DCTN4 — 61 ClinVar variants
All ClinVar germline DCTN4 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 55 flagged for review →
3 Benign · 1 Likely benign · 57 Uncertain significance
Full DCTN4 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 55
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 40
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- DCTN4 p.Ala195Thr Uncertain significance Single submitter
- DCTN4 p.Ala221Thr Uncertain significance Single submitter
- DCTN4 p.Ala22Val Uncertain significance Single submitter
- DCTN4 p.Ala2Ser Uncertain significance Single submitter
- DCTN4 p.Arg162Gln Uncertain significance Single submitter
- DCTN4 p.Arg169Gln Uncertain significance Single submitter
- DCTN4 p.Arg192Gln Uncertain significance Single submitter
- DCTN4 p.Arg273Trp Uncertain significance Single submitter
- DCTN4 p.Arg278Cys Uncertain significance Single submitter
- DCTN4 p.Arg278His Uncertain significance Single submitter
- DCTN4 p.Arg433Cys Uncertain significance Single submitter
- DCTN4 p.Arg433His Uncertain significance Single submitter
- DCTN4 p.Asn72Ser Uncertain significance Single submitter
- DCTN4 p.Asp120Val Uncertain significance Single submitter
- DCTN4 p.Asp388Asn Uncertain significance Single submitter
- DCTN4 p.Asp424His Uncertain significance Single submitter
- DCTN4 p.Asp96Gly Uncertain significance Single submitter
- DCTN4 p.Gln152Arg Uncertain significance Single submitter
- DCTN4 p.Gln383His Uncertain significance Single submitter
- DCTN4 p.Gln6Leu Uncertain significance Single submitter
- DCTN4 p.Gly132Ser Uncertain significance Single submitter
- DCTN4 p.Gly441Arg Uncertain significance Single submitter
- DCTN4 p.Ile432Val Uncertain significance Single submitter
- DCTN4 p.Ile435Thr Uncertain significance Single submitter
- DCTN4 p.Leu167Gln Uncertain significance Single submitter
- DCTN4 p.Lys166Arg Uncertain significance Single submitter
- DCTN4 p.Lys363Arg Uncertain significance Single submitter
- DCTN4 p.Lys64Arg Uncertain significance Single submitter
- DCTN4 p.Met144Leu Uncertain significance Single submitter
- DCTN4 p.Met80Thr Uncertain significance Single submitter
- DCTN4 p.Pro431Leu Uncertain significance Single submitter
- DCTN4 p.Ser354Asn Uncertain significance Single submitter
- DCTN4 p.Ser38Trp Uncertain significance Single submitter
- DCTN4 p.Ser91Ala Uncertain significance Single submitter
- DCTN4 p.Thr102Ile Uncertain significance Single submitter
- DCTN4 p.Tyr107Cys Uncertain significance Single submitter
- DCTN4 p.Val325Gly Uncertain significance Single submitter
- DCTN4 p.Val333Ile Uncertain significance Single submitter
- DCTN4 p.Val406Leu Uncertain significance Single submitter
- DCTN4 p.Val444Ile Uncertain significance Single submitter
Predictors split 15
The independent predictors disagree with each other — read with care.
- DCTN4 p.Arg143Trp Uncertain significance Single submitter
- DCTN4 p.Arg21Gly Uncertain significance Single submitter
- DCTN4 p.Arg9Leu Uncertain significance Single submitter
- DCTN4 p.Asn427Lys Uncertain significance Single submitter
- DCTN4 p.Gly122Ser Uncertain significance Single submitter
- DCTN4 p.Gly202Arg Uncertain significance Single submitter
- DCTN4 p.Gly413Asp Uncertain significance Single submitter
- DCTN4 p.Lys405Glu Uncertain significance Single submitter
- DCTN4 p.Pro236Leu Uncertain significance Single submitter
- DCTN4 p.Pro236Ser Uncertain significance Single submitter
- DCTN4 p.Thr330Lys Uncertain significance Single submitter
- DCTN4 p.Thr355Ile Uncertain significance Single submitter
- DCTN4 p.Thr85Ser Uncertain significance Single submitter
- DCTN4 p.Tyr32Cys Uncertain significance Single submitter
- DCTN4 p.Val415Met Uncertain significance Single submitter
All DCTN4 variants
Likely benign 1
- p.Val366Ile Single submitter
Uncertain significance 57
- p.Ala195Thr Single submitter ⚠
- p.Ala221Thr Single submitter ⚠
- p.Ala22Val Single submitter ⚠
- p.Ala2Ser Single submitter ⚠
- p.Arg143Trp Single submitter ⚠
- p.Arg162Gln Single submitter ⚠
- p.Arg169Gln Single submitter ⚠
- p.Arg192Gln Single submitter ⚠
- p.Arg21Gly Single submitter ⚠
- p.Arg273Gln Single submitter
- p.Arg273Trp Single submitter ⚠
- p.Arg278Cys Single submitter ⚠
- p.Arg278His Single submitter ⚠
- p.Arg433Cys Single submitter ⚠
- p.Arg433His Single submitter ⚠
- p.Arg9Leu Single submitter ⚠
- p.Asn427Lys Single submitter ⚠
- p.Asn72Ser Single submitter ⚠
- p.Asp120Val Single submitter ⚠
- p.Asp388Asn Single submitter ⚠
- p.Asp424His Single submitter ⚠
- p.Asp96Gly Single submitter ⚠
- p.Gln152Arg Single submitter ⚠
- p.Gln383His Single submitter ⚠
- p.Gln6Leu Single submitter ⚠
- p.Gly122Ser Single submitter ⚠
- p.Gly132Ser Single submitter ⚠
- p.Gly202Arg Single submitter ⚠
- p.Gly413Asp Single submitter ⚠
- p.Gly441Arg Single submitter ⚠
- p.Ile432Val Single submitter ⚠
- p.Ile435Thr Single submitter ⚠
- p.Leu167Gln Single submitter ⚠
- p.Leu83Val Single submitter
- p.Lys166Arg Single submitter ⚠
- p.Lys363Arg Single submitter ⚠
- p.Lys405Glu Single submitter ⚠
- p.Lys64Arg Single submitter ⚠
- p.Met144Leu Single submitter ⚠
- p.Met80Thr Single submitter ⚠
- p.Pro236Leu Single submitter ⚠
- p.Pro236Ser Single submitter ⚠
- p.Pro431Leu Single submitter ⚠
- p.Ser354Asn Single submitter ⚠
- p.Ser38Trp Single submitter ⚠
- p.Ser91Ala Single submitter ⚠
- p.Thr102Ile Single submitter ⚠
- p.Thr330Lys Single submitter ⚠
- p.Thr355Ile Single submitter ⚠
- p.Thr85Ser Single submitter ⚠
- p.Tyr107Cys Single submitter ⚠
- p.Tyr32Cys Single submitter ⚠
- p.Val325Gly Single submitter ⚠
- p.Val333Ile Single submitter ⚠
- p.Val406Leu Single submitter ⚠
- p.Val415Met Single submitter ⚠
- p.Val444Ile Single submitter ⚠