DACT3 — 116 ClinVar variants
All ClinVar germline DACT3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 115 flagged for review →
1 Likely benign · 115 Uncertain significance
Full DACT3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 115
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 57
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- DACT3 p.Ala179Pro Uncertain significance Single submitter
- DACT3 p.Ala181Ser Uncertain significance Single submitter
- DACT3 p.Ala299Gly Uncertain significance Single submitter
- DACT3 p.Ala318Ser Uncertain significance Single submitter
- DACT3 p.Ala338Pro Uncertain significance Single submitter
- DACT3 p.Ala363Val Uncertain significance Single submitter
- DACT3 p.Ala366Pro Uncertain significance Single submitter
- DACT3 p.Ala399Ser Uncertain significance Single submitter
- DACT3 p.Ala480Val Uncertain significance Single submitter
- DACT3 p.Ala55Ser Uncertain significance Single submitter
- DACT3 p.Arg113Cys Uncertain significance Single submitter
- DACT3 p.Arg113Pro Uncertain significance Single submitter
- DACT3 p.Arg148Cys Uncertain significance Single submitter
- DACT3 p.Arg263Pro Uncertain significance Single submitter
- DACT3 p.Arg288Leu Uncertain significance Single submitter
- DACT3 p.Arg417Gly Uncertain significance Single submitter
- DACT3 p.Arg493Pro Uncertain significance Single submitter
- DACT3 p.Asp291Glu Uncertain significance Single submitter
- DACT3 p.Cys232Tyr Uncertain significance Single submitter
- DACT3 p.Gln267Pro Uncertain significance Single submitter
- DACT3 p.Gln358Glu Uncertain significance Single submitter
- DACT3 p.Gln42Arg Uncertain significance Single submitter
- DACT3 p.Gln468Arg Uncertain significance Single submitter
- DACT3 p.Gln468Glu Uncertain significance Single submitter
- DACT3 p.Glu304Gln Uncertain significance Single submitter
- DACT3 p.Glu329Asp Uncertain significance Single submitter
- DACT3 p.Glu556Gln Uncertain significance Single submitter
- DACT3 p.Gly105Arg Uncertain significance Single submitter
- DACT3 p.Gly142Ala Uncertain significance Single submitter
- DACT3 p.Gly196Arg Uncertain significance Single submitter
- DACT3 p.Gly213Arg Uncertain significance Single submitter
- DACT3 p.Gly233Arg Uncertain significance Single submitter
- DACT3 p.Gly244Ser Uncertain significance Single submitter
- DACT3 p.Gly246Arg Uncertain significance Single submitter
- DACT3 p.Gly372Ser Uncertain significance Single submitter
- DACT3 p.Gly414Ala Uncertain significance Single submitter
- DACT3 p.Gly414Ser Uncertain significance Single submitter
- DACT3 p.Gly503Ser Uncertain significance Single submitter
- DACT3 p.Gly530Arg Uncertain significance Single submitter
- DACT3 p.Gly536Arg Uncertain significance Single submitter
- DACT3 p.Gly543Arg Uncertain significance Single submitter
- DACT3 p.Gly621Cys Uncertain significance Single submitter
- DACT3 p.Leu79Arg Uncertain significance Single submitter
- DACT3 p.Lys420Arg Uncertain significance Single submitter
- DACT3 p.Met406Thr Uncertain significance Single submitter
- DACT3 p.Met52Thr Uncertain significance Single submitter
- DACT3 p.Pro248Ser Uncertain significance Single submitter
- DACT3 p.Pro279Leu Uncertain significance Single submitter
- DACT3 p.Pro290Leu Uncertain significance Single submitter
- DACT3 p.Pro314Ser Uncertain significance Single submitter
- DACT3 p.Pro371Ser Uncertain significance Single submitter
- DACT3 p.Pro442Leu Uncertain significance Single submitter
- DACT3 p.Pro504Arg Uncertain significance Single submitter
- DACT3 p.Ser186Phe Uncertain significance Single submitter
- DACT3 p.Ser271Thr Uncertain significance Single submitter
- DACT3 p.Thr628Ala Uncertain significance Single submitter
- DACT3 p.Val388Leu Uncertain significance Single submitter
Predictors split 58
The independent predictors disagree with each other — read with care.
