DDX28 — 74 ClinVar variants
All ClinVar germline DDX28 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 73 flagged for review →
2 Likely benign · 72 Uncertain significance
Full DDX28 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 73
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 35
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- DDX28 p.Ala102Gly Uncertain significance Single submitter
- DDX28 p.Ala172Thr Uncertain significance Single submitter
- DDX28 p.Ala216Pro Uncertain significance Single submitter
- DDX28 p.Arg426Ser Uncertain significance Single submitter
- DDX28 p.Arg436Ser Uncertain significance Single submitter
- DDX28 p.Arg86Leu Uncertain significance Single submitter
- DDX28 p.Asp293Asn Uncertain significance Single submitter
- DDX28 p.Asp30Asn Uncertain significance Single submitter
- DDX28 p.Gln155Arg Uncertain significance Single submitter
- DDX28 p.Gln279His Uncertain significance Single submitter
- DDX28 p.Gln339Leu Uncertain significance Single submitter
- DDX28 p.Glu143Lys Uncertain significance Single submitter
- DDX28 p.Glu298Gln Uncertain significance Single submitter
- DDX28 p.Gly312Arg Uncertain significance Single submitter
- DDX28 p.Gly65Ala Uncertain significance Single submitter
- DDX28 p.His106Tyr Uncertain significance Single submitter
- DDX28 p.Ile515Met Uncertain significance Single submitter
- DDX28 p.Leu215Phe Uncertain significance Single submitter
- DDX28 p.Leu33Arg Uncertain significance Single submitter
- DDX28 p.Leu42Val Uncertain significance Single submitter
- DDX28 p.Leu536Val Uncertain significance Single submitter
- DDX28 p.Leu61Val Uncertain significance Single submitter
- DDX28 p.Lys271Arg Uncertain significance Single submitter
- DDX28 p.Met435Leu Uncertain significance Single submitter
- DDX28 p.Phe474Ser Uncertain significance Single submitter
- DDX28 p.Phe502Ser Uncertain significance Single submitter
- DDX28 p.Pro74Gln Uncertain significance Single submitter
- DDX28 p.Ser123Leu Uncertain significance Single submitter
- DDX28 p.Ser99Arg Uncertain significance Single submitter
- DDX28 p.Thr179Ile Uncertain significance Single submitter
- DDX28 p.Thr179Pro Uncertain significance Single submitter
- DDX28 p.Thr262Ile Uncertain significance Single submitter
- DDX28 p.Val488Ala Uncertain significance Single submitter
- DDX28 p.Val503Leu Uncertain significance Single submitter
- DDX28 p.Val512Phe Uncertain significance Single submitter
Predictors split 38
The independent predictors disagree with each other — read with care.
- DDX28 p.Ala2Gly Uncertain significance Single submitter
- DDX28 p.Ala379Val Uncertain significance Single submitter
- DDX28 p.Arg166Cys Uncertain significance Single submitter
- DDX28 p.Arg213Gly Uncertain significance Single submitter
- DDX28 p.Arg244Leu Uncertain significance Single submitter
- DDX28 p.Arg388Cys Uncertain significance Single submitter
- DDX28 p.Arg52Thr Uncertain significance Single submitter
- DDX28 p.Arg53Gln Likely benign Single submitter
- DDX28 p.Arg5Trp Uncertain significance Single submitter
- DDX28 p.Arg73Gln Uncertain significance Single submitter
- DDX28 p.Asp257Asn Uncertain significance Single submitter
- DDX28 p.Gln48His Uncertain significance Single submitter
- DDX28 p.Gly126Asp Uncertain significance Single submitter
- DDX28 p.Gly132Cys Uncertain significance Single submitter
- DDX28 p.Gly65Glu Uncertain significance Single submitter
- DDX28 p.Gly85Cys Uncertain significance Single submitter
- DDX28 p.His106Arg Uncertain significance Single submitter
- DDX28 p.Ile303Met Uncertain significance Single submitter
- DDX28 p.Ile384Phe Uncertain significance Single submitter
