DCD — 19 ClinVar variants
All ClinVar germline DCD variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 18 flagged for review →
1 Benign · 2 Likely benign · 16 Uncertain significance
Full DCD gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 18
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 9
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- DCD p.Asn32Lys Uncertain significance Single submitter
- DCD p.Asn32Ser Uncertain significance Single submitter
- DCD p.Asp101Glu Uncertain significance Single submitter
- DCD p.Glu89Lys Uncertain significance Single submitter
- DCD p.Glu92Gly Uncertain significance Single submitter
- DCD p.Gly46Val Uncertain significance Single submitter
- DCD p.Leu6Val Uncertain significance Single submitter
- DCD p.Ser30Leu Uncertain significance Single submitter
- DCD p.Ser93Asn Uncertain significance Single submitter
Predictors split 9
The independent predictors disagree with each other — read with care.
- DCD p.Asp71Asn Benign Multiple submitters
- DCD p.Gly81Arg Uncertain significance Single submitter
- DCD p.Leu65Phe Uncertain significance Single submitter
- DCD p.Leu66Pro Uncertain significance Single submitter
- DCD p.Pro28Arg Uncertain significance Single submitter
- DCD p.Val105Phe Uncertain significance Single submitter
- DCD p.Val109Ala Uncertain significance Single submitter
- DCD p.Val94Met Uncertain significance Single submitter
- DCD p.Val99Ile Likely benign Single submitter
All DCD variants
Benign 1
- p.Asp71Asn Multiple submitters ⚠
Likely benign 2
- p.Ala24= Single submitter
- p.Val99Ile Single submitter ⚠
Uncertain significance 16
- p.Asn32Lys Single submitter ⚠
- p.Asn32Ser Single submitter ⚠
- p.Asp101Glu Single submitter ⚠
- p.Glu89Lys Single submitter ⚠
- p.Glu92Gly Single submitter ⚠
- p.Gly46Val Single submitter ⚠
- p.Gly81Arg Single submitter ⚠
- p.Leu65Phe Single submitter ⚠
- p.Leu66Pro Single submitter ⚠
- p.Leu6Val Single submitter ⚠
- p.Pro28Arg Single submitter ⚠
- p.Ser30Leu Single submitter ⚠
- p.Ser93Asn Single submitter ⚠
- p.Val105Phe Single submitter ⚠
- p.Val109Ala Single submitter ⚠
- p.Val94Met Single submitter ⚠