DCAF11 — 74 ClinVar variants
All ClinVar germline DCAF11 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 71 flagged for review →
1 Benign · 1 Likely benign · 72 Uncertain significance
Full DCAF11 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 71
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 57
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- DCAF11 p.Ala225Gly Uncertain significance Single submitter
- DCAF11 p.Ala225Val Uncertain significance Single submitter
- DCAF11 p.Ala63Gly Uncertain significance Single submitter
- DCAF11 p.Arg102Trp Uncertain significance Single submitter
- DCAF11 p.Arg124Gln Uncertain significance Single submitter
- DCAF11 p.Arg124Leu Uncertain significance Single submitter
- DCAF11 p.Arg140Gln Uncertain significance Single submitter
- DCAF11 p.Arg140Trp Uncertain significance Single submitter
- DCAF11 p.Arg155Gln Uncertain significance Single submitter
- DCAF11 p.Arg202Gln Uncertain significance Single submitter
- DCAF11 p.Arg205Cys Uncertain significance Single submitter
- DCAF11 p.Arg22Gly Uncertain significance Single submitter
- DCAF11 p.Arg264His Uncertain significance Single submitter
- DCAF11 p.Arg265His Uncertain significance Single submitter
- DCAF11 p.Arg294Gln Uncertain significance Single submitter
- DCAF11 p.Arg298Gln Uncertain significance Single submitter
- DCAF11 p.Arg368Trp Uncertain significance Single submitter
- DCAF11 p.Arg408Trp Uncertain significance Single submitter
- DCAF11 p.Asn107Ser Uncertain significance Single submitter
- DCAF11 p.Asn481Ser Uncertain significance Single submitter
- DCAF11 p.Asp262His Uncertain significance Single submitter
- DCAF11 p.Asp37Asn Uncertain significance Single submitter
- DCAF11 p.Asp469Asn Uncertain significance Single submitter
- DCAF11 p.Gln173Glu Uncertain significance Single submitter
- DCAF11 p.Gln296Arg Uncertain significance Single submitter
- DCAF11 p.Glu307Lys Uncertain significance Single submitter
- DCAF11 p.Gly141Val Uncertain significance Single submitter
- DCAF11 p.Gly204Asp Uncertain significance Single submitter
- DCAF11 p.Gly204Ser Uncertain significance Single submitter
- DCAF11 p.His144Arg Uncertain significance Single submitter
- DCAF11 p.His482Gln Uncertain significance Single submitter
- DCAF11 p.Ile318Thr Uncertain significance Single submitter
- DCAF11 p.Ile358Leu Uncertain significance Single submitter
- DCAF11 p.Ile379Val Uncertain significance Single submitter
- DCAF11 p.Ile475Val Uncertain significance Single submitter
- DCAF11 p.Leu115Val Uncertain significance Single submitter
- DCAF11 p.Leu165Val Uncertain significance Single submitter
- DCAF11 p.Leu471Val Uncertain significance Single submitter
- DCAF11 p.Lys128Met Uncertain significance Single submitter
- DCAF11 p.Lys414Arg Uncertain significance Single submitter
- DCAF11 p.Met188Val Uncertain significance Single submitter
- DCAF11 p.Pro132Leu Uncertain significance Single submitter
- DCAF11 p.Pro16Leu Uncertain significance Single submitter
- DCAF11 p.Pro536His Uncertain significance Single submitter
- DCAF11 p.Ser270Pro Uncertain significance Single submitter
- DCAF11 p.Ser389Asn Uncertain significance Single submitter
- DCAF11 p.Ser426Asn Uncertain significance Single submitter
- DCAF11 p.Ser500Asn Uncertain significance Single submitter
- DCAF11 p.Ser500Gly Uncertain significance Single submitter
- DCAF11 p.Ser543Cys Uncertain significance Single submitter
- DCAF11 p.Thr540Ala Uncertain significance Single submitter
- DCAF11 p.Thr540Ile Uncertain significance Single submitter
- DCAF11 p.Thr540Ser Uncertain significance Single submitter
- DCAF11 p.Tyr203Phe Uncertain significance Single submitter
- DCAF11 p.Val217Ile Uncertain significance Single submitter
- DCAF11 p.Val348Met Uncertain significance Single submitter
- DCAF11 p.Val476Met Uncertain significance Single submitter
Predictors split 14
The independent predictors disagree with each other — read with care.
