DDX25 — 102 ClinVar variants
All ClinVar germline DDX25 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 66 flagged for review →
1 Pathogenic · 28 Benign · 2 Likely benign · 71 Uncertain significance
Full DDX25 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 66
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 52
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- DDX25 p.Ala472Thr Uncertain significance Single submitter
- DDX25 p.Arg17Trp Uncertain significance Single submitter
- DDX25 p.Arg377Pro Uncertain significance Single submitter
- DDX25 p.Arg434Trp Uncertain significance Single submitter
- DDX25 p.Asn51Ser Uncertain significance Single submitter
- DDX25 p.Asp213Asn Uncertain significance Single submitter
- DDX25 p.Asp213Glu Uncertain significance Single submitter
- DDX25 p.Asp213Gly Uncertain significance Single submitter
- DDX25 p.Asp284Glu Uncertain significance Single submitter
- DDX25 p.Asp361Tyr Uncertain significance Single submitter
- DDX25 p.Asp451Asn Uncertain significance Single submitter
- DDX25 p.Asp60His Uncertain significance Single submitter
- DDX25 p.Asp9Glu Uncertain significance Single submitter
- DDX25 p.Cys172Ser Uncertain significance Single submitter
- DDX25 p.Cys319Gly Uncertain significance Single submitter
- DDX25 p.Gln266Arg Uncertain significance Single submitter
- DDX25 p.Gln266Glu Uncertain significance Single submitter
- DDX25 p.Gln327Arg Uncertain significance Single submitter
- DDX25 p.Glu320Asp Uncertain significance Single submitter
- DDX25 p.Glu320Gly Uncertain significance Single submitter
- DDX25 p.Gly257Arg Uncertain significance Single submitter
- DDX25 p.Gly334Val Uncertain significance Single submitter
- DDX25 p.Gly34Val Uncertain significance Single submitter
- DDX25 p.Gly370Arg Uncertain significance Single submitter
- DDX25 p.Gly436Glu Uncertain significance Single submitter
- DDX25 p.Gly442Ser Uncertain significance Single submitter
- DDX25 p.His21Arg Uncertain significance Single submitter
- DDX25 p.His261Pro Uncertain significance Single submitter
- DDX25 p.Ile402Phe Uncertain significance Single submitter
- DDX25 p.Ile402Thr Uncertain significance Single submitter
- DDX25 p.Ile467Val Uncertain significance Single submitter
- DDX25 p.Leu132Pro Uncertain significance Single submitter
- DDX25 p.Leu155Phe Uncertain significance Single submitter
- DDX25 p.Leu158Phe Uncertain significance Single submitter
- DDX25 p.Leu164Val Uncertain significance Single submitter
- DDX25 p.Leu18Pro Uncertain significance Single submitter
- DDX25 p.Leu4Ser Uncertain significance Single submitter
- DDX25 p.Lys149Asn Uncertain significance Single submitter
- DDX25 p.Lys216Gln Uncertain significance Single submitter
- DDX25 p.Lys440Ile Uncertain significance Single submitter
- DDX25 p.Met126Thr Uncertain significance Single submitter
- DDX25 p.Pro209Leu Uncertain significance Single submitter
- DDX25 p.Pro454Thr Uncertain significance Single submitter
- DDX25 p.Ser15Thr Uncertain significance Single submitter
- DDX25 p.Ser23Pro Uncertain significance Single submitter
- DDX25 p.Ser37Arg Uncertain significance Single submitter
- DDX25 p.Ser46Phe Uncertain significance Single submitter
- DDX25 p.Thr222Ser Uncertain significance Single submitter
- DDX25 p.Trp6Cys Uncertain significance Single submitter
- DDX25 p.Val161Ile Uncertain significance Single submitter
- DDX25 p.Val356Met Uncertain significance Single submitter
- DDX25 p.Val374Met Uncertain significance Single submitter
Predictors split 14
The independent predictors disagree with each other — read with care.
