DDX27 — 90 ClinVar variants
All ClinVar germline DDX27 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 51 flagged for review →
4 Benign · 5 Likely benign · 81 Uncertain significance
Full DDX27 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 51
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 43
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- DDX27 c.-33G>A Uncertain significance Single submitter
- DDX27 p.Ala147Thr Uncertain significance Single submitter
- DDX27 p.Ala256Thr Uncertain significance Single submitter
- DDX27 p.Ala308Val Uncertain significance Single submitter
- DDX27 p.Ala553Val Uncertain significance Single submitter
- DDX27 p.Arg254His Uncertain significance Single submitter
- DDX27 p.Arg365His Uncertain significance Single submitter
- DDX27 p.Arg47Cys Uncertain significance Single submitter
- DDX27 p.Arg604Trp Uncertain significance Single submitter
- DDX27 p.Arg688His Uncertain significance Single submitter
- DDX27 p.Arg694Gln Uncertain significance Single submitter
- DDX27 p.Arg751Gly Uncertain significance Single submitter
- DDX27 p.Arg8Leu Uncertain significance Single submitter
- DDX27 p.Asn130Ser Uncertain significance Single submitter
- DDX27 p.Asn723Ser Uncertain significance Single submitter
- DDX27 p.Glu103Gln Uncertain significance Single submitter
- DDX27 p.Glu117Gln Uncertain significance Single submitter
- DDX27 p.Glu129Asp Uncertain significance Single submitter
- DDX27 p.Glu132Lys Uncertain significance Single submitter
- DDX27 p.Glu546Asp Uncertain significance Single submitter
- DDX27 p.Gly17Glu Uncertain significance Single submitter
- DDX27 p.Gly17Val Uncertain significance Single submitter
- DDX27 p.Gly500Glu Uncertain significance Single submitter
- DDX27 p.Gly752Arg Uncertain significance Single submitter
- DDX27 p.Ile34Val Uncertain significance Single submitter
- DDX27 p.Leu187Phe Uncertain significance Single submitter
- DDX27 p.Leu486Val Uncertain significance Single submitter
- DDX27 p.Leu5Phe Uncertain significance Single submitter
- DDX27 p.Lys164Arg Uncertain significance Single submitter
- DDX27 p.Lys252Arg Uncertain significance Single submitter
- DDX27 p.Lys660Asn Uncertain significance Single submitter
- DDX27 p.Met74Val Uncertain significance Single submitter
- DDX27 p.Pro257Leu Uncertain significance Single submitter
- DDX27 p.Pro705Ser Uncertain significance Single submitter
- DDX27 p.Ser188Leu Uncertain significance Single submitter
- DDX27 p.Ser48Arg Uncertain significance Single submitter
- DDX27 p.Ser725Asn Uncertain significance Single submitter
- DDX27 p.Thr142Ala Uncertain significance Single submitter
- DDX27 p.Thr211Ala Uncertain significance Single submitter
- DDX27 p.Thr267Ile Uncertain significance Single submitter
- DDX27 p.Thr278Ile Uncertain significance Single submitter
- DDX27 p.Thr85Ala Uncertain significance Single submitter
- DDX27 p.Tyr144Cys Uncertain significance Single submitter
Predictors split 8
The independent predictors disagree with each other — read with care.