- DCAF11 p.Ala416Gly Uncertain significance Single submitter
- DCAF11 p.Ala43Val Uncertain significance Single submitter
- DCAF11 p.Arg264Cys Uncertain significance Single submitter
- DCAF11 p.Arg278Gln Uncertain significance Single submitter
- DCAF11 p.Asp216Asn Uncertain significance Single submitter
- DCAF11 p.Gly19Cys Uncertain significance Single submitter
- DCAF11 p.Lys110Asn Uncertain significance Single submitter
- DCAF11 p.Lys333Arg Uncertain significance Single submitter
- DCAF11 p.Lys415Asn Uncertain significance Single submitter
- DCAF11 p.Met188Thr Uncertain significance Single submitter
- DCAF11 p.Phe209Cys Uncertain significance Single submitter
- DCAF11 p.Ser320Cys Uncertain significance Single submitter
- DCAF11 p.Val412Ala Uncertain significance Single submitter
- DCAF11 p.Val489Ile Uncertain significance Single submitter
All DCAF11 variants
Benign 1
- p.Ala126Thr Multiple submitters
Likely benign 1
- p.Arg145Gln Single submitter
Uncertain significance 72
- p.Ala225Gly Single submitter ⚠
- p.Ala225Val Single submitter ⚠
- p.Ala416Gly Single submitter ⚠
- p.Ala43Val Single submitter ⚠
- p.Ala63Gly Single submitter ⚠
- p.Arg102Trp Single submitter ⚠
- p.Arg124Gln Single submitter ⚠
- p.Arg124Leu Single submitter ⚠
- p.Arg140Gln Single submitter ⚠
- p.Arg140Trp Single submitter ⚠
- p.Arg155Gln Single submitter ⚠
- p.Arg202Gln Single submitter ⚠
- p.Arg205Cys Single submitter ⚠
- p.Arg22Gly Single submitter ⚠
- p.Arg264Cys Single submitter ⚠
- p.Arg264His Single submitter ⚠
- p.Arg265His Single submitter ⚠
- p.Arg278Gln Single submitter ⚠
- p.Arg294Gln Single submitter ⚠
- p.Arg298Gln Single submitter ⚠
- p.Arg368Gln Single submitter
- p.Arg368Trp Single submitter ⚠
- p.Arg408Trp Single submitter ⚠
- p.Asn107Ser Single submitter ⚠
- p.Asn481Ser Single submitter ⚠
- p.Asp216Asn Single submitter ⚠
- p.Asp262His Single submitter ⚠
- p.Asp37Asn Single submitter ⚠
- p.Asp469Asn Single submitter ⚠
- p.Gln173Glu Single submitter ⚠
- p.Gln296Arg Single submitter ⚠
- p.Glu307Lys Single submitter ⚠
- p.Gly141Val Single submitter ⚠
- p.Gly19Cys Single submitter ⚠
- p.Gly204Asp Single submitter ⚠
- p.Gly204Ser Single submitter ⚠
- p.His144Arg Single submitter ⚠
- p.His482Gln Single submitter ⚠
- p.Ile318Thr Single submitter ⚠
- p.Ile358Leu Single submitter ⚠
- p.Ile379Val Single submitter ⚠
- p.Ile475Val Single submitter ⚠
- p.Leu115Val Single submitter ⚠
- p.Leu165Val Single submitter ⚠
- p.Leu471Val Single submitter ⚠
- p.Lys110Asn Single submitter ⚠
- p.Lys128Met Single submitter ⚠
- p.Lys333Arg Single submitter ⚠
- p.Lys414Arg Single submitter ⚠
- p.Lys415Asn Single submitter ⚠
- p.Met188Thr Single submitter ⚠
- p.Met188Val Single submitter ⚠
- p.Phe209Cys Single submitter ⚠
- p.Pro132Leu Single submitter ⚠
- p.Pro16Leu Single submitter ⚠
- p.Pro536His Single submitter ⚠
- p.Ser270Pro Single submitter ⚠
- p.Ser320Cys Single submitter ⚠
- p.Ser389Asn Single submitter ⚠
- p.Ser426Asn Single submitter ⚠
- p.Ser500Asn Single submitter ⚠
- p.Ser500Gly Single submitter ⚠
- p.Ser543Cys Single submitter ⚠
- p.Thr540Ala Single submitter ⚠
- p.Thr540Ile Single submitter ⚠
- p.Thr540Ser Single submitter ⚠
- p.Tyr203Phe Single submitter ⚠
- p.Val217Ile Single submitter ⚠
- p.Val348Met Single submitter ⚠
- p.Val412Ala Single submitter ⚠
- p.Val476Met Single submitter ⚠
- p.Val489Ile Single submitter ⚠