DCTN5 — 20 ClinVar variants
All ClinVar germline DCTN5 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 19 flagged for review →
20 Uncertain significance
Full DCTN5 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 19
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 15
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- DCTN5 p.Arg118Cys Uncertain significance Single submitter
- DCTN5 p.Arg119Gln Uncertain significance Single submitter
- DCTN5 p.Asn100Ser Uncertain significance Single submitter
- DCTN5 p.Cys126Trp Uncertain significance Single submitter
- DCTN5 p.Cys46Arg Uncertain significance Single submitter
- DCTN5 p.Cys97Phe Uncertain significance Single submitter
- DCTN5 p.Glu12Asp Uncertain significance Single submitter
- DCTN5 p.Gly105Val Uncertain significance Single submitter
- DCTN5 p.Leu6Val Uncertain significance Single submitter
- DCTN5 p.Met43Ile Uncertain significance Single submitter
- DCTN5 p.Ser106Pro Uncertain significance Single submitter
- DCTN5 p.Ser171Asn Uncertain significance Single submitter
- DCTN5 p.Ser26Leu Uncertain significance Single submitter
- DCTN5 p.Val133Leu Uncertain significance Single submitter
- DCTN5 p.Val99Ile Uncertain significance Single submitter
Predictors split 4
The independent predictors disagree with each other — read with care.
All DCTN5 variants
Uncertain significance 20
- p.Arg118Cys Single submitter ⚠
- p.Arg119Gln Single submitter ⚠
- p.Asn100Ser Single submitter ⚠
- p.Cys126Trp Single submitter ⚠
- p.Cys46Arg Single submitter ⚠
- p.Cys97Phe Single submitter ⚠
- p.Glu12Asp Single submitter ⚠
- p.Glu15Gln Single submitter ⚠
- p.Gly105Val Single submitter ⚠
- p.His86Arg Single submitter ⚠
- p.Leu6Val Single submitter ⚠
- p.Met43Ile Single submitter ⚠
- p.Pro141Ala Single submitter ⚠
- p.Ser106Pro Single submitter ⚠
- p.Ser171Asn Single submitter ⚠
- p.Ser26Leu Single submitter ⚠
- p.Thr40Ala Single submitter
- p.Tyr107Cys Single submitter ⚠
- p.Val133Leu Single submitter ⚠
- p.Val99Ile Single submitter ⚠