- DDX27 p.Arg477His Uncertain significance Single submitter
- DDX27 p.Arg528Ser Uncertain significance Single submitter
- DDX27 p.Arg682Gln Uncertain significance Single submitter
- DDX27 p.Asp156Gly Uncertain significance Single submitter
- DDX27 p.Leu721Phe Uncertain significance Single submitter
- DDX27 p.Lys756Glu Uncertain significance Single submitter
- DDX27 p.Pro561Leu Uncertain significance Single submitter
- DDX27 p.Thr722Ile Uncertain significance Single submitter
All DDX27 variants
Benign 4
- p.Ala239= Multiple submitters
- p.Glu172Lys Multiple submitters
- c.1898-140G>A Single submitter
- p.Ala155= Single submitter
Likely benign 5
- c.-32T>C Single submitter
- p.Gln190= Single submitter
- p.Gly294= Single submitter
- p.Leu7Phe Single submitter
- p.Thr63Met Single submitter
Uncertain significance 81
- c.52C>G Single submitter
- c.-33G>A Single submitter ⚠
- p.Ala147Thr Single submitter ⚠
- p.Ala256Thr Single submitter ⚠
- p.Ala308Val Single submitter ⚠
- p.Ala553Val Single submitter ⚠
- p.Ala587Val Single submitter
- p.Ala636Thr Single submitter
- p.Arg254His Single submitter ⚠
- p.Arg260Cys Single submitter
- p.Arg306Gln Single submitter
- p.Arg365His Single submitter ⚠
- p.Arg405Trp Single submitter
- p.Arg476Trp Single submitter
- p.Arg477His Single submitter ⚠
- p.Arg47Cys Single submitter ⚠
- p.Arg528Ser Single submitter ⚠
- p.Arg541Trp Single submitter
- p.Arg569Trp Single submitter
- p.Arg604Trp Single submitter ⚠
- p.Arg682Gln Single submitter ⚠
- p.Arg688His Single submitter ⚠
- p.Arg694Gln Single submitter ⚠
- p.Arg751Gly Single submitter ⚠
- p.Arg8Leu Single submitter ⚠
- p.Asn130Ser Single submitter ⚠
- p.Asn600Thr Single submitter
- p.Asn723Ser Single submitter ⚠
- p.Asp156Gly Single submitter ⚠
- p.Asp310Glu Single submitter
- p.Asp484Gly Single submitter
- p.Asp87Gly Single submitter
- p.Asp87Val Single submitter
- p.Gln743Pro Single submitter
- p.Glu103Gln Single submitter ⚠
- p.Glu117Gln Single submitter ⚠
- p.Glu129Asp Single submitter ⚠
- p.Glu132Lys Single submitter ⚠
- p.Glu420Lys Single submitter
- p.Glu546Asp Single submitter ⚠
- p.Glu618Lys Single submitter
- p.Gly17Glu Single submitter ⚠
- p.Gly17Val Single submitter ⚠
- p.Gly500Glu Single submitter ⚠
- p.Gly752Arg Single submitter ⚠
- p.Ile34Val Single submitter ⚠
- p.Leu187Phe Single submitter ⚠
- p.Leu249Val Single submitter
- p.Leu337Phe Single submitter
- p.Leu486Val Single submitter ⚠
- p.Leu5Phe Single submitter ⚠
- p.Leu674His Single submitter
- p.Leu721Phe Single submitter ⚠
- p.Lys164Arg Single submitter ⚠
- p.Lys252Arg Single submitter ⚠
- p.Lys660Asn Single submitter ⚠
- p.Lys756Glu Single submitter ⚠
- p.Met455Thr Single submitter
- p.Met74Val Single submitter ⚠
- p.Pro257Leu Single submitter ⚠
- p.Pro561Leu Single submitter ⚠
- p.Pro705Ser Single submitter ⚠
- p.Ser188Leu Single submitter ⚠
- p.Ser383Phe Single submitter
- p.Ser48Arg Single submitter ⚠
- p.Ser595Leu Single submitter
- p.Ser725Asn Single submitter ⚠
- p.Thr142Ala Single submitter ⚠
- p.Thr211Ala Single submitter ⚠
- p.Thr267Ile Single submitter ⚠
- p.Thr278Ile Single submitter ⚠
- p.Thr503Met Single submitter
- p.Thr508Lys Single submitter
- p.Thr722Ile Single submitter ⚠
- p.Thr85Ala Single submitter ⚠
- p.Tyr144Cys Single submitter ⚠
- p.Val17Glu Single submitter
- p.Val261Met Single submitter
- p.Val263Ala Single submitter
- p.Val423Met Single submitter
- p.Val487Met Single submitter