- DDX25 p.Arg303Cys Uncertain significance Single submitter
- DDX25 p.Arg303Ser Uncertain significance Single submitter
- DDX25 p.Arg313Trp Uncertain significance Single submitter
- DDX25 p.Asp424Glu Uncertain significance Single submitter
- DDX25 p.Glu188Gly Uncertain significance Single submitter
- DDX25 p.Leu354Phe Uncertain significance Single submitter
- DDX25 p.Lys122Gln Uncertain significance Single submitter
- DDX25 p.Phe193Cys Uncertain significance Single submitter
- DDX25 p.Ser159Gly Uncertain significance Single submitter
- DDX25 p.Ser91Cys Uncertain significance Single submitter
- DDX25 p.Thr212Asn Uncertain significance Single submitter
- DDX25 p.Thr225Ile Uncertain significance Single submitter
- DDX25 p.Thr98Ala Uncertain significance Single submitter
- DDX25 p.Tyr94Ser Uncertain significance Single submitter
All DDX25 variants
Pathogenic 1
- p.Arg377Ter No assertion criteria azoospermia
Benign 28
- c.1202-69C>T Multiple submitters
- c.1390+242C>T Multiple submitters
- c.1391-299T>C Multiple submitters
- c.311+155G>C Multiple submitters
- c.404+36T>C Multiple submitters
- c.507+53T>A Multiple submitters
- c.507+55G>T Multiple submitters
- c.508-65C>T Multiple submitters
- c.*280T>G Multiple submitters
- p.Ala268= Multiple submitters
- p.Asn138= Multiple submitters
- p.Cys398= Multiple submitters
- c.1038+297C>T Single submitter
- c.1038+315G>A Single submitter
- c.1038+333A>C Single submitter
- c.1039-268C>A Single submitter
- c.1201+300G>A Single submitter
- c.1202-271AC[12] Single submitter
- c.1202-271AC[15] Single submitter
- c.311+263C>T Single submitter
- c.312-141G>T Single submitter
- c.508-154A>C Single submitter
- c.508-343G>A Single submitter
- c.508-6C>T Single submitter
- c.-280+632G>C Single submitter
- c.-280+726C>T Single submitter
- c.-280+761G>T Single submitter
- c.-280+872_-280+890del Single submitter
Likely benign 2
- p.Arg267= Single submitter
- p.Arg349Gln Single submitter
Uncertain significance 71
- p.Ala472Thr Single submitter ⚠
- p.Arg17Trp Single submitter ⚠
- p.Arg303Cys Single submitter ⚠
- p.Arg303Ser Single submitter ⚠
- p.Arg313Trp Single submitter ⚠
- p.Arg348His Single submitter
- p.Arg377Pro Single submitter ⚠
- p.Arg434Trp Single submitter ⚠
- p.Asn51Ser Single submitter ⚠
- p.Asp213Asn Single submitter ⚠
- p.Asp213Glu Single submitter ⚠
- p.Asp213Gly Single submitter ⚠
- p.Asp284Glu Single submitter ⚠
- p.Asp361Tyr Single submitter ⚠
- p.Asp424Glu Single submitter ⚠
- p.Asp451Asn Single submitter ⚠
- p.Asp60His Single submitter ⚠
- p.Asp9Glu Single submitter ⚠
- p.Cys172Ser Single submitter ⚠
- p.Cys319Gly Single submitter ⚠
- p.Gln266Arg Single submitter ⚠
- p.Gln266Glu Single submitter ⚠
- p.Gln327Arg Single submitter ⚠
- p.Gln406Ter Single submitter
- p.Glu188Gly Single submitter ⚠
- p.Glu320Asp Single submitter ⚠
- p.Glu320Gly Single submitter ⚠
- p.Gly257Arg Single submitter ⚠
- p.Gly334Val Single submitter ⚠
- p.Gly34Val Single submitter ⚠
- p.Gly370Arg Single submitter ⚠
- p.Gly436Glu Single submitter ⚠
- p.Gly442Ser Single submitter ⚠
- p.His21Arg Single submitter ⚠
- p.His261Pro Single submitter ⚠
- p.Ile402Phe Single submitter ⚠
- p.Ile402Thr Single submitter ⚠
- p.Ile467Val Single submitter ⚠
- p.Leu132Pro Single submitter ⚠
- p.Leu155Phe Single submitter ⚠
- p.Leu158Phe Single submitter ⚠
- p.Leu164Val Single submitter ⚠
- p.Leu18Pro Single submitter ⚠
- p.Leu354Phe Single submitter ⚠
- p.Leu4Ser Single submitter ⚠
- p.Lys122Gln Single submitter ⚠
- p.Lys149Asn Single submitter ⚠
- p.Lys216Gln Single submitter ⚠
- p.Lys440Ile Single submitter ⚠
- p.Met126Thr Single submitter ⚠
- p.Phe193Cys Single submitter ⚠
- p.Pro168Ser Single submitter
- p.Pro209Leu Single submitter ⚠
- p.Pro454Thr Single submitter ⚠
- p.Ser159Gly Single submitter ⚠
- p.Ser15Thr Single submitter ⚠
- p.Ser23Pro Single submitter ⚠
- p.Ser37Arg Single submitter ⚠
- p.Ser46Phe Single submitter ⚠
- p.Ser91Cys Single submitter ⚠
- p.Thr212Asn Single submitter ⚠
- p.Thr222Ser Single submitter ⚠
- p.Thr225Ile Single submitter ⚠
- p.Thr98Ala Single submitter ⚠
- p.Trp6Cys Single submitter ⚠
- p.Tyr94Ser Single submitter ⚠
- p.Val161Ile Single submitter ⚠
- p.Val161Leu Single submitter
- p.Val186Gly Single submitter
- p.Val356Met Single submitter ⚠
- p.Val374Met Single submitter ⚠