DBP — 45 ClinVar variants
All ClinVar germline DBP variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 41 flagged for review →
1 Benign · 3 Likely benign · 41 Uncertain significance
Full DBP gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 41
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 25
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- DBP p.Ala171Ser Uncertain significance Single submitter
- DBP p.Ala324Thr Uncertain significance Single submitter
- DBP p.Ala96Ser Uncertain significance Single submitter
- DBP p.Arg146Leu Uncertain significance Single submitter
- DBP p.Arg163Gly Uncertain significance Single submitter
- DBP p.Arg226Gln Uncertain significance Single submitter
- DBP p.Arg305Ser Uncertain significance Single submitter
- DBP p.Asp113Asn Uncertain significance Single submitter
- DBP p.Cys47Tyr Uncertain significance Single submitter
- DBP p.Glu53Asp Uncertain significance Single submitter
- DBP p.Gly158Ser Uncertain significance Single submitter
- DBP p.Gly176Arg Uncertain significance Single submitter
- DBP p.Gly79Val Uncertain significance Single submitter
- DBP p.Leu15Val Uncertain significance Single submitter
- DBP p.Leu34Val Uncertain significance Single submitter
- DBP p.Pro10Leu Uncertain significance Single submitter
- DBP p.Pro110Ser Uncertain significance Single submitter
- DBP p.Pro239Arg Uncertain significance Single submitter
- DBP p.Pro23Arg Uncertain significance Single submitter
- DBP p.Pro59Arg Uncertain significance Single submitter
- DBP p.Pro59Leu Uncertain significance Single submitter
- DBP p.Pro93Ser Uncertain significance Single submitter
- DBP p.Pro95Ala Uncertain significance Single submitter
- DBP p.Ser260Asn Uncertain significance Single submitter
- DBP p.Thr63Pro Uncertain significance Single submitter
Predictors split 16
The independent predictors disagree with each other — read with care.
- DBP p.Ala149Val Uncertain significance Single submitter
- DBP p.Ala96Thr Uncertain significance Single submitter
- DBP p.Arg188Gln Uncertain significance Single submitter
- DBP p.Arg188Trp Uncertain significance Single submitter
- DBP p.Arg229Cys Uncertain significance Single submitter
- DBP p.Glu221Lys Uncertain significance Single submitter
- DBP p.Gly155Asp Uncertain significance Single submitter
- DBP p.Gly180Cys Uncertain significance Single submitter
- DBP p.His228Arg Uncertain significance Single submitter
- DBP p.Ile240Val Uncertain significance Single submitter
- DBP p.Leu296Met Uncertain significance Single submitter
- DBP p.Pro110Leu Uncertain significance Single submitter
- DBP p.Pro134Thr Uncertain significance Single submitter
- DBP p.Pro142Leu Uncertain significance Single submitter
- DBP p.Thr186Ile Uncertain significance Single submitter
- DBP p.Val199Met Uncertain significance Single submitter
All DBP variants
Benign 1
- p.Val304= Multiple submitters
Likely benign 3
- p.Gly24Ser Multiple submitters
- p.Pro250= Multiple submitters
- p.Ser156= Multiple submitters
Uncertain significance 41
- p.Ala149Val Single submitter ⚠
- p.Ala171Ser Single submitter ⚠
- p.Ala324Thr Single submitter ⚠
- p.Ala96Ser Single submitter ⚠
- p.Ala96Thr Single submitter ⚠
- p.Arg146Leu Single submitter ⚠
- p.Arg163Gly Single submitter ⚠
- p.Arg188Gln Single submitter ⚠
- p.Arg188Trp Single submitter ⚠
- p.Arg226Gln Single submitter ⚠
- p.Arg229Cys Single submitter ⚠
- p.Arg305Ser Single submitter ⚠
- p.Asp113Asn Single submitter ⚠
- p.Cys47Tyr Single submitter ⚠
- p.Glu221Lys Single submitter ⚠
- p.Glu53Asp Single submitter ⚠
- p.Gly155Asp Single submitter ⚠
- p.Gly158Ser Single submitter ⚠
- p.Gly176Arg Single submitter ⚠
- p.Gly180Cys Single submitter ⚠
- p.Gly79Val Single submitter ⚠
- p.His228Arg Single submitter ⚠
- p.Ile240Val Single submitter ⚠
- p.Leu15Val Single submitter ⚠
- p.Leu296Met Single submitter ⚠
- p.Leu34Val Single submitter ⚠
- p.Pro10Leu Single submitter ⚠
- p.Pro110Leu Single submitter ⚠
- p.Pro110Ser Single submitter ⚠
- p.Pro134Thr Single submitter ⚠
- p.Pro142Leu Single submitter ⚠
- p.Pro239Arg Single submitter ⚠
- p.Pro23Arg Single submitter ⚠
- p.Pro59Arg Single submitter ⚠
- p.Pro59Leu Single submitter ⚠
- p.Pro93Ser Single submitter ⚠
- p.Pro95Ala Single submitter ⚠
- p.Ser260Asn Single submitter ⚠
- p.Thr186Ile Single submitter ⚠
- p.Thr63Pro Single submitter ⚠
- p.Val199Met Single submitter ⚠