CYTIP — 45 ClinVar variants
All ClinVar germline CYTIP variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 44 flagged for review →
1 Likely benign · 44 Uncertain significance
Full CYTIP gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 44
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 25
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CYTIP p.Ala23Val Uncertain significance Single submitter
- CYTIP p.Ala273Pro Uncertain significance Single submitter
- CYTIP p.Ala60Thr Uncertain significance Single submitter
- CYTIP p.Arg54Trp Uncertain significance Single submitter
- CYTIP p.Asn12Lys Uncertain significance Single submitter
- CYTIP p.Asn133His Uncertain significance Single submitter
- CYTIP p.Asn14Ser Uncertain significance Single submitter
- CYTIP p.Asp37Asn Uncertain significance Single submitter
- CYTIP p.Asp38Gly Uncertain significance Single submitter
- CYTIP p.Cys284Arg Uncertain significance Single submitter
- CYTIP p.Gln115Arg Uncertain significance Single submitter
- CYTIP p.Glu243Gly Uncertain significance Single submitter
- CYTIP p.Glu318Asp Uncertain significance Single submitter
- CYTIP p.Gly272Asp Uncertain significance Single submitter
- CYTIP p.Gly32Ser Uncertain significance Single submitter
- CYTIP p.Ile305Val Uncertain significance Single submitter
- CYTIP p.Leu163Val Uncertain significance Single submitter
- CYTIP p.Leu203Ile Uncertain significance Single submitter
- CYTIP p.Met216Thr Uncertain significance Single submitter
- CYTIP p.Pro22Leu Uncertain significance Single submitter
- CYTIP p.Pro230Ser Uncertain significance Single submitter
- CYTIP p.Pro232Leu Uncertain significance Single submitter
- CYTIP p.Thr172Met Uncertain significance Single submitter
- CYTIP p.Trp249Arg Uncertain significance Single submitter
- CYTIP p.Tyr261His Uncertain significance Single submitter
Predictors split 19
The independent predictors disagree with each other — read with care.
- CYTIP p.Arg237Trp Uncertain significance Single submitter
- CYTIP p.Arg239Gln Uncertain significance Single submitter
- CYTIP p.Arg276Gln Uncertain significance Single submitter
- CYTIP p.Arg276Trp Uncertain significance Single submitter
- CYTIP p.Arg330Gln Uncertain significance Single submitter
- CYTIP p.Arg350Cys Uncertain significance Single submitter
- CYTIP p.Arg54Gln Uncertain significance Single submitter
- CYTIP p.Arg56Gly Uncertain significance Single submitter
- CYTIP p.Gln198Arg Uncertain significance Single submitter
- CYTIP p.Glu173Lys Uncertain significance Single submitter
- CYTIP p.His349Gln Uncertain significance Single submitter
- CYTIP p.Ile114Met Uncertain significance Single submitter
- CYTIP p.Leu348Phe Uncertain significance Single submitter
- CYTIP p.Phe142Leu Uncertain significance Single submitter
- CYTIP p.Pro211His Uncertain significance Single submitter
- CYTIP p.Ser105Trp Uncertain significance Single submitter
- CYTIP p.Ser68Arg Uncertain significance Single submitter
- CYTIP p.Thr29Ile Uncertain significance Single submitter
- CYTIP p.Tyr144Cys Uncertain significance Single submitter
All CYTIP variants
Likely benign 1
- p.Ala16Val Single submitter
Uncertain significance 44
- p.Ala23Val Single submitter ⚠
- p.Ala273Pro Single submitter ⚠
- p.Ala60Thr Single submitter ⚠
- p.Arg237Trp Single submitter ⚠
- p.Arg239Gln Single submitter ⚠
- p.Arg276Gln Single submitter ⚠
- p.Arg276Trp Single submitter ⚠
- p.Arg330Gln Single submitter ⚠
- p.Arg350Cys Single submitter ⚠
- p.Arg54Gln Single submitter ⚠
- p.Arg54Trp Single submitter ⚠
- p.Arg56Gly Single submitter ⚠
- p.Asn12Lys Single submitter ⚠
- p.Asn133His Single submitter ⚠
- p.Asn14Ser Single submitter ⚠
- p.Asp37Asn Single submitter ⚠
- p.Asp38Gly Single submitter ⚠
- p.Cys284Arg Single submitter ⚠
- p.Gln115Arg Single submitter ⚠
- p.Gln198Arg Single submitter ⚠
- p.Glu173Lys Single submitter ⚠
- p.Glu243Gly Single submitter ⚠
- p.Glu318Asp Single submitter ⚠
- p.Gly272Asp Single submitter ⚠
- p.Gly32Ser Single submitter ⚠
- p.His349Gln Single submitter ⚠
- p.Ile114Met Single submitter ⚠
- p.Ile305Val Single submitter ⚠
- p.Leu163Val Single submitter ⚠
- p.Leu203Ile Single submitter ⚠
- p.Leu348Phe Single submitter ⚠
- p.Met216Thr Single submitter ⚠
- p.Phe142Leu Single submitter ⚠
- p.Pro211His Single submitter ⚠
- p.Pro22Leu Single submitter ⚠
- p.Pro230Ser Single submitter ⚠
- p.Pro232Leu Single submitter ⚠
- p.Ser105Trp Single submitter ⚠
- p.Ser68Arg Single submitter ⚠
- p.Thr172Met Single submitter ⚠
- p.Thr29Ile Single submitter ⚠
- p.Trp249Arg Single submitter ⚠
- p.Tyr144Cys Single submitter ⚠
- p.Tyr261His Single submitter ⚠