- DACT3 p.Ala181Thr Uncertain significance Single submitter
- DACT3 p.Ala194Thr Uncertain significance Single submitter
- DACT3 p.Ala365Thr Uncertain significance Single submitter
- DACT3 p.Ala375Val Uncertain significance Single submitter
- DACT3 p.Ala436Thr Uncertain significance Single submitter
- DACT3 p.Ala462Val Uncertain significance Single submitter
- DACT3 p.Ala4Gly Uncertain significance Single submitter
- DACT3 p.Ala4Thr Uncertain significance Single submitter
- DACT3 p.Ala584Val Uncertain significance Single submitter
- DACT3 p.Arg185Gln Uncertain significance Single submitter
- DACT3 p.Arg260Pro Uncertain significance Single submitter
- DACT3 p.Arg261Cys Uncertain significance Single submitter
- DACT3 p.Arg262Leu Uncertain significance Single submitter
- DACT3 p.Arg280Trp Uncertain significance Single submitter
- DACT3 p.Arg286Cys Uncertain significance Single submitter
- DACT3 p.Arg303Gln Uncertain significance Single submitter
- DACT3 p.Arg309Cys Uncertain significance Single submitter
- DACT3 p.Arg386Leu Uncertain significance Single submitter
- DACT3 p.Arg412Cys Uncertain significance Single submitter
- DACT3 p.Arg413Cys Uncertain significance Single submitter
- DACT3 p.Arg413His Uncertain significance Single submitter
- DACT3 p.Arg419Cys Uncertain significance Single submitter
- DACT3 p.Arg458Cys Uncertain significance Single submitter
- DACT3 p.Arg459Cys Uncertain significance Single submitter
- DACT3 p.Arg477Cys Uncertain significance Single submitter
- DACT3 p.Arg512His Uncertain significance Single submitter
- DACT3 p.Asp250Asn Uncertain significance Single submitter
- DACT3 p.Asp291Asn Uncertain significance Single submitter
- DACT3 p.Asp486Asn Uncertain significance Single submitter
- DACT3 p.Asp92Tyr Uncertain significance Single submitter
- DACT3 p.Cys524Tyr Uncertain significance Single submitter
- DACT3 p.Gln82Arg Uncertain significance Single submitter
- DACT3 p.Glu523Lys Uncertain significance Single submitter
- DACT3 p.Glu60Lys Uncertain significance Single submitter
- DACT3 p.Gly139Val Uncertain significance Single submitter
- DACT3 p.Gly178Asp Uncertain significance Single submitter
- DACT3 p.Gly196Val Uncertain significance Single submitter
-
DACT3 p.Gly251Cys
Uncertain significance
Single submitter
Progressive spastic paraparesis
- DACT3 p.Gly274Asp Uncertain significance Single submitter
- DACT3 p.Gly432Cys Uncertain significance Single submitter
- DACT3 p.Gly53Arg Uncertain significance Single submitter
- DACT3 p.Gly544Asp Uncertain significance Single submitter
- DACT3 p.His31Arg Uncertain significance Single submitter
- DACT3 p.Ile253Leu Uncertain significance Single submitter
- DACT3 p.Ile253Phe Uncertain significance Single submitter
- DACT3 p.Lys420Glu Uncertain significance Single submitter
- DACT3 p.Lys600Glu Uncertain significance Single submitter
- DACT3 p.Pro218Ser Uncertain significance Single submitter
- DACT3 p.Pro268Thr Uncertain significance Single submitter
- DACT3 p.Pro272Leu Uncertain significance Single submitter
- DACT3 p.Pro340Ser Uncertain significance Single submitter
- DACT3 p.Ser115Leu Uncertain significance Single submitter
- DACT3 p.Ser143Cys Uncertain significance Single submitter
- DACT3 p.Ser204Phe Uncertain significance Single submitter
- DACT3 p.Ser239Leu Uncertain significance Single submitter
- DACT3 p.Ser391Leu Uncertain significance Single submitter
- DACT3 p.Val490Met Uncertain significance Single submitter
- DACT3 p.Val603Leu Uncertain significance Single submitter
All DACT3 variants
Likely benign 1
- p.Gly233Ser Single submitter
Uncertain significance 115
- p.Ala179Pro Single submitter ⚠
- p.Ala181Ser Single submitter ⚠
- p.Ala181Thr Single submitter ⚠
