DAZAP2 — 33 ClinVar variants
All ClinVar germline DAZAP2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 23 flagged for review →
6 Likely benign · 27 Uncertain significance
Full DAZAP2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 23
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 15
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- DAZAP2 p.Ala79Thr Uncertain significance Single submitter
- DAZAP2 p.Asn146Thr Uncertain significance Single submitter
- DAZAP2 p.Ile87Val Uncertain significance Single submitter
- DAZAP2 p.Ile97Met Uncertain significance Single submitter
- DAZAP2 p.Leu70Val Uncertain significance Single submitter
- DAZAP2 p.Pro130Thr Uncertain significance Single submitter
- DAZAP2 p.Pro17Ser Uncertain significance Single submitter
- DAZAP2 p.Pro73Leu Uncertain significance Single submitter
- DAZAP2 p.Ser49Thr Uncertain significance Single submitter
- DAZAP2 p.Tyr13Cys Uncertain significance Single submitter
- DAZAP2 p.Tyr46Cys Uncertain significance Single submitter
- DAZAP2 p.Val147Phe Uncertain significance Single submitter
- DAZAP2 p.Val149Ile Uncertain significance Single submitter
- DAZAP2 p.Val149Leu Uncertain significance Single submitter
- DAZAP2 p.Val22Ala Uncertain significance Single submitter
Predictors split 8
The independent predictors disagree with each other — read with care.
- DAZAP2 p.Arg47Gly Uncertain significance Single submitter
- DAZAP2 p.Asn146Ser Likely benign Single submitter
- DAZAP2 p.Gly19Glu Uncertain significance Single submitter
- DAZAP2 p.Gly67Glu Uncertain significance Single submitter
- DAZAP2 p.Pro133Leu Likely benign Single submitter
- DAZAP2 p.Pro133Ser Uncertain significance Single submitter
- DAZAP2 p.Ser3Thr Uncertain significance Single submitter
- DAZAP2 p.Val51Glu Uncertain significance Single submitter
All DAZAP2 variants
Likely benign 6
- p.Ala137Val Single submitter
- p.Asn146= Single submitter
- p.Asn146Ser Single submitter ⚠
- p.Leu148= Single submitter
- p.Pro128Leu Single submitter
- p.Pro133Leu Single submitter ⚠
Uncertain significance 27
- c.*118G>A Single submitter
- c.*24G>A Single submitter
- c.*50C>G Single submitter
- c.*51T>G Single submitter
- c.*58A>G Single submitter
- c.*5C>G Single submitter
- p.Ala79Thr Single submitter ⚠
- p.Arg47Gly Single submitter ⚠
- p.Asn146Thr Single submitter ⚠
- p.Gly19Glu Single submitter ⚠
- p.Gly67Glu Single submitter ⚠
- p.Ile87Val Single submitter ⚠
- p.Ile97Met Single submitter ⚠
- p.Leu70Val Single submitter ⚠
- p.Pro130Thr Single submitter ⚠
- p.Pro133Ser Single submitter ⚠
- p.Pro17Ser Single submitter ⚠
- p.Pro73Leu Single submitter ⚠
- p.Ser3Thr Single submitter ⚠
- p.Ser49Thr Single submitter ⚠
- p.Tyr13Cys Single submitter ⚠
- p.Tyr46Cys Single submitter ⚠
- p.Val147Phe Single submitter ⚠
- p.Val149Ile Single submitter ⚠
- p.Val149Leu Single submitter ⚠
- p.Val22Ala Single submitter ⚠
- p.Val51Glu Single submitter ⚠