DCUN1D4 — 24 ClinVar variants
All ClinVar germline DCUN1D4 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 23 flagged for review →
1 Likely benign · 23 Uncertain significance
Full DCUN1D4 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 23
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 16
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- DCUN1D4 p.Ala114Gly Uncertain significance Single submitter
- DCUN1D4 p.Asn152Ser Uncertain significance Single submitter
- DCUN1D4 p.Asp42Asn Uncertain significance Single submitter
- DCUN1D4 p.Gln11His Uncertain significance Single submitter
- DCUN1D4 p.Glu281Lys Uncertain significance Single submitter
- DCUN1D4 p.Gly39Val Uncertain significance Single submitter
- DCUN1D4 p.Ile94Val Uncertain significance Single submitter
- DCUN1D4 p.Leu158Val Uncertain significance Single submitter
- DCUN1D4 p.Lys31Glu Uncertain significance Single submitter
- DCUN1D4 p.Met220Ile Uncertain significance Single submitter
- DCUN1D4 p.Phe193Leu Uncertain significance Single submitter
- DCUN1D4 p.Ser259Gly Uncertain significance Single submitter
- DCUN1D4 p.Thr191Ala Uncertain significance Single submitter
- DCUN1D4 p.Trp229Cys Uncertain significance Single submitter
- DCUN1D4 p.Tyr286Ser Uncertain significance Single submitter
- DCUN1D4 p.Val246Ala Uncertain significance Single submitter
Predictors split 7
The independent predictors disagree with each other — read with care.
- DCUN1D4 p.Asn254Ser Uncertain significance Single submitter
- DCUN1D4 p.Ile132Met Uncertain significance Single submitter
- DCUN1D4 p.Leu16Pro Uncertain significance Single submitter
- DCUN1D4 p.Lys147Gln Uncertain significance Single submitter
- DCUN1D4 p.Lys245Arg Uncertain significance Single submitter
- DCUN1D4 p.Lys95Asn Uncertain significance Single submitter
- DCUN1D4 p.Thr191Pro Uncertain significance Single submitter
All DCUN1D4 variants
Likely benign 1
- p.Ile38Val Single submitter
Uncertain significance 23
- p.Ala114Gly Single submitter ⚠
- p.Asn152Ser Single submitter ⚠
- p.Asn254Ser Single submitter ⚠
- p.Asp42Asn Single submitter ⚠
- p.Gln11His Single submitter ⚠
- p.Glu281Lys Single submitter ⚠
- p.Gly39Val Single submitter ⚠
- p.Ile132Met Single submitter ⚠
- p.Ile94Val Single submitter ⚠
- p.Leu158Val Single submitter ⚠
- p.Leu16Pro Single submitter ⚠
- p.Lys147Gln Single submitter ⚠
- p.Lys245Arg Single submitter ⚠
- p.Lys31Glu Single submitter ⚠
- p.Lys95Asn Single submitter ⚠
- p.Met220Ile Single submitter ⚠
- p.Phe193Leu Single submitter ⚠
- p.Ser259Gly Single submitter ⚠
- p.Thr191Ala Single submitter ⚠
- p.Thr191Pro Single submitter ⚠
- p.Trp229Cys Single submitter ⚠
- p.Tyr286Ser Single submitter ⚠
- p.Val246Ala Single submitter ⚠