CYP4A22 — 77 ClinVar variants
All ClinVar germline CYP4A22 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 73 flagged for review →
4 Likely benign · 73 Uncertain significance
Full CYP4A22 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 73
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 34
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CYP4A22 p.Ala248Ser Uncertain significance Single submitter
- CYP4A22 p.Ala359Asp Uncertain significance Single submitter
- CYP4A22 p.Ala47Gly Uncertain significance Single submitter
- CYP4A22 p.Ala47Thr Uncertain significance Single submitter
- CYP4A22 p.Ala85Val Uncertain significance Single submitter
- CYP4A22 p.Arg11His Uncertain significance Single submitter
- CYP4A22 p.Arg167Gln Uncertain significance Single submitter
- CYP4A22 p.Arg381Thr Uncertain significance Single submitter
- CYP4A22 p.Arg471Gly Uncertain significance Single submitter
- CYP4A22 p.Arg505Cys Uncertain significance Single submitter
- CYP4A22 p.Asn152Ser Uncertain significance Single submitter
- CYP4A22 p.Asn421Lys Uncertain significance Single submitter
- CYP4A22 p.Asn427Asp Uncertain significance Single submitter
- CYP4A22 p.Asp293His Uncertain significance Single submitter
- CYP4A22 p.Asp517Asn Uncertain significance Single submitter
- CYP4A22 p.Gln50His Uncertain significance Single submitter
- CYP4A22 p.Glu277Asp Uncertain significance Single submitter
- CYP4A22 p.Glu378Asp Uncertain significance Single submitter
- CYP4A22 p.Gly14Asp Uncertain significance Single submitter
- CYP4A22 p.Gly388Ser Uncertain significance Single submitter
- CYP4A22 p.His343Leu Uncertain significance Single submitter
- CYP4A22 p.Ile18Thr Uncertain significance Single submitter
- CYP4A22 p.Ile242Val Uncertain significance Single submitter
- CYP4A22 p.Ile330Met Uncertain significance Single submitter
- CYP4A22 p.Ile361Thr Uncertain significance Single submitter
- CYP4A22 p.Met491Val Uncertain significance Single submitter
- CYP4A22 p.Phe236Val Uncertain significance Single submitter
- CYP4A22 p.Pro512Ala Uncertain significance Single submitter
- CYP4A22 p.Pro512Leu Uncertain significance Single submitter
- CYP4A22 p.Ser244Asn Uncertain significance Single submitter
- CYP4A22 p.Thr395Ala Uncertain significance Single submitter
- CYP4A22 p.Trp173Cys Uncertain significance Single submitter
- CYP4A22 p.Tyr100Cys Uncertain significance Single submitter
- CYP4A22 p.Val424Leu Uncertain significance Single submitter
Predictors split 39
The independent predictors disagree with each other — read with care.
- CYP4A22 p.Ala255Thr Uncertain significance Single submitter
- CYP4A22 p.Ala255Val Uncertain significance Single submitter
- CYP4A22 p.Ala446Val Uncertain significance Single submitter
- CYP4A22 p.Ala472Gly Uncertain significance Single submitter
- CYP4A22 p.Ala47Asp Uncertain significance Single submitter
- CYP4A22 p.Ala85Pro Uncertain significance Single submitter
- CYP4A22 p.Arg250Cys Uncertain significance Single submitter
- CYP4A22 p.Arg254His Uncertain significance Single submitter
- CYP4A22 p.Arg312His Uncertain significance Single submitter
- CYP4A22 p.Arg348Gln Uncertain significance Single submitter
- CYP4A22 p.Arg348Trp Uncertain significance Single submitter
- CYP4A22 p.Arg477His Uncertain significance Single submitter
- CYP4A22 p.Arg486Thr Uncertain significance Single submitter
- CYP4A22 p.Arg507Gly Uncertain significance Single submitter
- CYP4A22 p.Arg96His Uncertain significance Single submitter
- CYP4A22 p.Asn427Ser Uncertain significance Single submitter
- CYP4A22 p.Asp195Asn Uncertain significance Single submitter
- CYP4A22 p.Asp310Glu Uncertain significance Single submitter
- CYP4A22 p.Glu281Lys Uncertain significance Single submitter
- CYP4A22 p.Gly17Arg Uncertain significance Single submitter
