DAND5 — 29 ClinVar variants
All ClinVar germline DAND5 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 23 flagged for review →
1 Pathogenic/Likely pathogenic · 1 Benign · 4 Likely benign · 23 Uncertain significance
Full DAND5 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 23
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 9
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- DAND5 p.Ala16Val Uncertain significance Single submitter
- DAND5 p.Ala86Ser Uncertain significance Single submitter
- DAND5 p.Arg23Thr Uncertain significance Single submitter
- DAND5 p.Arg30Gln Uncertain significance Single submitter
- DAND5 p.Gln5His Uncertain significance Single submitter
- DAND5 p.Glu181Lys Uncertain significance Single submitter
- DAND5 p.Gly80Glu Uncertain significance Single submitter
- DAND5 p.Ser116Ala Uncertain significance Single submitter
- DAND5 p.Trp34Gly Uncertain significance Single submitter
Predictors split 14
The independent predictors disagree with each other — read with care.
- DAND5 p.Ala62Val Uncertain significance Single submitter
- DAND5 p.Arg112Trp Uncertain significance Single submitter
- DAND5 p.Arg119Cys Uncertain significance Single submitter
- DAND5 p.Arg152Cys Uncertain significance Single submitter
- DAND5 p.Arg152Gly Uncertain significance Single submitter
- DAND5 p.Arg154His Likely benign Single submitter
- DAND5 p.Arg79Cys Uncertain significance Single submitter
- DAND5 p.Glu95Gly Uncertain significance Single submitter
- DAND5 p.Gly136Val Uncertain significance Single submitter
- DAND5 p.Gly73Trp Uncertain significance Single submitter
- DAND5 p.Leu142Ile Uncertain significance Single submitter
- DAND5 p.Leu144Pro Uncertain significance Single submitter
- DAND5 p.Pro105Ser Uncertain significance Single submitter
- DAND5 p.Thr140Ile Uncertain significance Single submitter
All DAND5 variants
Pathogenic/Likely pathogenic 1
- p.Tyr133fs No assertion criteria Heterotaxy
Benign 1
- c.-36ACAG[2] Single submitter
Likely benign 4
- p.Arg154His Single submitter ⚠
- p.Ile175Thr Single submitter
- p.Met178Val Single submitter
- p.Ser33Pro Single submitter
Uncertain significance 23
- p.Ala16Val Single submitter ⚠
- p.Ala62Val Single submitter ⚠
- p.Ala86Ser Single submitter ⚠
- p.Arg112Trp Single submitter ⚠
- p.Arg119Cys Single submitter ⚠
- p.Arg152Cys Single submitter ⚠
- p.Arg152Gly Single submitter ⚠
- p.Arg23Thr Single submitter ⚠
- p.Arg30Gln Single submitter ⚠
- p.Arg79Cys Single submitter ⚠
- p.Gln5His Single submitter ⚠
- p.Glu181Lys Single submitter ⚠
- p.Glu95Gly Single submitter ⚠
- p.Gly136Val Single submitter ⚠
- p.Gly73Trp Single submitter ⚠
- p.Gly80Glu Single submitter ⚠
- p.Leu142Ile Single submitter ⚠
- p.Leu144Pro Single submitter ⚠
- p.Leu66fs Single submitter Heterotaxy
- p.Pro105Ser Single submitter ⚠
- p.Ser116Ala Single submitter ⚠
- p.Thr140Ile Single submitter ⚠
- p.Trp34Gly Single submitter ⚠