- DDX28 p.Leu12Phe Uncertain significance Single submitter
- DDX28 p.Leu230Phe Uncertain significance Single submitter
- DDX28 p.Leu381Met Uncertain significance Single submitter
- DDX28 p.Leu425Val Uncertain significance Single submitter
- DDX28 p.Leu468Val Uncertain significance Single submitter
- DDX28 p.Lys323Ile Uncertain significance Single submitter
- DDX28 p.Phe282Ser Uncertain significance Single submitter
- DDX28 p.Pro160Leu Uncertain significance Single submitter
- DDX28 p.Pro6Leu Uncertain significance Single submitter
- DDX28 p.Ser124Phe Uncertain significance Single submitter
- DDX28 p.Ser198Phe Uncertain significance Single submitter
- DDX28 p.Ser251Tyr Uncertain significance Single submitter
- DDX28 p.Thr152Ala Uncertain significance Single submitter
- DDX28 p.Tyr472Cys Uncertain significance Single submitter
- DDX28 p.Val154Met Uncertain significance Single submitter
- DDX28 p.Val219Leu Uncertain significance Single submitter
- DDX28 p.Val300Ala Uncertain significance Single submitter
- DDX28 p.Val327Met Uncertain significance Single submitter
- DDX28 p.Val466Met Uncertain significance Single submitter
All DDX28 variants
Likely benign 2
- p.Arg53Gln Single submitter ⚠
- p.Gln150Arg Single submitter
Uncertain significance 72
- p.Ala102Gly Single submitter ⚠
- p.Ala172Thr Single submitter ⚠
- p.Ala216Pro Single submitter ⚠
- p.Ala2Gly Single submitter ⚠
- p.Ala379Val Single submitter ⚠
- p.Arg166Cys Single submitter ⚠
- p.Arg213Gly Single submitter ⚠
- p.Arg244Leu Single submitter ⚠
- p.Arg388Cys Single submitter ⚠
- p.Arg426Ser Single submitter ⚠
- p.Arg436Ser Single submitter ⚠
- p.Arg52Thr Single submitter ⚠
- p.Arg5Trp Single submitter ⚠
- p.Arg73Gln Single submitter ⚠
- p.Arg86Leu Single submitter ⚠
- p.Asp257Asn Single submitter ⚠
- p.Asp293Asn Single submitter ⚠
- p.Asp30Asn Single submitter ⚠
- p.Gln155Arg Single submitter ⚠
- p.Gln279His Single submitter ⚠
- p.Gln339Leu Single submitter ⚠
- p.Gln48His Single submitter ⚠
- p.Glu143Lys Single submitter ⚠
- p.Glu298Gln Single submitter ⚠
- p.Gly126Asp Single submitter ⚠
- p.Gly132Cys Single submitter ⚠
- p.Gly312Arg Single submitter ⚠
- p.Gly65Ala Single submitter ⚠
- p.Gly65Glu Single submitter ⚠
- p.Gly85Cys Single submitter ⚠
- p.His106Arg Single submitter ⚠
- p.His106Tyr Single submitter ⚠
- p.Ile303Met Single submitter ⚠
- p.Ile384Phe Single submitter ⚠
- p.Ile515Met Single submitter ⚠
- p.Leu12Phe Single submitter ⚠
- p.Leu215Phe Single submitter ⚠
- p.Leu230Phe Single submitter ⚠
- p.Leu33Arg Single submitter ⚠
- p.Leu381Met Single submitter ⚠
- p.Leu425Val Single submitter ⚠
- p.Leu42Val Single submitter ⚠
- p.Leu468Val Single submitter ⚠
- p.Leu536Val Single submitter ⚠
- p.Leu61Val Single submitter ⚠
- p.Lys271Arg Single submitter ⚠
- p.Lys323Ile Single submitter ⚠
- p.Met435Leu Single submitter ⚠
- p.Phe282Ser Single submitter ⚠
- p.Phe474Ser Single submitter ⚠
- p.Phe502Ser Single submitter ⚠
- p.Pro160Leu Single submitter ⚠
- p.Pro6Leu Single submitter ⚠
- p.Pro74Gln Single submitter ⚠
- p.Ser123Leu Single submitter ⚠
- p.Ser124Phe Single submitter ⚠
- p.Ser198Phe Single submitter ⚠
- p.Ser251Tyr Single submitter ⚠
- p.Ser99Arg Single submitter ⚠
- p.Thr152Ala Single submitter ⚠
- p.Thr179Ile Single submitter ⚠
- p.Thr179Pro Single submitter ⚠
- p.Thr262Ile Single submitter ⚠
- p.Tyr472Cys Single submitter ⚠
- p.Val154Met Single submitter ⚠
- p.Val219Leu Single submitter ⚠
- p.Val300Ala Single submitter ⚠
- p.Val327Met Single submitter ⚠
- p.Val466Met Single submitter ⚠
- p.Val488Ala Single submitter ⚠
- p.Val503Leu Single submitter ⚠
- p.Val512Phe Single submitter ⚠