DACT2 — 166 ClinVar variants

All ClinVar germline DACT2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 149 flagged for review →

1 Benign · 18 Likely benign · 147 Uncertain significance

Full DACT2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 149

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors lean, ClinVar uncertain 96

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

Predictors split 53

The independent predictors disagree with each other — read with care.

All DACT2 variants

Benign 1

p.Gly707= Single submitter

Likely benign 18

c.380-6G>A Single submitter
p.Ala225Val Single submitter
p.Ala595= Single submitter
p.Arg378Gln Single submitter
p.Gly12Ser Single submitter
p.Gly375Ser Single submitter
p.Gly399Ser Single submitter
p.Gly738Arg Single submitter
p.Phe26Leu Single submitter
p.Pro256Leu Single submitter
p.Pro321Leu Single submitter
p.Pro473= Single submitter
p.Pro473Leu Single submitter
p.Ser502Arg Single submitter
p.Thr657Ala Single submitter
p.Val255Met Single submitter ⚠
p.Val438Ala Single submitter
p.Val635Met Single submitter ⚠

Uncertain significance 147

p.Ala11Thr Single submitter ⚠
p.Ala162Thr Single submitter ⚠
p.Ala186Val Single submitter ⚠
p.Ala228Val Single submitter ⚠
p.Ala239Thr Single submitter ⚠
p.Ala283Val Single submitter ⚠
p.Ala312Thr Single submitter ⚠
p.Ala332Thr Single submitter ⚠
p.Ala361Val Single submitter ⚠
p.Ala383Thr Single submitter ⚠
p.Ala496Ser Single submitter ⚠
p.Ala524Ser Single submitter ⚠
p.Ala527Val Single submitter ⚠
p.Ala578Asp Single submitter ⚠
p.Ala589Gly Single submitter ⚠
p.Ala595Glu Single submitter ⚠
p.Ala595Val Single submitter ⚠
p.Ala655Thr Single submitter ⚠
p.Ala708Thr Single submitter ⚠
p.Ala721Val Single submitter ⚠
p.Ala725Glu Single submitter ⚠
p.Ala725Val Single submitter ⚠
p.Ala76Thr Single submitter ⚠
p.Ala77Ser Single submitter ⚠
p.Arg123Gly Single submitter ⚠
p.Arg16His Single submitter ⚠
p.Arg177Gln Single submitter ⚠
p.Arg215Ser Single submitter ⚠
p.Arg261Trp Single submitter ⚠
p.Arg270Lys Single submitter ⚠
p.Arg367Lys Single submitter ⚠
p.Arg367Ser Single submitter ⚠
p.Arg386Lys Single submitter ⚠
p.Arg44Gly Single submitter ⚠
p.Arg44Pro Single submitter ⚠
p.Arg548Trp Single submitter ⚠
p.Arg559His Single submitter ⚠
p.Arg584Trp Single submitter ⚠
p.Arg607Cys Single submitter ⚠
p.Arg608Cys Single submitter ⚠
p.Arg618Gln Single submitter ⚠
p.Arg620Cys Single submitter ⚠
p.Arg633Gly Single submitter ⚠
p.Arg647Cys Single submitter ⚠
p.Arg673Trp Single submitter ⚠
p.Arg697Gly Single submitter ⚠
p.Arg749Cys Single submitter ⚠
p.Arg86Ser Single submitter ⚠
p.Asp109Asn Single submitter ⚠
p.Asp133Asn Single submitter ⚠
p.Asp238Glu Single submitter ⚠
p.Asp468Ala Single submitter ⚠
p.Asp654Val Single submitter ⚠
p.Cys670Arg Single submitter ⚠
p.Cys670Tyr Single submitter ⚠
