DDN — 100 ClinVar variants
All ClinVar germline DDN variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 93 flagged for review →
2 Benign · 5 Likely benign · 93 Uncertain significance
Full DDN gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 93
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 65
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- DDN p.Ala154Thr Uncertain significance Single submitter
- DDN p.Ala169Val Uncertain significance Single submitter
- DDN p.Ala174Glu Uncertain significance Single submitter
- DDN p.Ala179Thr Uncertain significance Single submitter
- DDN p.Ala305Thr Uncertain significance Single submitter
- DDN p.Ala341Thr Uncertain significance Single submitter
- DDN p.Ala553Asp Uncertain significance Single submitter
- DDN p.Ala553Gly Uncertain significance Single submitter
- DDN p.Ala572Val Uncertain significance Single submitter
- DDN p.Arg176Gly Uncertain significance Single submitter
- DDN p.Arg434Leu Uncertain significance Single submitter
- DDN p.Arg441Leu Uncertain significance Single submitter
- DDN p.Arg484Gly Uncertain significance Single submitter
- DDN p.Arg484Pro Uncertain significance Single submitter
- DDN p.Arg535Gly Uncertain significance Single submitter
- DDN p.Arg544Gly Uncertain significance Single submitter
- DDN p.Arg583Gly Uncertain significance Single submitter
- DDN p.Arg598Gln Uncertain significance Single submitter
- DDN p.Arg598Leu Uncertain significance Single submitter
- DDN p.Arg598Pro Uncertain significance Single submitter
- DDN p.Arg69Ser Uncertain significance Single submitter
- DDN p.Asn326Ser Uncertain significance Single submitter
- DDN p.Asp488Asn Uncertain significance Single submitter
- DDN p.Glu20Gln Uncertain significance Single submitter
- DDN p.Glu20Lys Uncertain significance Single submitter
- DDN p.Glu414Asp Uncertain significance Single submitter
- DDN p.Glu420Lys Uncertain significance Single submitter
- DDN p.Glu428Lys Uncertain significance Single submitter
- DDN p.Glu498Lys Uncertain significance Single submitter
- DDN p.Glu632Asp Uncertain significance Single submitter
- DDN p.Glu656Asp Uncertain significance Single submitter
- DDN p.Glu661Asp Uncertain significance Single submitter
- DDN p.Gly214Glu Uncertain significance Single submitter
- DDN p.Gly247Arg Uncertain significance Single submitter
- DDN p.Gly286Ser Uncertain significance Single submitter
- DDN p.Gly290Val Uncertain significance Single submitter
- DDN p.Gly487Glu Uncertain significance Single submitter
- DDN p.Gly663Arg Uncertain significance Single submitter
- DDN p.His397Arg Uncertain significance Single submitter
- DDN p.Lys270Arg Uncertain significance Single submitter
- DDN p.Lys271Gln Uncertain significance Single submitter
- DDN p.Lys384Thr Uncertain significance Single submitter
- DDN p.Met55Leu Uncertain significance Single submitter
- DDN p.Pro160Leu Uncertain significance Single submitter
- DDN p.Pro165Arg Uncertain significance Single submitter
- DDN p.Pro185Leu Uncertain significance Single submitter
- DDN p.Pro275Ser Uncertain significance Single submitter
- DDN p.Pro358Ala Uncertain significance Single submitter
- DDN p.Pro394Leu Uncertain significance Single submitter
- DDN p.Pro536Leu Uncertain significance Single submitter
- DDN p.Pro552Ser Uncertain significance Single submitter
- DDN p.Pro81Ser Uncertain significance Single submitter
- DDN p.Pro82Leu Uncertain significance Single submitter
- DDN p.Ser13Gly Uncertain significance Single submitter
- DDN p.Ser371Leu Uncertain significance Single submitter
- DDN p.Ser688Arg Uncertain significance Single submitter
- DDN p.Thr215Pro Uncertain significance Single submitter
- DDN p.Thr253Ser Uncertain significance Single submitter
- DDN p.Thr269Pro Uncertain significance Single submitter
- DDN p.Thr352Pro Uncertain significance Single submitter
- DDN p.Thr469Asn Uncertain significance Single submitter
- DDN p.Thr469Pro Uncertain significance Single submitter
- DDN p.Trp193Arg Uncertain significance Single submitter
- DDN p.Trp430Gly Uncertain significance Single submitter
- DDN p.Val693Phe Uncertain significance Single submitter
Predictors split 28
The independent predictors disagree with each other — read with care.