- CYP4A22 p.Gly356Ser Uncertain significance Single submitter
- CYP4A22 p.Gly402Ala Uncertain significance Single submitter
- CYP4A22 p.Gly459Arg Uncertain significance Single submitter
- CYP4A22 p.Ile242Asn Uncertain significance Single submitter
- CYP4A22 p.Ile502Thr Uncertain significance Single submitter
- CYP4A22 p.Leu334Pro Uncertain significance Single submitter
- CYP4A22 p.Leu45Ile Uncertain significance Single submitter
- CYP4A22 p.Lys284Met Uncertain significance Single submitter
- CYP4A22 p.Met162Ile Uncertain significance Single submitter
- CYP4A22 p.Phe291Ile Uncertain significance Single submitter
- CYP4A22 p.Phe66Leu Uncertain significance Single submitter
- CYP4A22 p.Pro426Ala Uncertain significance Single submitter
- CYP4A22 p.Ser200Arg Uncertain significance Single submitter
- CYP4A22 p.Thr241Asn Uncertain significance Single submitter
- CYP4A22 p.Thr263Ile Uncertain significance Single submitter
- CYP4A22 p.Thr317Met Uncertain significance Single submitter
- CYP4A22 p.Val159Met Uncertain significance Single submitter
- CYP4A22 p.Val430Gly Uncertain significance Single submitter
- CYP4A22 p.Val495Leu Uncertain significance Single submitter
All CYP4A22 variants
Likely benign 4
- p.Arg11Leu Single submitter
- p.Arg471Thr Single submitter
- p.His68Gln Single submitter
- p.Val189Ile Single submitter
Uncertain significance 73
- p.Ala248Ser Single submitter ⚠
- p.Ala255Thr Single submitter ⚠
- p.Ala255Val Single submitter ⚠
- p.Ala359Asp Single submitter ⚠
- p.Ala446Val Single submitter ⚠
- p.Ala472Gly Single submitter ⚠
- p.Ala47Asp Single submitter ⚠
- p.Ala47Gly Single submitter ⚠
- p.Ala47Thr Single submitter ⚠
- p.Ala85Pro Single submitter ⚠
- p.Ala85Val Single submitter ⚠
- p.Arg11His Single submitter ⚠
- p.Arg167Gln Single submitter ⚠
- p.Arg250Cys Single submitter ⚠
- p.Arg254His Single submitter ⚠
- p.Arg312His Single submitter ⚠
- p.Arg348Gln Single submitter ⚠
- p.Arg348Trp Single submitter ⚠
- p.Arg381Thr Single submitter ⚠
- p.Arg471Gly Single submitter ⚠
- p.Arg477His Single submitter ⚠
- p.Arg486Thr Single submitter ⚠
- p.Arg505Cys Single submitter ⚠
- p.Arg507Gly Single submitter ⚠
- p.Arg96His Single submitter ⚠
- p.Asn152Ser Single submitter ⚠
- p.Asn421Lys Single submitter ⚠
- p.Asn427Asp Single submitter ⚠
- p.Asn427Ser Single submitter ⚠
- p.Asp195Asn Single submitter ⚠
- p.Asp293His Single submitter ⚠
- p.Asp310Glu Single submitter ⚠
- p.Asp517Asn Single submitter ⚠
- p.Gln50His Single submitter ⚠
- p.Glu277Asp Single submitter ⚠
- p.Glu281Lys Single submitter ⚠
- p.Glu378Asp Single submitter ⚠
- p.Gly14Asp Single submitter ⚠
- p.Gly17Arg Single submitter ⚠
- p.Gly356Ser Single submitter ⚠
- p.Gly388Ser Single submitter ⚠
- p.Gly402Ala Single submitter ⚠
- p.Gly459Arg Single submitter ⚠
- p.His343Leu Single submitter ⚠
- p.Ile18Thr Single submitter ⚠
- p.Ile242Asn Single submitter ⚠
- p.Ile242Val Single submitter ⚠
- p.Ile330Met Single submitter ⚠
- p.Ile361Thr Single submitter ⚠
- p.Ile502Thr Single submitter ⚠
- p.Leu334Pro Single submitter ⚠
- p.Leu45Ile Single submitter ⚠
- p.Lys284Met Single submitter ⚠
- p.Met162Ile Single submitter ⚠
- p.Met491Val Single submitter ⚠
- p.Phe236Val Single submitter ⚠
- p.Phe291Ile Single submitter ⚠
- p.Phe66Leu Single submitter ⚠
- p.Pro426Ala Single submitter ⚠
- p.Pro512Ala Single submitter ⚠
- p.Pro512Leu Single submitter ⚠
- p.Ser200Arg Single submitter ⚠
- p.Ser244Asn Single submitter ⚠
- p.Thr241Asn Single submitter ⚠
- p.Thr263Ile Single submitter ⚠
- p.Thr317Met Single submitter ⚠
- p.Thr395Ala Single submitter ⚠
- p.Trp173Cys Single submitter ⚠
- p.Tyr100Cys Single submitter ⚠
- p.Val159Met Single submitter ⚠
- p.Val424Leu Single submitter ⚠
- p.Val430Gly Single submitter ⚠
- p.Val495Leu Single submitter ⚠