAL1 p.Arg530Gln Uncertain significance Single submitter
- CTNNAL1 p.Asn185Ser Uncertain significance Single submitter
- CTNNAL1 p.Asn257Ile Uncertain significance Single submitter
- CTNNAL1 p.Asn391Lys Uncertain significance Single submitter
- CTNNAL1 p.Asp27His Uncertain significance Single submitter
- CTNNAL1 p.Asp407Val Uncertain significance Single submitter
- CTNNAL1 p.Asp558Asn Uncertain significance Single submitter
- CTNNAL1 p.Asp62Gly Uncertain significance Single submitter
- CTNNAL1 p.Asp650Glu Uncertain significance Single submitter
- CTNNAL1 p.Asp687Asn Uncertain significance Single submitter
- CTNNAL1 p.Gln368Glu Uncertain significance Single submitter
- CTNNAL1 p.Gln589His Uncertain significance Single submitter
- CTNNAL1 p.Gln642Arg Uncertain significance Single submitter
- CTNNAL1 p.Gln671Arg Uncertain significance Single submitter
- CTNNAL1 p.Glu252Lys Uncertain significance Single submitter
- CTNNAL1 p.Glu377Lys Uncertain significance Single submitter
- CTNNAL1 p.Glu532Gly Uncertain significance Single submitter
- CTNNAL1 p.Gly11Ala Uncertain significance Single submitter
- CTNNAL1 p.Gly29Arg Uncertain significance Single submitter
- CTNNAL1 p.Gly9Ser Uncertain significance Single submitter
- CTNNAL1 p.His125Arg Uncertain significance Single submitter
- CTNNAL1 p.His125Asn Uncertain significance Single submitter
- CTNNAL1 p.His342Arg Uncertain significance Single submitter
- CTNNAL1 p.His469Arg Uncertain significance Single submitter
- CTNNAL1 p.Ile100Val Uncertain significance Single submitter
- CTNNAL1 p.Ile325Val Uncertain significance Single submitter
- CTNNAL1 p.Ile481Val Uncertain significance Single submitter
- CTNNAL1 p.Ile482Val Uncertain significance Single submitter
- CTNNAL1 p.Ile565Thr Uncertain significance Single submitter
- CTNNAL1 p.Ile583Thr Uncertain significance Single submitter
- CTNNAL1 p.Ile89Thr Uncertain significance Single submitter
- CTNNAL1 p.Ile89Val Uncertain significance Single submitter
- CTNNAL1 p.Leu390Phe Uncertain significance Single submitter
- CTNNAL1 p.Leu409Ile Uncertain significance Single submitter
- CTNNAL1 p.Leu453Ser Uncertain significance Single submitter
- CTNNAL1 p.Leu549Gln Uncertain significance Single submitter
- CTNNAL1 p.Leu637Phe Uncertain significance Single submitter
- CTNNAL1 p.Leu666Val Uncertain significance Single submitter
- CTNNAL1 p.Leu684Val Uncertain significance Single submitter
- CTNNAL1 p.Lys256Glu Uncertain significance Single submitter
- CTNNAL1 p.Lys271Glu Uncertain significance Single submitter
- CTNNAL1 p.Lys385Gln Uncertain significance Single submitter
- CTNNAL1 p.Lys422Glu Uncertain significance Single submitter
- CTNNAL1 p.Lys422Thr Uncertain significance Single submitter
- CTNNAL1 p.Met697Val Uncertain significance Single submitter
- CTNNAL1 p.Pro281Leu Uncertain significance Single submitter
- CTNNAL1 p.Ser28Thr Uncertain significance Single submitter
- CTNNAL1 p.Ser538Pro Uncertain significance Single submitter
- CTNNAL1 p.Thr121Asn Uncertain significance Single submitter
- CTNNAL1 p.Thr351Ile Uncertain significance Single submitter
- CTNNAL1 p.Thr424Ala Uncertain significance Single submitter
- CTNNAL1 p.Thr638Ile Uncertain significance Single submitter
- CTNNAL1 p.Val641Gly Uncertain significance Single submitter
Predictors split 13
The independent predictors disagree with each other — read with care.
