DCP2 — 56 ClinVar variants
All ClinVar germline DCP2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 54 flagged for review →
1 Likely benign · 55 Uncertain significance
Full DCP2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 54
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 40
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- DCP2 p.Ala390Glu Uncertain significance Single submitter
- DCP2 p.Arg166Gln Uncertain significance Single submitter
- DCP2 p.Arg173Cys Uncertain significance Single submitter
- DCP2 p.Arg241Gln Uncertain significance Single submitter
- DCP2 p.Arg274His Uncertain significance Single submitter
- DCP2 p.Asn187Asp Uncertain significance Single submitter
- DCP2 p.Asn302Lys Uncertain significance Single submitter
- DCP2 p.Asn321Ser Uncertain significance Single submitter
- DCP2 p.Asn346Ser Uncertain significance Single submitter
- DCP2 p.Asp250Glu Uncertain significance Single submitter
- DCP2 p.Asp362Val Uncertain significance Single submitter
- DCP2 p.Asp410Gly Uncertain significance Single submitter
- DCP2 p.Cys351Tyr Uncertain significance Single submitter
- DCP2 p.Gln316Glu Uncertain significance Single submitter
- DCP2 p.Gln361Glu Uncertain significance Single submitter
- DCP2 p.Gln52Lys Uncertain significance Single submitter
- DCP2 p.Glu377Lys Uncertain significance Single submitter
- DCP2 p.Gly283Ser Uncertain significance Single submitter
- DCP2 p.Gly286Asp Uncertain significance Single submitter
- DCP2 p.Gly322Ser Uncertain significance Single submitter
- DCP2 p.Gly80Asp Uncertain significance Single submitter
- DCP2 p.His275Gln Uncertain significance Single submitter
- DCP2 p.His411Arg Uncertain significance Single submitter
- DCP2 p.His411Pro Uncertain significance Single submitter
- DCP2 p.Ile202Val Uncertain significance Single submitter
- DCP2 p.Ile33Val Uncertain significance Single submitter
- DCP2 p.Leu339Phe Uncertain significance Single submitter
- DCP2 p.Leu381Pro Uncertain significance Single submitter
- DCP2 p.Lys224Arg Uncertain significance Single submitter
- DCP2 p.Lys272Arg Uncertain significance Single submitter
- DCP2 p.Lys343Gln Uncertain significance Single submitter
- DCP2 p.Met318Ile Uncertain significance Single submitter
- DCP2 p.Met95Ile Uncertain significance Single submitter
- DCP2 p.Pro74Leu Uncertain significance Single submitter
- DCP2 p.Ser11Thr Uncertain significance Single submitter
- DCP2 p.Ser317Thr Uncertain significance Single submitter
- DCP2 p.Thr264Ala Uncertain significance Single submitter
- DCP2 p.Val145Ala Uncertain significance Single submitter
- DCP2 p.Val290Leu Uncertain significance Single submitter
- DCP2 p.Val6Met Uncertain significance Single submitter
Predictors split 14
The independent predictors disagree with each other — read with care.
- DCP2 p.Arg274Cys Uncertain significance Single submitter
- DCP2 p.Asn168Asp Uncertain significance Single submitter
- DCP2 p.Asn53Tyr Uncertain significance Single submitter
- DCP2 p.Asp82Val Uncertain significance Single submitter
- DCP2 p.Asp88His Uncertain significance Single submitter
- DCP2 p.Gln79Pro Uncertain significance Single submitter
- DCP2 p.Glu107Asp Uncertain significance Single submitter
- DCP2 p.Glu84Lys Uncertain significance Single submitter
- DCP2 p.Pro234Leu Uncertain significance Single submitter
- DCP2 p.Pro9Ser Uncertain significance Single submitter
- DCP2 p.Thr259Met Uncertain significance Single submitter
- DCP2 p.Tyr50Cys Uncertain significance Single submitter
- DCP2 p.Val389Met Uncertain significance Single submitter
- DCP2 p.Val69Ala Uncertain significance Single submitter
All DCP2 variants
Likely benign 1
- p.Met318Val Single submitter
Uncertain significance 55
- p.Ala390Glu Single submitter ⚠
- p.Arg166Gln Single submitter ⚠
- p.Arg173Cys Single submitter ⚠
- p.Arg241Gln Single submitter ⚠
- p.Arg274Cys Single submitter ⚠
- p.Arg274His Single submitter ⚠
- p.Asn168Asp Single submitter ⚠
- p.Asn187Asp Single submitter ⚠
- p.Asn302Lys Single submitter ⚠
- p.Asn321Ser Single submitter ⚠
- p.Asn346Ser Single submitter ⚠
- p.Asn53Tyr Single submitter ⚠
- p.Asp250Glu Single submitter ⚠
- p.Asp30fs Single submitter
- p.Asp362Val Single submitter ⚠
- p.Asp410Gly Single submitter ⚠
- p.Asp82Val Single submitter ⚠
- p.Asp88His Single submitter ⚠
- p.Cys351Tyr Single submitter ⚠
- p.Gln316Glu Single submitter ⚠
- p.Gln361Glu Single submitter ⚠
- p.Gln52Lys Single submitter ⚠
- p.Gln79Pro Single submitter ⚠
- p.Glu107Asp Single submitter ⚠
- p.Glu377Lys Single submitter ⚠
- p.Glu84Lys Single submitter ⚠
- p.Gly283Ser Single submitter ⚠
- p.Gly286Asp Single submitter ⚠
- p.Gly322Ser Single submitter ⚠
- p.Gly80Asp Single submitter ⚠
- p.His275Gln Single submitter ⚠
- p.His411Arg Single submitter ⚠
- p.His411Pro Single submitter ⚠
- p.Ile202Val Single submitter ⚠
- p.Ile33Val Single submitter ⚠
- p.Leu339Phe Single submitter ⚠
- p.Leu381Pro Single submitter ⚠
- p.Lys224Arg Single submitter ⚠
- p.Lys272Arg Single submitter ⚠
- p.Lys343Gln Single submitter ⚠
- p.Met318Ile Single submitter ⚠
- p.Met95Ile Single submitter ⚠
- p.Pro234Leu Single submitter ⚠
- p.Pro74Leu Single submitter ⚠
- p.Pro9Ser Single submitter ⚠
- p.Ser11Thr Single submitter ⚠
- p.Ser317Thr Single submitter ⚠
- p.Thr259Met Single submitter ⚠
- p.Thr264Ala Single submitter ⚠
- p.Tyr50Cys Single submitter ⚠
- p.Val145Ala Single submitter ⚠
- p.Val290Leu Single submitter ⚠
- p.Val389Met Single submitter ⚠
- p.Val69Ala Single submitter ⚠
- p.Val6Met Single submitter ⚠