DBNL — 60 ClinVar variants
All ClinVar germline DBNL variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 52 flagged for review →
8 Likely benign · 52 Uncertain significance
Full DBNL gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 52
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 23
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- DBNL p.Ala11Val Uncertain significance Single submitter
- DBNL p.Ala378Ser Uncertain significance Single submitter
- DBNL p.Ala65Thr Uncertain significance Single submitter
- DBNL p.Ala96Val Uncertain significance Single submitter
- DBNL p.Arg219His Uncertain significance Single submitter
- DBNL p.Arg248Gln Uncertain significance Single submitter
- DBNL p.Asp393Glu Uncertain significance Single submitter
- DBNL p.Gln234His Uncertain significance Single submitter
- DBNL p.Glu300Gln Uncertain significance Single submitter
- DBNL p.Glu330Gln Uncertain significance Single submitter
- DBNL p.Glu87Lys Uncertain significance Single submitter
- DBNL p.Gly153Arg Uncertain significance Single submitter
- DBNL p.Gly354Ala Uncertain significance Single submitter
- DBNL p.Gly356Ser Uncertain significance Single submitter
- DBNL p.Gly368Glu Uncertain significance Single submitter
- DBNL p.Ile360Thr Uncertain significance Single submitter
- DBNL p.Pro276Ser Uncertain significance Single submitter
- DBNL p.Pro301Ala Uncertain significance Single submitter
- DBNL p.Thr295Ala Uncertain significance Single submitter
- DBNL p.Thr295Ser Uncertain significance Single submitter
- DBNL p.Thr342Asn Uncertain significance Single submitter
- DBNL p.Tyr224His Uncertain significance Single submitter
- DBNL p.Val243Ala Uncertain significance Single submitter
Predictors split 29
The independent predictors disagree with each other — read with care.
- DBNL p.Ala156Asp Uncertain significance Single submitter
- DBNL p.Arg190His Uncertain significance Single submitter
- DBNL p.Arg191Trp Uncertain significance Single submitter
- DBNL p.Arg196Leu Uncertain significance Single submitter
- DBNL p.Arg197Trp Uncertain significance Single submitter
- DBNL p.Arg203Gln Likely benign Single submitter
- DBNL p.Arg203Trp Uncertain significance Single submitter
- DBNL p.Arg210Gln Uncertain significance Single submitter
- DBNL p.Arg212Cys Uncertain significance Single submitter
- DBNL p.Arg219Cys Uncertain significance Single submitter
- DBNL p.Arg220Trp Uncertain significance Single submitter
- DBNL p.Arg93Gln Uncertain significance Single submitter
- DBNL p.Glu199Lys Uncertain significance Single submitter
- DBNL p.Glu341Ala Uncertain significance Single submitter
- DBNL p.Glu341Lys Uncertain significance Single submitter
- DBNL p.Glu345Lys Uncertain significance Single submitter
- DBNL p.Glu406Lys Uncertain significance Single submitter
- DBNL p.Gly159Ala Uncertain significance Single submitter
- DBNL p.Ile40Met Uncertain significance Single submitter
- DBNL p.Phe149Leu Uncertain significance Single submitter
- DBNL p.Pro317Leu Likely benign Single submitter
- DBNL p.Pro322His Uncertain significance Single submitter
- DBNL p.Pro337Thr Uncertain significance Single submitter
- DBNL p.Pro347Thr Uncertain significance Single submitter
- DBNL p.Ser232Asn Uncertain significance Single submitter
- DBNL p.Ser274Phe Uncertain significance Single submitter
- DBNL p.Tyr16Cys Uncertain significance Single submitter
- DBNL p.Val174Ala Uncertain significance Single submitter
- DBNL p.Val326Met Uncertain significance Single submitter
All DBNL variants
Likely benign 8
- p.Ala318Val Single submitter
- p.Arg203Gln Single submitter ⚠
- p.Arg219Leu Single submitter
- p.Arg41= Single submitter
- p.Asp386= Single submitter
- p.Pro317Leu Single submitter ⚠
- p.Pro319= Single submitter
- p.Thr236Met Single submitter
Uncertain significance 52
- c.754-11C>T Single submitter
- c.754-15T>C Single submitter
- p.Ala11Val Single submitter ⚠
- p.Ala156Asp Single submitter ⚠
- p.Ala378Ser Single submitter ⚠
- p.Ala65Thr Single submitter ⚠
- p.Ala96Val Single submitter ⚠
- p.Arg190His Single submitter ⚠
- p.Arg191Trp Single submitter ⚠
- p.Arg196Leu Single submitter ⚠
- p.Arg197Trp Single submitter ⚠
- p.Arg203Trp Single submitter ⚠
- p.Arg210Gln Single submitter ⚠
- p.Arg212Cys Single submitter ⚠
- p.Arg219Cys Single submitter ⚠
- p.Arg219His Single submitter ⚠
- p.Arg220Trp Single submitter ⚠
- p.Arg248Gln Single submitter ⚠
- p.Arg93Gln Single submitter ⚠
- p.Asp393Glu Single submitter ⚠
- p.Gln234His Single submitter ⚠
- p.Glu199Lys Single submitter ⚠
- p.Glu300Gln Single submitter ⚠
- p.Glu330Gln Single submitter ⚠
- p.Glu341Ala Single submitter ⚠
- p.Glu341Lys Single submitter ⚠
- p.Glu345Lys Single submitter ⚠
- p.Glu406Lys Single submitter ⚠
- p.Glu87Lys Single submitter ⚠
- p.Gly153Arg Single submitter ⚠
- p.Gly159Ala Single submitter ⚠
- p.Gly354Ala Single submitter ⚠
- p.Gly356Ser Single submitter ⚠
- p.Gly368Glu Single submitter ⚠
- p.Ile360Thr Single submitter ⚠
- p.Ile40Met Single submitter ⚠
- p.Phe149Leu Single submitter ⚠
- p.Pro276Ser Single submitter ⚠
- p.Pro301Ala Single submitter ⚠
- p.Pro322His Single submitter ⚠
- p.Pro337Thr Single submitter ⚠
- p.Pro347Thr Single submitter ⚠
- p.Ser232Asn Single submitter ⚠
- p.Ser274Phe Single submitter ⚠
- p.Thr295Ala Single submitter ⚠
- p.Thr295Ser Single submitter ⚠
- p.Thr342Asn Single submitter ⚠
- p.Tyr16Cys Single submitter ⚠
- p.Tyr224His Single submitter ⚠
- p.Val174Ala Single submitter ⚠
- p.Val243Ala Single submitter ⚠
- p.Val326Met Single submitter ⚠