- CTNNAL1 p.Arg70Cys Uncertain significance Single submitter
- CTNNAL1 p.Glu274Lys Uncertain significance Single submitter
- CTNNAL1 p.Glu38Asp Uncertain significance Single submitter
- CTNNAL1 p.Ile32Thr Uncertain significance Single submitter
- CTNNAL1 p.Leu30Pro Uncertain significance Single submitter
- CTNNAL1 p.Leu51Phe Uncertain significance Single submitter
- CTNNAL1 p.Lys154Glu Uncertain significance Single submitter
- CTNNAL1 p.Met603Arg Uncertain significance Single submitter
- CTNNAL1 p.Phe683Leu Uncertain significance Single submitter
- CTNNAL1 p.Pro665Leu Uncertain significance Single submitter
- CTNNAL1 p.Ser186Gly Uncertain significance Single submitter
- CTNNAL1 p.Thr244Ala Uncertain significance Single submitter
- CTNNAL1 p.Thr277Ile Uncertain significance Single submitter
All CTNNAL1 variants
Benign 2
- p.Thr424Ser Multiple submitters
- c.1189-17CA[4] Single submitter
Likely benign 3
- p.Arg70His Single submitter
- p.Leu175= Single submitter
- p.Val174= Single submitter
Uncertain significance 79
- p.Ala376Thr Single submitter ⚠
- p.Ala8Ser Single submitter ⚠
- p.Ala8Thr Single submitter ⚠
- p.Arg161Gln Single submitter ⚠
- p.Arg171Gly Single submitter
- p.Arg264Cys Single submitter ⚠
- p.Arg328Leu Single submitter ⚠
- p.Arg452Gln Single submitter ⚠
- p.Arg530Gln Single submitter ⚠
- p.Arg70Cys Single submitter ⚠
- p.Asn185Ser Single submitter ⚠
- p.Asn257Ile Single submitter ⚠
- p.Asn391Lys Single submitter ⚠
- p.Asp27His Single submitter ⚠
- p.Asp407Val Single submitter ⚠
- p.Asp502His Single submitter
- p.Asp558Asn Single submitter ⚠
- p.Asp62Gly Single submitter ⚠
- p.Asp650Glu Single submitter ⚠
- p.Asp687Asn Single submitter ⚠
- p.Gln368Glu Single submitter ⚠
- p.Gln589His Single submitter ⚠
- p.Gln642Arg Single submitter ⚠
- p.Gln671Arg Single submitter ⚠
- p.Glu252Lys Single submitter ⚠
- p.Glu274Lys Single submitter ⚠
- p.Glu377Lys Single submitter ⚠
- p.Glu38Asp Single submitter ⚠
- p.Glu532Gly Single submitter ⚠
- p.Gly11Ala Single submitter ⚠
- p.Gly29Arg Single submitter ⚠
- p.Gly9Ser Single submitter ⚠
- p.His125Arg Single submitter ⚠
- p.His125Asn Single submitter ⚠
- p.His342Arg Single submitter ⚠
- p.His456Arg Single submitter
- p.His469Arg Single submitter ⚠
- p.Ile100Val Single submitter ⚠
- p.Ile325Val Single submitter ⚠
- p.Ile32Thr Single submitter ⚠
- p.Ile481Val Single submitter ⚠
- p.Ile482Val Single submitter ⚠
- p.Ile565Thr Single submitter ⚠
- p.Ile583Thr Single submitter ⚠
- p.Ile593Asn Single submitter
- p.Ile89Thr Single submitter ⚠
- p.Ile89Val Single submitter ⚠
- p.Leu30Pro Single submitter ⚠
- p.Leu390Phe Single submitter ⚠
- p.Leu409Ile Single submitter ⚠
- p.Leu433Trp Single submitter
- p.Leu453Ser Single submitter ⚠
- p.Leu51Phe Single submitter ⚠
- p.Leu549Gln Single submitter ⚠
- p.Leu637Phe Single submitter ⚠
- p.Leu666Val Single submitter ⚠
- p.Leu684Val Single submitter ⚠
- p.Lys154Glu Single submitter ⚠
- p.Lys256Glu Single submitter ⚠
- p.Lys271Glu Single submitter ⚠
- p.Lys385Gln Single submitter ⚠
- p.Lys422Glu Single submitter ⚠
- p.Lys422Thr Single submitter ⚠
- p.Met603Arg Single submitter ⚠
- p.Met697Val Single submitter ⚠
- p.Phe683Leu Single submitter ⚠
- p.Pro281Leu Single submitter ⚠
- p.Pro665Leu Single submitter ⚠
- p.Ser186Gly Single submitter ⚠
- p.Ser28Thr Single submitter ⚠
- p.Ser538Pro Single submitter ⚠
- p.Thr121Asn Single submitter ⚠
- p.Thr244Ala Single submitter ⚠
- p.Thr277Ile Single submitter ⚠
- p.Thr351Ile Single submitter ⚠
- p.Thr424Ala Single submitter ⚠
- p.Thr50Met Single submitter
- p.Thr638Ile Single submitter ⚠
- p.Val641Gly Single submitter ⚠