p.Cys713Arg Single submitter ⚠
p.Cys748Tyr Single submitter ⚠
p.Gln163His Single submitter ⚠
p.Gln247Arg Single submitter ⚠
p.Gln448His Single submitter ⚠
p.Glu193Lys Single submitter ⚠
p.Glu306Gly Single submitter ⚠
p.Glu324Lys Single submitter ⚠
p.Glu351Lys Single submitter ⚠
p.Glu389Lys Single submitter ⚠
p.Glu412Asp Single submitter ⚠
p.Glu423Lys Single submitter ⚠
p.Glu435Gly Single submitter ⚠
p.Glu563Lys Single submitter ⚠
p.Glu669Lys Single submitter ⚠
p.Glu683Lys Single submitter ⚠
p.Glu68Lys Single submitter ⚠
p.Glu704Lys Single submitter ⚠
p.Gly134Asp Single submitter ⚠
p.Gly134Ser Single submitter ⚠
p.Gly369Ala Single submitter ⚠
p.Gly391Arg Single submitter ⚠
p.Gly401Cys Single submitter ⚠
p.Gly401Ser Single submitter ⚠
p.Gly407Arg Single submitter ⚠
p.Gly407Val Single submitter ⚠
p.Gly424Asp Single submitter ⚠
p.Gly456Ala Single submitter ⚠
p.Gly684Arg Single submitter ⚠
p.Gly695Arg Single submitter ⚠
p.Gly723Arg Single submitter ⚠
p.Gly9Val Single submitter ⚠
p.His62Arg Single submitter ⚠
p.Leu245Phe Single submitter ⚠
p.Leu264Met Single submitter ⚠
p.Leu323Pro Single submitter ⚠
p.Leu379Pro Single submitter ⚠
p.Leu467Pro Single submitter ⚠
p.Leu517Val Single submitter ⚠
p.Leu566Val Single submitter ⚠
p.Lys495Glu Single submitter ⚠
p.Lys495Thr Single submitter ⚠
p.Lys498Asn Single submitter ⚠
p.Lys93Arg Single submitter ⚠
p.Met504Lys Single submitter ⚠
p.Met771Thr Single submitter ⚠
p.Phe593Ser Single submitter ⚠
p.Pro258Arg Single submitter ⚠
p.Pro287Leu Single submitter ⚠
p.Pro327Leu Single submitter ⚠
p.Pro427Leu Single submitter ⚠
p.Pro473Ala Single submitter ⚠
p.Pro481Ser Single submitter ⚠
p.Pro491Ser Single submitter ⚠
p.Pro4Arg Single submitter ⚠
p.Pro4Leu Single submitter ⚠
p.Pro514Leu Single submitter ⚠
p.Pro53Thr Single submitter ⚠
p.Pro550Gln Single submitter ⚠
p.Pro579Leu Single submitter ⚠
p.Pro61Ser Single submitter ⚠
p.Pro631Ser Single submitter ⚠
p.Pro632Ser Single submitter ⚠
p.Pro8Ser Single submitter ⚠
p.Ser104Thr Single submitter ⚠
p.Ser136Pro Single submitter ⚠
p.Ser372Asn Single submitter ⚠
p.Ser430Ile Single submitter ⚠
p.Ser502Cys Single submitter ⚠
p.Ser616Leu Single submitter ⚠
p.Ser659Asn Single submitter ⚠
p.Ser667Leu Single submitter ⚠
p.Ser686Tyr Single submitter ⚠
p.Thr211Ala Single submitter ⚠
p.Thr211Ile Single submitter ⚠
p.Thr292Ile Single submitter ⚠
p.Thr38Met Single submitter ⚠
p.Thr436Ser Single submitter ⚠
p.Thr449Ile Single submitter ⚠
p.Thr541Lys Single submitter ⚠
p.Thr657Asn Single submitter ⚠
p.Thr657Ile Single submitter ⚠
p.Thr730Ile Single submitter ⚠
p.Tyr260Asn Single submitter ⚠
p.Tyr719Cys Single submitter ⚠
p.Val184Met Single submitter ⚠
p.Val249Leu Single submitter ⚠
p.Val249Met Single submitter ⚠
p.Val272Leu Single submitter ⚠
p.Val573Ile Single submitter ⚠
p.Val720Met Single submitter ⚠
p.Val744Met Single submitter ⚠