DCAF12 — 61 ClinVar variants
All ClinVar germline DCAF12 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 56 flagged for review →
1 Likely benign · 60 Uncertain significance
Full DCAF12 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 56
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 52
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- DCAF12 p.Ala18Gly Uncertain significance Single submitter
- DCAF12 p.Ala222Gly Uncertain significance Single submitter
- DCAF12 p.Ala233Glu Uncertain significance Single submitter
- DCAF12 p.Ala239Thr Uncertain significance Single submitter
- DCAF12 p.Arg228Trp Uncertain significance Single submitter
- DCAF12 p.Arg297His Uncertain significance Single submitter
- DCAF12 p.Arg368Gly Uncertain significance Single submitter
- DCAF12 p.Arg376Ser Uncertain significance Single submitter
- DCAF12 p.Arg65Gly Uncertain significance Single submitter
- DCAF12 p.Asn225Ser Uncertain significance Single submitter
- DCAF12 p.Asp160Asn Uncertain significance Single submitter
- DCAF12 p.Asp160Glu Uncertain significance Single submitter
- DCAF12 p.Asp181Asn Uncertain significance Single submitter
- DCAF12 p.Asp181Glu Uncertain significance Single submitter
- DCAF12 p.Asp185Asn Uncertain significance Single submitter
- DCAF12 p.Asp214Asn Uncertain significance Single submitter
- DCAF12 p.Asp427Tyr Uncertain significance Single submitter
- DCAF12 p.Gln26Glu Uncertain significance Single submitter
- DCAF12 p.Gln370Arg Uncertain significance Single submitter
- DCAF12 p.Glu350Gln Uncertain significance Single submitter
- DCAF12 p.Gly24Ser Uncertain significance Single submitter
- DCAF12 p.His100Tyr Uncertain significance Single submitter
- DCAF12 p.Ile367Phe Uncertain significance Single submitter
- DCAF12 p.Ile414Ser Uncertain significance Single submitter
- DCAF12 p.Ile414Thr Uncertain significance Single submitter
- DCAF12 p.Leu148Arg Uncertain significance Single submitter
- DCAF12 p.Leu258Val Uncertain significance Single submitter
- DCAF12 p.Leu289Phe Uncertain significance Single submitter
- DCAF12 p.Leu39Val Uncertain significance Single submitter
- DCAF12 p.Leu67Phe Uncertain significance Single submitter
- DCAF12 p.Lys184Arg Uncertain significance Single submitter
- DCAF12 p.Lys219Glu Uncertain significance Single submitter
- DCAF12 p.Lys254Arg Uncertain significance Single submitter
- DCAF12 p.Lys263Arg Uncertain significance Single submitter
- DCAF12 p.Lys51Gln Uncertain significance Single submitter
- DCAF12 p.Met207Val Uncertain significance Single submitter
- DCAF12 p.Pro13Leu Uncertain significance Single submitter
- DCAF12 p.Ser286Phe Uncertain significance Single submitter
- DCAF12 p.Ser333Thr Uncertain significance Single submitter
- DCAF12 p.Ser428Leu Uncertain significance Single submitter
- DCAF12 p.Ser64Phe Uncertain significance Single submitter
- DCAF12 p.Thr153Ile Uncertain significance Single submitter
- DCAF12 p.Thr236Ile Uncertain significance Single submitter
- DCAF12 p.Thr284Arg Uncertain significance Single submitter
- DCAF12 p.Thr291Ala Uncertain significance Single submitter
- DCAF12 p.Thr406Ala Uncertain significance Single submitter
- DCAF12 p.Thr88Asn Uncertain significance Single submitter
- DCAF12 p.Tyr168Cys Uncertain significance Single submitter
- DCAF12 p.Val115Ile Uncertain significance Single submitter
- DCAF12 p.Val255Ile Uncertain significance Single submitter
- DCAF12 p.Val42Leu Uncertain significance Single submitter
- DCAF12 p.Val66Ala Uncertain significance Single submitter
Predictors split 4
The independent predictors disagree with each other — read with care.
All DCAF12 variants
Likely benign 1
- p.Tyr275= Single submitter
Uncertain significance 60
- p.Ala18Gly Single submitter ⚠
- p.Ala222Gly Single submitter ⚠
- p.Ala233Glu Single submitter ⚠
- p.Ala239Thr Single submitter ⚠
- p.Ala449Val Single submitter ⚠
- p.Arg228Trp Single submitter ⚠
- p.Arg297His Single submitter ⚠
- p.Arg368Gly Single submitter ⚠
- p.Arg376Ser Single submitter ⚠
- p.Arg3Gln Single submitter ⚠
- p.Arg65Gly Single submitter ⚠
- p.Asn225Ser Single submitter ⚠
- p.Asp160Asn Single submitter ⚠
- p.Asp160Glu Single submitter ⚠
- p.Asp181Asn Single submitter ⚠
- p.Asp181Glu Single submitter ⚠
- p.Asp185Asn Single submitter ⚠
- p.Asp195Asn Single submitter
- p.Asp214Asn Single submitter ⚠
- p.Asp427Tyr Single submitter ⚠
- p.Gln26Glu Single submitter ⚠
- p.Gln370Arg Single submitter ⚠
- p.Gln96Arg Single submitter
- p.Glu350Gln Single submitter ⚠
- p.Gly24Ser Single submitter ⚠
- p.Gly69Arg Single submitter
- p.His100Tyr Single submitter ⚠
- p.His318Tyr Single submitter ⚠
- p.Ile367Phe Single submitter ⚠
- p.Ile414Ser Single submitter ⚠
- p.Ile414Thr Single submitter ⚠
- p.Leu148Arg Single submitter ⚠
- p.Leu258Val Single submitter ⚠
- p.Leu289Phe Single submitter ⚠
- p.Leu39Val Single submitter ⚠
- p.Leu67Phe Single submitter ⚠
- p.Lys184Arg Single submitter ⚠
- p.Lys219Glu Single submitter ⚠
- p.Lys254Arg Single submitter ⚠
- p.Lys263Arg Single submitter ⚠
- p.Lys51Gln Single submitter ⚠
- p.Met207Val Single submitter ⚠
- p.Phe416Leu Single submitter ⚠
- p.Pro13Leu Single submitter ⚠
- p.Ser286Phe Single submitter ⚠
- p.Ser333Thr Single submitter ⚠
- p.Ser428Leu Single submitter ⚠
- p.Ser64Phe Single submitter ⚠
- p.Thr153Ile Single submitter ⚠
- p.Thr172Met Single submitter
- p.Thr236Ile Single submitter ⚠
- p.Thr284Arg Single submitter ⚠
- p.Thr291Ala Single submitter ⚠
- p.Thr406Ala Single submitter ⚠
- p.Thr88Asn Single submitter ⚠
- p.Tyr168Cys Single submitter ⚠
- p.Val115Ile Single submitter ⚠
- p.Val255Ile Single submitter ⚠
- p.Val42Leu Single submitter ⚠
- p.Val66Ala Single submitter ⚠