DCTN3 — 26 ClinVar variants
All ClinVar germline DCTN3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 24 flagged for review →
26 Uncertain significance
Full DCTN3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 24
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 18
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- DCTN3 p.Ala178Thr Uncertain significance Single submitter
- DCTN3 p.Arg13Gln Uncertain significance Single submitter
- DCTN3 p.Arg19Leu Uncertain significance Single submitter
- DCTN3 p.Asp35Glu Uncertain significance Single submitter
- DCTN3 p.Asp6Asn Uncertain significance Single submitter
- DCTN3 p.Asp74Asn Uncertain significance Single submitter
- DCTN3 p.Gln41Arg Uncertain significance Single submitter
- DCTN3 p.Gln8Arg Uncertain significance Single submitter
- DCTN3 p.Glu16Lys Uncertain significance Single submitter
- DCTN3 p.Gly23Arg Uncertain significance Single submitter
- DCTN3 p.Leu172Phe Uncertain significance Single submitter
- DCTN3 p.Leu37Val Uncertain significance Single submitter
- DCTN3 p.Lys148Arg Uncertain significance Single submitter
- DCTN3 p.Phe93Val Uncertain significance Single submitter
- DCTN3 p.Ser162Thr Uncertain significance Single submitter
- DCTN3 p.Val14Met Uncertain significance Single submitter
- DCTN3 p.Val38Ile Uncertain significance Single submitter
- DCTN3 p.Val98Ala Uncertain significance Single submitter
Predictors split 6
The independent predictors disagree with each other — read with care.
- DCTN3 p.Arg125Cys Uncertain significance Single submitter
- DCTN3 p.Arg13Leu Uncertain significance Single submitter
- DCTN3 p.Arg75Cys Uncertain significance Single submitter
- DCTN3 p.Arg75Leu Uncertain significance Single submitter
- DCTN3 p.Lys66Asn Uncertain significance Single submitter
- DCTN3 p.Thr144Pro Uncertain significance Single submitter
All DCTN3 variants
Uncertain significance 26
- p.Ala178Thr Single submitter ⚠
- p.Arg125Cys Single submitter ⚠
- p.Arg13Gln Single submitter ⚠
- p.Arg13Leu Single submitter ⚠
- p.Arg19Leu Single submitter ⚠
- p.Arg75Cys Single submitter ⚠
- p.Arg75Leu Single submitter ⚠
- p.Asp35Glu Single submitter ⚠
- p.Asp6Asn Single submitter ⚠
- p.Asp74Asn Single submitter ⚠
- p.Gln41Arg Single submitter ⚠
- p.Gln8Arg Single submitter ⚠
- p.Glu16Lys Single submitter ⚠
- p.Glu91Asp Single submitter
- p.Gly23Arg Single submitter ⚠
- p.Leu172Phe Single submitter ⚠
- p.Leu37Val Single submitter ⚠
- p.Lys148Arg Single submitter ⚠
- p.Lys66Asn Single submitter ⚠
- p.Phe93Val Single submitter ⚠
- p.Ser162Thr Single submitter ⚠
- p.Thr144Pro Single submitter ⚠
- p.Val14Met Single submitter ⚠
- p.Val166Ala Single submitter
- p.Val38Ile Single submitter ⚠
- p.Val98Ala Single submitter ⚠