DCAF10 — 48 ClinVar variants
All ClinVar germline DCAF10 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 46 flagged for review →
2 Likely benign · 46 Uncertain significance
Full DCAF10 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 46
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 33
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- DCAF10 p.Ala114Val Uncertain significance Single submitter
- DCAF10 p.Arg130Cys Uncertain significance Single submitter
- DCAF10 p.Arg146His Uncertain significance Single submitter
- DCAF10 p.Arg223Gln Uncertain significance Single submitter
- DCAF10 p.Arg383Pro Uncertain significance Single submitter
- DCAF10 p.Arg52Gln Uncertain significance Single submitter
- DCAF10 p.Arg56Ser Uncertain significance Single submitter
- DCAF10 p.Asp139Glu Uncertain significance Single submitter
- DCAF10 p.Gln503His Uncertain significance Single submitter
- DCAF10 p.Glu26Lys Uncertain significance Single submitter
- DCAF10 p.Glu477Ala Uncertain significance Single submitter
- DCAF10 p.Gly125Arg Uncertain significance Single submitter
- DCAF10 p.Gly27Ala Uncertain significance Single submitter
- DCAF10 p.Gly27Arg Uncertain significance Single submitter
- DCAF10 p.Gly27Glu Uncertain significance Single submitter
- DCAF10 p.Gly337Arg Uncertain significance Single submitter
- DCAF10 p.Gly41Arg Uncertain significance Single submitter
- DCAF10 p.Gly69Arg Uncertain significance Single submitter
- DCAF10 p.Gly86Glu Uncertain significance Single submitter
- DCAF10 p.Gly99Arg Uncertain significance Single submitter
- DCAF10 p.Ile198Val Uncertain significance Single submitter
- DCAF10 p.Ile234Val Uncertain significance Single submitter
- DCAF10 p.Leu163Phe Uncertain significance Single submitter
- DCAF10 p.Met381Ile Uncertain significance Single submitter
- DCAF10 p.Pro119Ser Uncertain significance Single submitter
- DCAF10 p.Pro22Leu Uncertain significance Single submitter
- DCAF10 p.Pro40Ala Uncertain significance Single submitter
- DCAF10 p.Pro57Arg Uncertain significance Single submitter
- DCAF10 p.Pro6Leu Uncertain significance Single submitter
- DCAF10 p.Pro77Ser Uncertain significance Single submitter
- DCAF10 p.Pro9Leu Uncertain significance Single submitter
- DCAF10 p.Thr425Ile Uncertain significance Single submitter
- DCAF10 p.Val364Ile Uncertain significance Single submitter
Predictors split 13
The independent predictors disagree with each other — read with care.
- DCAF10 p.Ala44Val Uncertain significance Single submitter
- DCAF10 p.Arg522Cys Uncertain significance Single submitter
- DCAF10 p.Arg67Cys Uncertain significance Single submitter
- DCAF10 p.Cys429Tyr Uncertain significance Single submitter
- DCAF10 p.Glu506Asp Uncertain significance Single submitter
- DCAF10 p.Gly86Val Uncertain significance Single submitter
- DCAF10 p.His292Arg Uncertain significance Single submitter
- DCAF10 p.Ile198Thr Uncertain significance Single submitter
- DCAF10 p.Phe296Leu Uncertain significance Single submitter
- DCAF10 p.Pro157His Uncertain significance Single submitter
- DCAF10 p.Pro64Leu Uncertain significance Single submitter
- DCAF10 p.Pro90Arg Uncertain significance Single submitter
- DCAF10 p.Ser358Arg Uncertain significance Single submitter
All DCAF10 variants
Likely benign 2
- p.Gly33Arg Single submitter
- p.Ser433Thr Single submitter
Uncertain significance 46
- p.Ala114Val Single submitter ⚠
- p.Ala44Val Single submitter ⚠
- p.Arg130Cys Single submitter ⚠
- p.Arg146His Single submitter ⚠
- p.Arg223Gln Single submitter ⚠
- p.Arg383Pro Single submitter ⚠
- p.Arg522Cys Single submitter ⚠
- p.Arg52Gln Single submitter ⚠
- p.Arg56Ser Single submitter ⚠
- p.Arg67Cys Single submitter ⚠
- p.Asp139Glu Single submitter ⚠
- p.Cys429Tyr Single submitter ⚠
- p.Gln503His Single submitter ⚠
- p.Glu26Lys Single submitter ⚠
- p.Glu477Ala Single submitter ⚠
- p.Glu506Asp Single submitter ⚠
- p.Gly125Arg Single submitter ⚠
- p.Gly27Ala Single submitter ⚠
- p.Gly27Arg Single submitter ⚠
- p.Gly27Glu Single submitter ⚠
- p.Gly337Arg Single submitter ⚠
- p.Gly41Arg Single submitter ⚠
- p.Gly69Arg Single submitter ⚠
- p.Gly86Glu Single submitter ⚠
- p.Gly86Val Single submitter ⚠
- p.Gly99Arg Single submitter ⚠
- p.His292Arg Single submitter ⚠
- p.Ile198Thr Single submitter ⚠
- p.Ile198Val Single submitter ⚠
- p.Ile234Val Single submitter ⚠
- p.Leu163Phe Single submitter ⚠
- p.Met381Ile Single submitter ⚠
- p.Phe296Leu Single submitter ⚠
- p.Pro119Ser Single submitter ⚠
- p.Pro157His Single submitter ⚠
- p.Pro22Leu Single submitter ⚠
- p.Pro40Ala Single submitter ⚠
- p.Pro57Arg Single submitter ⚠
- p.Pro64Leu Single submitter ⚠
- p.Pro6Leu Single submitter ⚠
- p.Pro77Ser Single submitter ⚠
- p.Pro90Arg Single submitter ⚠
- p.Pro9Leu Single submitter ⚠
- p.Ser358Arg Single submitter ⚠
- p.Thr425Ile Single submitter ⚠
- p.Val364Ile Single submitter ⚠