DCAF7 — 11 ClinVar variants
All ClinVar germline DCAF7 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 7 flagged for review →
3 Benign · 8 Uncertain significance
Full DCAF7 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 7
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 5
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
Predictors split 2
The independent predictors disagree with each other — read with care.
All DCAF7 variants
Uncertain significance 8
- p.Asp53Gly Single submitter ⚠
- p.Glu58Gly Single submitter
- p.Gly186Trp Single submitter ⚠
- p.Met299Val Single submitter ⚠
- p.Phe65Val Single submitter ⚠
- p.Pro16Ser Single submitter ⚠
- p.Val201Met Single submitter ⚠
- p.Val83Ile Single submitter ⚠