- p.Ala194Thr Single submitter ⚠
- p.Ala299Gly Single submitter ⚠
- p.Ala318Ser Single submitter ⚠
- p.Ala338Pro Single submitter ⚠
- p.Ala363Val Single submitter ⚠
- p.Ala365Thr Single submitter ⚠
- p.Ala366Pro Single submitter ⚠
- p.Ala375Val Single submitter ⚠
- p.Ala399Ser Single submitter ⚠
- p.Ala436Thr Single submitter ⚠
- p.Ala462Val Single submitter ⚠
- p.Ala480Val Single submitter ⚠
- p.Ala4Gly Single submitter ⚠
- p.Ala4Thr Single submitter ⚠
- p.Ala55Ser Single submitter ⚠
- p.Ala584Val Single submitter ⚠
- p.Arg113Cys Single submitter ⚠
- p.Arg113Pro Single submitter ⚠
- p.Arg148Cys Single submitter ⚠
- p.Arg185Gln Single submitter ⚠
- p.Arg260Pro Single submitter ⚠
- p.Arg261Cys Single submitter ⚠
- p.Arg262Leu Single submitter ⚠
- p.Arg263Pro Single submitter ⚠
- p.Arg280Trp Single submitter ⚠
- p.Arg286Cys Single submitter ⚠
- p.Arg288Leu Single submitter ⚠
- p.Arg303Gln Single submitter ⚠
- p.Arg309Cys Single submitter ⚠
- p.Arg386Leu Single submitter ⚠
- p.Arg412Cys Single submitter ⚠
- p.Arg413Cys Single submitter ⚠
- p.Arg413His Single submitter ⚠
- p.Arg417Gly Single submitter ⚠
- p.Arg419Cys Single submitter ⚠
- p.Arg458Cys Single submitter ⚠
- p.Arg459Cys Single submitter ⚠
- p.Arg477Cys Single submitter ⚠
- p.Arg493Pro Single submitter ⚠
- p.Arg512His Single submitter ⚠
- p.Asp250Asn Single submitter ⚠
- p.Asp291Asn Single submitter ⚠
- p.Asp291Glu Single submitter ⚠
- p.Asp486Asn Single submitter ⚠
- p.Asp92Tyr Single submitter ⚠
- p.Cys232Tyr Single submitter ⚠
- p.Cys524Tyr Single submitter ⚠
- p.Gln267Pro Single submitter ⚠
- p.Gln358Glu Single submitter ⚠
- p.Gln42Arg Single submitter ⚠
- p.Gln468Arg Single submitter ⚠
- p.Gln468Glu Single submitter ⚠
- p.Gln82Arg Single submitter ⚠
- p.Glu304Gln Single submitter ⚠
- p.Glu329Asp Single submitter ⚠
- p.Glu523Lys Single submitter ⚠
- p.Glu556Gln Single submitter ⚠
- p.Glu60Lys Single submitter ⚠
- p.Gly105Arg Single submitter ⚠
- p.Gly139Val Single submitter ⚠
- p.Gly142Ala Single submitter ⚠
- p.Gly178Asp Single submitter ⚠
- p.Gly196Arg Single submitter ⚠
- p.Gly196Val Single submitter ⚠
- p.Gly213Arg Single submitter ⚠
- p.Gly233Arg Single submitter ⚠
- p.Gly244Ser Single submitter ⚠
- p.Gly246Arg Single submitter ⚠
- p.Gly251Cys Single submitter Progressive spastic paraparesis ⚠
- p.Gly274Asp Single submitter ⚠
- p.Gly372Ser Single submitter ⚠
- p.Gly414Ala Single submitter ⚠
- p.Gly414Ser Single submitter ⚠
- p.Gly432Cys Single submitter ⚠
- p.Gly503Ser Single submitter ⚠
- p.Gly530Arg Single submitter ⚠
- p.Gly536Arg Single submitter ⚠
- p.Gly53Arg Single submitter ⚠
- p.Gly543Arg Single submitter ⚠
- p.Gly544Asp Single submitter ⚠
- p.Gly621Cys Single submitter ⚠
- p.His31Arg Single submitter ⚠
- p.Ile253Leu Single submitter ⚠
- p.Ile253Phe Single submitter ⚠
- p.Leu79Arg Single submitter ⚠
- p.Lys420Arg Single submitter ⚠
- p.Lys420Glu Single submitter ⚠
- p.Lys600Glu Single submitter ⚠
- p.Met406Thr Single submitter ⚠
- p.Met52Thr Single submitter ⚠
- p.Pro218Ser Single submitter ⚠
- p.Pro248Ser Single submitter ⚠
- p.Pro268Thr Single submitter ⚠
- p.Pro272Leu Single submitter ⚠
- p.Pro279Leu Single submitter ⚠
- p.Pro290Leu Single submitter ⚠
- p.Pro314Ser Single submitter ⚠
- p.Pro340Ser Single submitter ⚠
- p.Pro371Ser Single submitter ⚠
- p.Pro442Leu Single submitter ⚠
- p.Pro504Arg Single submitter ⚠
- p.Ser115Leu Single submitter ⚠
- p.Ser143Cys Single submitter ⚠
- p.Ser186Phe Single submitter ⚠
- p.Ser204Phe Single submitter ⚠
- p.Ser239Leu Single submitter ⚠
- p.Ser271Thr Single submitter ⚠
- p.Ser391Leu Single submitter ⚠
- p.Thr628Ala Single submitter ⚠
- p.Val388Leu Single submitter ⚠
- p.Val490Met Single submitter ⚠
- p.Val603Leu Single submitter ⚠