DDIT4L — 28 ClinVar variants
All ClinVar germline DDIT4L variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 27 flagged for review →
28 Uncertain significance
Full DDIT4L gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 27
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 21
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- DDIT4L p.Ala13Thr Uncertain significance Single submitter
- DDIT4L p.Ala89Thr Uncertain significance Single submitter
- DDIT4L p.Arg104Gly Uncertain significance Single submitter
- DDIT4L p.Arg159Pro Uncertain significance Single submitter
- DDIT4L p.Asn116Asp Uncertain significance Single submitter
- DDIT4L p.Gln70Leu Uncertain significance Single submitter
- DDIT4L p.Glu46Gly Uncertain significance Single submitter
- DDIT4L p.Glu46Lys Uncertain significance Single submitter
- DDIT4L p.Gly105Val Uncertain significance Single submitter
- DDIT4L p.Gly186Arg Uncertain significance Single submitter
- DDIT4L p.His109Gln Uncertain significance Single submitter
- DDIT4L p.Ile124Thr Uncertain significance Single submitter
- DDIT4L p.Ile185Thr Uncertain significance Single submitter
- DDIT4L p.Phe155Leu Uncertain significance Single submitter
- DDIT4L p.Pro25Ser Uncertain significance Single submitter
- DDIT4L p.Ser171Gly Uncertain significance Single submitter
- DDIT4L p.Thr133Ala Uncertain significance Single submitter
- DDIT4L p.Thr188Ile Uncertain significance Single submitter
- DDIT4L p.Thr98Arg Uncertain significance Single submitter
- DDIT4L p.Thr98Met Uncertain significance Single submitter
- DDIT4L p.Val47Leu Uncertain significance Single submitter
Predictors split 6
The independent predictors disagree with each other — read with care.
- DDIT4L p.Asp122Val Uncertain significance Single submitter
- DDIT4L p.Gln142Leu Uncertain significance Single submitter
- DDIT4L p.Glu62Asp Uncertain significance Single submitter
- DDIT4L p.Ile124Phe Uncertain significance Single submitter
- DDIT4L p.Val131Ala Uncertain significance Single submitter
- DDIT4L p.Val177Ala Uncertain significance Single submitter
All DDIT4L variants
Uncertain significance 28
- p.Ala13Thr Single submitter ⚠
- p.Ala89Thr Single submitter ⚠
- p.Arg104Gly Single submitter ⚠
- p.Arg159Pro Single submitter ⚠
- p.Asn116Asp Single submitter ⚠
- p.Asp122Val Single submitter ⚠
- p.Cys118Arg Single submitter
- p.Gln142Leu Single submitter ⚠
- p.Gln70Leu Single submitter ⚠
- p.Glu46Gly Single submitter ⚠
- p.Glu46Lys Single submitter ⚠
- p.Glu62Asp Single submitter ⚠
- p.Gly105Val Single submitter ⚠
- p.Gly186Arg Single submitter ⚠
- p.His109Gln Single submitter ⚠
- p.Ile124Phe Single submitter ⚠
- p.Ile124Thr Single submitter ⚠
- p.Ile185Thr Single submitter ⚠
- p.Phe155Leu Single submitter ⚠
- p.Pro25Ser Single submitter ⚠
- p.Ser171Gly Single submitter ⚠
- p.Thr133Ala Single submitter ⚠
- p.Thr188Ile Single submitter ⚠
- p.Thr98Arg Single submitter ⚠
- p.Thr98Met Single submitter ⚠
- p.Val131Ala Single submitter ⚠
- p.Val177Ala Single submitter ⚠
- p.Val47Leu Single submitter ⚠