DCTPP1 — 33 ClinVar variants
All ClinVar germline DCTPP1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 27 flagged for review →
3 Likely benign · 30 Uncertain significance
Full DCTPP1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 27
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 17
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- DCTPP1 p.Ala18Pro Uncertain significance Single submitter
- DCTPP1 p.Arg109Cys Uncertain significance Single submitter
- DCTPP1 p.Arg111Cys Uncertain significance Single submitter
- DCTPP1 p.Arg35Cys Uncertain significance Single submitter
- DCTPP1 p.Arg89Gln Uncertain significance Single submitter
- DCTPP1 p.Arg9Leu Uncertain significance Single submitter
- DCTPP1 p.Arg9Ser Uncertain significance Single submitter
- DCTPP1 p.Glu15Ala Uncertain significance Single submitter
- DCTPP1 p.Gly80Ser Uncertain significance Single submitter
- DCTPP1 p.Ile8Phe Uncertain significance Single submitter
- DCTPP1 p.Leu96Phe Uncertain significance Single submitter
- DCTPP1 p.Pro115Ala Uncertain significance Single submitter
- DCTPP1 p.Pro115Leu Uncertain significance Single submitter
- DCTPP1 p.Pro86Thr Uncertain significance Single submitter
- DCTPP1 p.Tyr102Cys Uncertain significance Single submitter
- DCTPP1 p.Val155Met Uncertain significance Single submitter
- DCTPP1 p.Val99Ile Uncertain significance Single submitter
Predictors split 10
The independent predictors disagree with each other — read with care.
- DCTPP1 p.Arg126Trp Uncertain significance Single submitter
- DCTPP1 p.Arg135Cys Uncertain significance Single submitter
- DCTPP1 p.Arg135His Uncertain significance Single submitter
- DCTPP1 p.Arg22Trp Uncertain significance Single submitter
- DCTPP1 p.Asp76Asn Uncertain significance Single submitter
- DCTPP1 p.Gly13Trp Uncertain significance Single submitter
- DCTPP1 p.Met122Thr Uncertain significance Single submitter
- DCTPP1 p.Pro115Arg Uncertain significance Single submitter
- DCTPP1 p.Ser2Phe Uncertain significance Single submitter
- DCTPP1 p.Val104Met Uncertain significance Single submitter
All DCTPP1 variants
Likely benign 3
- p.Arg111His Single submitter
- p.Arg127Gln Single submitter
- p.Ile34= Single submitter
Uncertain significance 30
- p.Ala18Pro Single submitter ⚠
- p.Arg109Cys Single submitter ⚠
- p.Arg111Cys Single submitter ⚠
- p.Arg126Trp Single submitter ⚠
- p.Arg135Cys Single submitter ⚠
- p.Arg135His Single submitter ⚠
- p.Arg22Trp Single submitter ⚠
- p.Arg35Cys Single submitter ⚠
- p.Arg89Gln Single submitter ⚠
- p.Arg9Leu Single submitter ⚠
- p.Arg9Ser Single submitter ⚠
- p.Asp76Asn Single submitter ⚠
- p.Glu15Ala Single submitter ⚠
- p.Gly13Trp Single submitter ⚠
- p.Gly80Ser Single submitter ⚠
- p.Ile8Phe Single submitter ⚠
- p.Leu96Phe Single submitter ⚠
- p.Met122Thr Single submitter ⚠
- p.Pro115Ala Single submitter ⚠
- p.Pro115Arg Single submitter ⚠
- p.Pro115Leu Single submitter ⚠
- p.Pro86Thr Single submitter ⚠
- p.Ser137Phe Single submitter
- p.Ser2Phe Single submitter ⚠
- p.Tyr102Cys Single submitter ⚠
- p.Tyr141Phe Single submitter
- p.Val104Ala Single submitter
- p.Val104Met Single submitter ⚠
- p.Val155Met Single submitter ⚠
- p.Val99Ile Single submitter ⚠