DCP1A — 64 ClinVar variants
All ClinVar germline DCP1A variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 60 flagged for review →
1 Benign · 2 Likely benign · 61 Uncertain significance
Full DCP1A gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 60
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 56
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- DCP1A p.Ala210Val Uncertain significance Single submitter
- DCP1A p.Ala268Thr Uncertain significance Single submitter
- DCP1A p.Ala344Ser Uncertain significance Single submitter
- DCP1A p.Ala3Val Uncertain significance Single submitter
- DCP1A p.Ala443Thr Uncertain significance Single submitter
- DCP1A p.Ala444Gly Uncertain significance Single submitter
- DCP1A p.Ala458Thr Uncertain significance Single submitter
- DCP1A p.Arg117Leu Uncertain significance Single submitter
- DCP1A p.Arg131Gln Uncertain significance Single submitter
- DCP1A p.Arg132Gln Uncertain significance Single submitter
- DCP1A p.Asn576Lys Uncertain significance Single submitter
- DCP1A p.Asp139Asn Uncertain significance Single submitter
- DCP1A p.Gln264Arg Uncertain significance Single submitter
- DCP1A p.Gln330Lys Uncertain significance Single submitter
- DCP1A p.Gln9Lys Uncertain significance Single submitter
- DCP1A p.Glu196Asp Uncertain significance Single submitter
- DCP1A p.Glu196Lys Uncertain significance Single submitter
- DCP1A p.Glu51Val Uncertain significance Single submitter
- DCP1A p.Gly204Arg Uncertain significance Single submitter
- DCP1A p.Gly213Glu Uncertain significance Single submitter
- DCP1A p.Gly386Ala Uncertain significance Single submitter
- DCP1A p.Gly413Ala Uncertain significance Single submitter
- DCP1A p.Gly415Arg Uncertain significance Single submitter
- DCP1A p.Gly426Asp Uncertain significance Single submitter
- DCP1A p.His306Tyr Uncertain significance Single submitter
- DCP1A p.His365Tyr Uncertain significance Single submitter
- DCP1A p.His404Arg Uncertain significance Single submitter
- DCP1A p.His76Arg Uncertain significance Single submitter
- DCP1A p.Ile288Met Uncertain significance Single submitter
- DCP1A p.Leu265Ile Uncertain significance Single submitter
- DCP1A p.Leu355Phe Uncertain significance Single submitter
- DCP1A p.Leu452Val Uncertain significance Single submitter
- DCP1A p.Leu457Phe Uncertain significance Single submitter
- DCP1A p.Lys140Arg Uncertain significance Single submitter
- DCP1A p.Met463Leu Uncertain significance Single submitter
- DCP1A p.Met463Val Uncertain significance Single submitter
- DCP1A p.Pro286Arg Uncertain significance Single submitter
- DCP1A p.Pro333Ala Uncertain significance Single submitter
- DCP1A p.Pro423Gln Uncertain significance Single submitter
- DCP1A p.Pro459Ser Uncertain significance Single submitter
- DCP1A p.Ser180Ile Uncertain significance Single submitter
- DCP1A p.Ser203Phe Uncertain significance Single submitter
- DCP1A p.Ser339Gly Uncertain significance Single submitter
- DCP1A p.Ser439Cys Uncertain significance Single submitter
- DCP1A p.Ser449Leu Uncertain significance Single submitter
- DCP1A p.Ser453Gly Uncertain significance Single submitter
- DCP1A p.Ser514Tyr Uncertain significance Single submitter
- DCP1A p.Ser525Pro Uncertain significance Single submitter
- DCP1A p.Thr311Ile Uncertain significance Single submitter
- DCP1A p.Thr328Ala Uncertain significance Single submitter
- DCP1A p.Thr347Ser Uncertain significance Single submitter
- DCP1A p.Thr401Ala Uncertain significance Single submitter
- DCP1A p.Tyr97Cys Uncertain significance Single submitter
- DCP1A p.Val292Met Uncertain significance Single submitter
- DCP1A p.Val331Asp Uncertain significance Single submitter
- DCP1A p.Val392Ala Uncertain significance Single submitter
Predictors split 4
The independent predictors disagree with each other — read with care.
All DCP1A variants
Benign 1
- p.Ala447Val Multiple submitters
Likely benign 2
- p.Asn255Ser Single submitter
- p.Asn303Ser Single submitter
Uncertain significance 61
- p.Ala210Val Single submitter ⚠
- p.Ala268Thr Single submitter ⚠
- p.Ala344Ser Single submitter ⚠
- p.Ala3Val Single submitter ⚠
- p.Ala443Thr Single submitter ⚠
- p.Ala444Gly Single submitter ⚠
- p.Ala458Thr Single submitter ⚠
- p.Ala7Gly Single submitter
- p.Arg117Leu Single submitter ⚠
- p.Arg131Gln Single submitter ⚠
- p.Arg132Gln Single submitter ⚠
- p.Asn576Lys Single submitter ⚠
- p.Asp139Asn Single submitter ⚠
- p.Gln264Arg Single submitter ⚠
- p.Gln330Lys Single submitter ⚠
- p.Gln9Lys Single submitter ⚠
- p.Glu196Asp Single submitter ⚠
- p.Glu196Lys Single submitter ⚠
- p.Glu51Val Single submitter ⚠
- p.Gly204Arg Single submitter ⚠
- p.Gly213Glu Single submitter ⚠
- p.Gly386Ala Single submitter ⚠
- p.Gly413Ala Single submitter ⚠
- p.Gly415Arg Single submitter ⚠
- p.Gly426Asp Single submitter ⚠
- p.His306Tyr Single submitter ⚠
- p.His365Tyr Single submitter ⚠
- p.His404Arg Single submitter ⚠
- p.His76Arg Single submitter ⚠
- p.Ile288Met Single submitter ⚠
- p.Leu265Ile Single submitter ⚠
- p.Leu355Phe Single submitter ⚠
- p.Leu395Pro Single submitter ⚠
- p.Leu452Val Single submitter ⚠
- p.Leu457Phe Single submitter ⚠
- p.Lys140Arg Single submitter ⚠
- p.Met463Leu Single submitter ⚠
- p.Met463Val Single submitter ⚠
- p.Pro286Arg Single submitter ⚠
- p.Pro333Ala Single submitter ⚠
- p.Pro423Gln Single submitter ⚠
- p.Pro459Ser Single submitter ⚠
- p.Ser180Ile Single submitter ⚠
- p.Ser203Phe Single submitter ⚠
- p.Ser339Gly Single submitter ⚠
- p.Ser439Cys Single submitter ⚠
- p.Ser449Leu Single submitter ⚠
- p.Ser453Gly Single submitter ⚠
- p.Ser514Tyr Single submitter ⚠
- p.Ser525Pro Single submitter ⚠
- p.Ser62Tyr Single submitter ⚠
- p.Thr311Ile Single submitter ⚠
- p.Thr328Ala Single submitter ⚠
- p.Thr347Ser Single submitter ⚠
- p.Thr401Ala Single submitter ⚠
- p.Tyr22Cys Single submitter ⚠
- p.Tyr97Cys Single submitter ⚠
- p.Val125Ala Single submitter ⚠
- p.Val292Met Single submitter ⚠
- p.Val331Asp Single submitter ⚠
- p.Val392Ala Single submitter ⚠