DCAF4 — 103 ClinVar variants

All ClinVar germline DCAF4 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 76 flagged for review →

2 Benign · 16 Likely benign · 85 Uncertain significance

Full DCAF4 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 76

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors lean, ClinVar uncertain 63

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

Predictors split 13

The independent predictors disagree with each other — read with care.

All DCAF4 variants

Benign 2

p.Ser28= Multiple submitters
p.Arg447His Single submitter

Likely benign 16

p.Ser325Gly Multiple submitters
p.Arg107Gln Single submitter
p.Arg115Gln Single submitter
p.Arg162Gln Single submitter
p.Arg26His Single submitter
p.Arg377Gln Single submitter
p.Arg97Gln Single submitter
p.Asn266Ser Single submitter
p.Gly44= Single submitter
p.Gly44Ser Single submitter
p.Gly486Arg Single submitter
p.Pro51= Single submitter
p.Ser32= Single submitter
p.Ser43= Single submitter
p.Ser54= Single submitter
p.Val405Ile Single submitter

Uncertain significance 85

p.Ala125Val Single submitter ⚠
p.Ala168Gly Single submitter ⚠
p.Ala179Thr Single submitter ⚠
p.Ala233Val Single submitter ⚠
p.Ala285Ser Single submitter ⚠
p.Ala461Thr Single submitter ⚠
p.Ala478Thr Single submitter ⚠
p.Ala478Val Single submitter ⚠
p.Ala484Val Single submitter ⚠
p.Ala58Pro Single submitter ⚠
p.Arg107Trp Single submitter ⚠
p.Arg11Gln Single submitter ⚠
p.Arg120Ser Single submitter
p.Arg150Cys Single submitter ⚠
p.Arg185Gln Single submitter ⚠
p.Arg225Gln Single submitter ⚠
p.Arg26Cys Single submitter ⚠
p.Arg306Gln Single submitter ⚠
p.Arg318Gln Single submitter ⚠
p.Arg344Pro Single submitter ⚠
p.Arg354Cys Single submitter
p.Arg354His Single submitter
p.Arg366His Single submitter ⚠
p.Arg377Trp Single submitter ⚠
p.Arg471Pro Single submitter ⚠
p.Arg80Cys Single submitter ⚠
p.Arg80His Single submitter ⚠
p.Asn138Ser Single submitter ⚠
p.Asn190Thr Single submitter ⚠
p.Asn266Asp Single submitter ⚠
p.Asn266His Single submitter ⚠
p.Asn312Asp Single submitter ⚠
p.Asn89Ser Single submitter ⚠
p.Asp165Asn Single submitter ⚠
p.Asp184Asn Single submitter ⚠
p.Asp42Asn Single submitter ⚠
p.Asp435Asn Single submitter ⚠
p.Asp445Asn Single submitter ⚠
p.Cys288Gly Single submitter ⚠
p.Gln407Pro Single submitter
p.Gln7His Single submitter ⚠
p.Glu100Lys Single submitter ⚠
p.Glu111Gly Single submitter ⚠
p.Glu112Lys Single submitter ⚠
p.Glu409Lys Single submitter ⚠
p.Glu94Asp Single submitter ⚠
p.Gly284Ser Single submitter ⚠
p.Gly322Arg Single submitter ⚠
p.Gly427Glu Single submitter ⚠
p.Gly477Arg Single submitter ⚠
p.His12Asp Single submitter ⚠
p.His369Asn Single submitter
p.His421Tyr Single submitter ⚠
p.Ile351Thr Single submitter ⚠
p.Ile428Phe Single submitter ⚠
p.Leu149Arg Single submitter
p.Leu149Val Single submitter ⚠
p.Leu249Phe Single submitter ⚠
p.Leu292Gln Single submitter ⚠
p.Lys76Thr Single submitter ⚠
p.Pro253Leu Single submitter ⚠
p.Pro455Leu Single submitter
p.Pro464Ser Single submitter ⚠
p.Ser152Thr Single submitter ⚠
p.Ser229Leu Single submitter ⚠
p.Ser291Cys Single submitter ⚠
p.Ser34Phe Single submitter ⚠
p.Ser469Leu Single submitter ⚠
p.Ser493Phe Single submitter ⚠
p.Ser54Ala Single submitter ⚠
p.Ser55Phe Single submitter ⚠
p.Thr257Ser Single submitter ⚠
p.Thr302Ala Single submitter ⚠
p.Thr315Ser Single submitter ⚠
p.Thr438Met Single submitter
p.Thr53Ile Single submitter ⚠
p.Trp6Arg Single submitter ⚠
p.Tyr417Phe Single submitter ⚠
p.Val192Ala Single submitter ⚠
p.Val227Ala Single submitter ⚠
p.Val230Ala Single submitter ⚠
p.Val308Ile Single submitter ⚠
p.Val308Phe Single submitter ⚠
p.Val412Met Single submitter ⚠
c.728+1334G>A No assertion criteria Telomere length, mean leukocyte