DDA1 — 13 ClinVar variants
All ClinVar germline DDA1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 13 flagged for review →
13 Uncertain significance
Full DDA1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 13
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 6
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- DDA1 p.Ala21Val Uncertain significance Single submitter
- DDA1 p.Arg31Trp Uncertain significance Single submitter
- DDA1 p.Asn67Tyr Uncertain significance Single submitter
- DDA1 p.Glu100Lys Uncertain significance Single submitter
- DDA1 p.Glu82Asp Uncertain significance Single submitter
- DDA1 p.His99Gln Uncertain significance Single submitter
Predictors split 7
The independent predictors disagree with each other — read with care.
- DDA1 p.Ala91Val Uncertain significance Single submitter
- DDA1 p.Arg31Gln Uncertain significance Single submitter
- DDA1 p.Asp101Tyr Uncertain significance Single submitter
- DDA1 p.Asp22Asn Uncertain significance Single submitter
- DDA1 p.Ser23Pro Uncertain significance Single submitter
- DDA1 p.Ser95Gly Uncertain significance Single submitter
- DDA1 p.Val24Met Uncertain significance Single submitter
All DDA1 variants
Uncertain significance 13
- p.Ala21Val Single submitter ⚠
- p.Ala91Val Single submitter ⚠
- p.Arg31Gln Single submitter ⚠
- p.Arg31Trp Single submitter ⚠
- p.Asn67Tyr Single submitter ⚠
- p.Asp101Tyr Single submitter ⚠
- p.Asp22Asn Single submitter ⚠
- p.Glu100Lys Single submitter ⚠
- p.Glu82Asp Single submitter ⚠
- p.His99Gln Single submitter ⚠
- p.Ser23Pro Single submitter ⚠
- p.Ser95Gly Single submitter ⚠
- p.Val24Met Single submitter ⚠