CYYR1 — 35 ClinVar variants
All ClinVar germline CYYR1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 34 flagged for review →
35 Uncertain significance
Full CYYR1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 34
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 28
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CYYR1 p.Ala3Thr Uncertain significance Single submitter
- CYYR1 p.Arg143Cys Uncertain significance Single submitter
- CYYR1 p.Asn152Lys Uncertain significance Single submitter
- CYYR1 p.Asp34Val Uncertain significance Single submitter
- CYYR1 p.Asp41Asn Uncertain significance Single submitter
- CYYR1 p.Cys126Ser Uncertain significance Single submitter
- CYYR1 p.Cys48Trp Uncertain significance Single submitter
- CYYR1 p.Glu122Gln Uncertain significance Single submitter
- CYYR1 p.Glu122Lys Uncertain significance Single submitter
- CYYR1 p.Glu124Gln Uncertain significance Single submitter
- CYYR1 p.Gly118Asp Uncertain significance Single submitter
- CYYR1 p.Gly55Arg Uncertain significance Single submitter
- CYYR1 p.Gly65Ser Uncertain significance Single submitter
- CYYR1 p.Gly75Arg Uncertain significance Single submitter
- CYYR1 p.Ile73Val Uncertain significance Single submitter
- CYYR1 p.Ile77Thr Uncertain significance Single submitter
- CYYR1 p.Leu17Ser Uncertain significance Single submitter
- CYYR1 p.Met123Thr Uncertain significance Single submitter
- CYYR1 p.Met86Thr Uncertain significance Single submitter
- CYYR1 p.Pro130Leu Uncertain significance Single submitter
- CYYR1 p.Pro4Gln Uncertain significance Single submitter
- CYYR1 p.Pro4Ser Uncertain significance Single submitter
- CYYR1 p.Ser37Thr Uncertain significance Single submitter
- CYYR1 p.Tyr125His Uncertain significance Single submitter
- CYYR1 p.Tyr23His Uncertain significance Single submitter
- CYYR1 p.Val18Leu Uncertain significance Single submitter
- CYYR1 p.Val8Leu Uncertain significance Single submitter
- CYYR1 p.Val96Met Uncertain significance Single submitter
Predictors split 6
The independent predictors disagree with each other — read with care.
- CYYR1 p.Ala64Val Uncertain significance Single submitter
- CYYR1 p.Cys31Arg Uncertain significance Single submitter
- CYYR1 p.Cys31Ser Uncertain significance Single submitter
- CYYR1 p.Pro115Leu Uncertain significance Single submitter
- CYYR1 p.Pro147Thr Uncertain significance Single submitter
- CYYR1 p.Thr101Met Uncertain significance Single submitter
All CYYR1 variants
Uncertain significance 35
- p.Ala3Thr Single submitter ⚠
- p.Ala64Val Single submitter ⚠
- p.Arg143Cys Single submitter ⚠
- p.Asn152Lys Single submitter ⚠
- p.Asp34Val Single submitter ⚠
- p.Asp41Asn Single submitter ⚠
- p.Cys126Ser Single submitter ⚠
- p.Cys27Arg Single submitter
- p.Cys31Arg Single submitter ⚠
- p.Cys31Ser Single submitter ⚠
- p.Cys48Trp Single submitter ⚠
- p.Glu122Gln Single submitter ⚠
- p.Glu122Lys Single submitter ⚠
- p.Glu124Gln Single submitter ⚠
- p.Gly118Asp Single submitter ⚠
- p.Gly55Arg Single submitter ⚠
- p.Gly65Ser Single submitter ⚠
- p.Gly75Arg Single submitter ⚠
- p.Ile73Val Single submitter ⚠
- p.Ile77Thr Single submitter ⚠
- p.Leu17Ser Single submitter ⚠
- p.Met123Thr Single submitter ⚠
- p.Met86Thr Single submitter ⚠
- p.Pro115Leu Single submitter ⚠
- p.Pro130Leu Single submitter ⚠
- p.Pro147Thr Single submitter ⚠
- p.Pro4Gln Single submitter ⚠
- p.Pro4Ser Single submitter ⚠
- p.Ser37Thr Single submitter ⚠
- p.Thr101Met Single submitter ⚠
- p.Tyr125His Single submitter ⚠
- p.Tyr23His Single submitter ⚠
- p.Val18Leu Single submitter ⚠
- p.Val8Leu Single submitter ⚠
- p.Val96Met Single submitter ⚠