DBN1 — 102 ClinVar variants

All ClinVar germline DBN1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 89 flagged for review →

7 Benign · 3 Likely benign · 92 Uncertain significance

Full DBN1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 89

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors lean, ClinVar uncertain 59

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

Predictors split 30

The independent predictors disagree with each other — read with care.

All DBN1 variants

Benign 7

c.143-5C>T Single submitter
c.1914+4C>T Single submitter
p.Arg226Gln Single submitter
p.Asp39= Single submitter
p.Leu133= Single submitter
p.Pro378= Single submitter
p.Pro384= Single submitter

Likely benign 3

p.Ala489Thr Single submitter
p.Glu229= Single submitter
p.Pro563Leu Single submitter

Uncertain significance 92

c.86+1283G>A Single submitter
c.86+1286G>A Single submitter
c.86+1299A>T Single submitter
p.Ala126Val Single submitter ⚠
p.Ala244Val Single submitter ⚠
p.Ala27Thr Single submitter ⚠
p.Ala455Val Single submitter ⚠
p.Ala485Thr Single submitter ⚠
p.Ala532Thr Single submitter ⚠
p.Ala653Gly Single submitter ⚠
p.Ala653Val Single submitter ⚠
p.Ala660Pro Single submitter ⚠
p.Ala97Thr Single submitter ⚠
p.Arg139Gln Single submitter ⚠
p.Arg147Gln Single submitter ⚠
p.Arg149Gln Single submitter ⚠
p.Arg151Gln Single submitter ⚠
p.Arg174Gln Single submitter ⚠
p.Arg210Trp Single submitter ⚠
p.Arg226Trp Single submitter ⚠
p.Arg228Gln Single submitter ⚠
p.Arg372Trp Single submitter ⚠
p.Arg382Trp Single submitter ⚠
p.Arg400Gln Single submitter ⚠
p.Arg400Gly Single submitter ⚠
p.Arg458Trp Single submitter ⚠
p.Arg94His Single submitter ⚠
p.Asp113Asn Single submitter ⚠
p.Asp309Glu Single submitter ⚠
p.Asp36Glu Single submitter ⚠
p.Asp403His Single submitter ⚠
p.Asp580His Single submitter ⚠
p.Cys573Phe Single submitter ⚠
p.Gln131His Single submitter ⚠
p.Gln179Arg Single submitter ⚠
p.Gln231His Single submitter ⚠
p.Gln397His Single submitter ⚠
p.Gln74Arg Single submitter ⚠
p.Glu202Gln Single submitter ⚠
p.Glu233Lys Single submitter ⚠
p.Glu24Gly Single submitter ⚠
p.Glu263Ala Single submitter ⚠
p.Glu433Lys Single submitter ⚠
p.Glu53Asp Single submitter ⚠
p.Glu692Gly Single submitter ⚠
p.Gly136Arg Single submitter ⚠
p.Gly37Asp Single submitter ⚠
p.Gly445Ser Single submitter ⚠
p.Gly527Asp Single submitter ⚠
p.Gly537Asp Single submitter ⚠
p.Gly66Ser Single submitter ⚠
p.His235Asn Single submitter ⚠
p.His268Tyr Single submitter ⚠
p.His316Pro Single submitter ⚠
p.His9Arg Single submitter ⚠
p.Ile256Val Single submitter ⚠
p.Ile398Met Single submitter ⚠
p.Leu242Ser Single submitter ⚠
p.Leu524Pro Single submitter ⚠
p.Lys62Arg Single submitter ⚠
p.Met269Ile Single submitter ⚠
p.Met468Leu Single submitter ⚠
p.Pro376Leu Single submitter ⚠
p.Pro393Ala Single submitter ⚠
p.Pro415Gln Single submitter ⚠
p.Pro415Ser Single submitter ⚠
p.Pro463Leu Single submitter ⚠
p.Pro565Leu Single submitter ⚠
p.Pro606Ser Single submitter ⚠
p.Pro664Leu Single submitter ⚠
p.Pro665Leu Single submitter ⚠
p.Ser25Asn Single submitter ⚠
p.Ser383Arg Single submitter ⚠
p.Ser462Asn Single submitter ⚠
p.Ser46Thr Single submitter ⚠
p.Ser546Leu Single submitter ⚠
p.Ser55Ala Single submitter ⚠
p.Thr406Ser Single submitter ⚠
p.Thr503Asn Single submitter ⚠
p.Thr505Ser Single submitter ⚠
p.Thr519Ile Single submitter ⚠
p.Thr607Ser Single submitter ⚠
p.Val159Met Single submitter ⚠
p.Val310Gly Single submitter ⚠
p.Val310Leu Single submitter ⚠
p.Val477Ile Single submitter ⚠
p.Val482Met Single submitter ⚠
p.Val4Ile Single submitter ⚠
p.Val514Ile Single submitter ⚠
p.Val550Ile Single submitter ⚠
p.Val666Leu Single submitter ⚠
p.Val81Met Single submitter ⚠