- DDN p.Arg167Cys Uncertain significance Single submitter
- DDN p.Arg435His Uncertain significance Single submitter
- DDN p.Arg48Cys Uncertain significance Single submitter
- DDN p.Arg598Trp Uncertain significance Single submitter
- DDN p.Arg69Cys Uncertain significance Single submitter
- DDN p.Arg69His Uncertain significance Single submitter
- DDN p.Cys459Phe Uncertain significance Single submitter
- DDN p.Gln18His Uncertain significance Single submitter
- DDN p.Glu585Lys Uncertain significance Single submitter
- DDN p.Gly247Trp Uncertain significance Single submitter
- DDN p.Gly286Asp Uncertain significance Single submitter
- DDN p.Gly537Trp Uncertain significance Single submitter
- DDN p.Gly605Glu Uncertain significance Single submitter
- DDN p.His206Tyr Uncertain significance Single submitter
- DDN p.Leu159Ile Uncertain significance Single submitter
- DDN p.Leu273Met Uncertain significance Single submitter
- DDN p.Leu368Phe Uncertain significance Single submitter
- DDN p.Leu91Gln Uncertain significance Single submitter
- DDN p.Leu91Pro Uncertain significance Single submitter
- DDN p.Lys123Met Uncertain significance Single submitter
- DDN p.Pro226Ser Uncertain significance Single submitter
- DDN p.Ser464Tyr Uncertain significance Single submitter
- DDN p.Ser652Phe Uncertain significance Single submitter
- DDN p.Ser679Arg Uncertain significance Single submitter
- DDN p.Thr215Asn Uncertain significance Single submitter
- DDN p.Thr504Met Uncertain significance Single submitter
- DDN p.Thr563Met Uncertain significance Single submitter
- DDN p.Thr628Lys Uncertain significance Single submitter
All DDN variants
Benign 2
- p.Glu661Gly Multiple submitters
- p.Pro358Arg Multiple submitters
Likely benign 5
- p.Ala553Val Single submitter
- p.Arg559Gln Single submitter
- p.Gly681Arg Single submitter
- p.Leu156Pro Single submitter
- p.Pro246= Single submitter
Uncertain significance 93
- p.Ala154Thr Single submitter ⚠
- p.Ala169Val Single submitter ⚠
- p.Ala174Glu Single submitter ⚠
- p.Ala179Thr Single submitter ⚠
- p.Ala305Thr Single submitter ⚠
- p.Ala341Thr Single submitter ⚠
- p.Ala553Asp Single submitter ⚠
- p.Ala553Gly Single submitter ⚠
- p.Ala572Val Single submitter ⚠
- p.Arg167Cys Single submitter ⚠
- p.Arg176Gly Single submitter ⚠
- p.Arg434Leu Single submitter ⚠
- p.Arg435His Single submitter ⚠
- p.Arg441Leu Single submitter ⚠
- p.Arg484Gly Single submitter ⚠
- p.Arg484Pro Single submitter ⚠
- p.Arg48Cys Single submitter ⚠
- p.Arg535Gly Single submitter ⚠
- p.Arg544Gly Single submitter ⚠
- p.Arg583Gly Single submitter ⚠
- p.Arg598Gln Single submitter ⚠
- p.Arg598Leu Single submitter ⚠
- p.Arg598Pro Single submitter ⚠
- p.Arg598Trp Single submitter ⚠
- p.Arg69Cys Single submitter ⚠
- p.Arg69His Single submitter ⚠
- p.Arg69Ser Single submitter ⚠
- p.Asn326Ser Single submitter ⚠
- p.Asp488Asn Single submitter ⚠
- p.Cys459Phe Single submitter ⚠
- p.Gln18His Single submitter ⚠
- p.Glu20Gln Single submitter ⚠
- p.Glu20Lys Single submitter ⚠
- p.Glu414Asp Single submitter ⚠
- p.Glu420Lys Single submitter ⚠
- p.Glu428Lys Single submitter ⚠
- p.Glu498Lys Single submitter ⚠
- p.Glu585Lys Single submitter ⚠
- p.Glu632Asp Single submitter ⚠
- p.Glu656Asp Single submitter ⚠
- p.Glu661Asp Single submitter ⚠
- p.Gly214Glu Single submitter ⚠
- p.Gly247Arg Single submitter ⚠
- p.Gly247Trp Single submitter ⚠
- p.Gly286Asp Single submitter ⚠
- p.Gly286Ser Single submitter ⚠
- p.Gly290Val Single submitter ⚠
- p.Gly487Glu Single submitter ⚠
- p.Gly537Trp Single submitter ⚠
- p.Gly605Glu Single submitter ⚠
- p.Gly663Arg Single submitter ⚠
- p.His206Tyr Single submitter ⚠
- p.His397Arg Single submitter ⚠
- p.Leu159Ile Single submitter ⚠
- p.Leu273Met Single submitter ⚠
- p.Leu368Phe Single submitter ⚠
- p.Leu91Gln Single submitter ⚠
- p.Leu91Pro Single submitter ⚠
- p.Lys123Met Single submitter ⚠
- p.Lys270Arg Single submitter ⚠
- p.Lys271Gln Single submitter ⚠
- p.Lys384Thr Single submitter ⚠
- p.Met55Leu Single submitter ⚠
- p.Pro160Leu Single submitter ⚠
- p.Pro165Arg Single submitter ⚠
- p.Pro185Leu Single submitter ⚠
- p.Pro226Ser Single submitter ⚠
- p.Pro275Ser Single submitter ⚠
- p.Pro358Ala Single submitter ⚠
- p.Pro394Leu Single submitter ⚠
- p.Pro536Leu Single submitter ⚠
- p.Pro552Ser Single submitter ⚠
- p.Pro81Ser Single submitter ⚠
- p.Pro82Leu Single submitter ⚠
- p.Ser13Gly Single submitter ⚠
- p.Ser371Leu Single submitter ⚠
- p.Ser464Tyr Single submitter ⚠
- p.Ser652Phe Single submitter ⚠
- p.Ser679Arg Single submitter ⚠
- p.Ser688Arg Single submitter ⚠
- p.Thr215Asn Single submitter ⚠
- p.Thr215Pro Single submitter ⚠
- p.Thr253Ser Single submitter ⚠
- p.Thr269Pro Single submitter ⚠
- p.Thr352Pro Single submitter ⚠
- p.Thr469Asn Single submitter ⚠
- p.Thr469Pro Single submitter ⚠
- p.Thr504Met Single submitter ⚠
- p.Thr563Met Single submitter ⚠
- p.Thr628Lys Single submitter ⚠
- p.Trp193Arg Single submitter ⚠
- p.Trp430Gly Single submitter ⚠
- p.Val693Phe Single submitter ⚠