DDX31 — 143 ClinVar variants
All ClinVar germline DDX31 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 117 flagged for review →
10 Likely benign · 133 Uncertain significance
Full DDX31 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 117
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 102
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- DDX31 c.139C>T Uncertain significance Single submitter
- DDX31 c.155C>G Uncertain significance Single submitter
- DDX31 c.179C>A Uncertain significance Single submitter
- DDX31 c.185C>T Uncertain significance Single submitter
- DDX31 c.192C>A Uncertain significance Single submitter
- DDX31 c.238C>T Uncertain significance Single submitter
- DDX31 c.247C>G Uncertain significance Single submitter
- DDX31 c.265G>A Uncertain significance Single submitter
- DDX31 c.59G>C Uncertain significance Single submitter
- DDX31 c.77C>A Uncertain significance Single submitter
- DDX31 c.-15T>A Uncertain significance Single submitter
- DDX31 c.-22C>G Uncertain significance Single submitter
- DDX31 c.-27C>G Uncertain significance Single submitter
- DDX31 c.-29T>G Uncertain significance Single submitter
- DDX31 c.-32C>G Uncertain significance Single submitter
- DDX31 c.-39C>T Uncertain significance Single submitter
- DDX31 p.Ala306Thr Uncertain significance Single submitter
- DDX31 p.Ala36Val Uncertain significance Single submitter
- DDX31 p.Ala393Val Uncertain significance Single submitter
- DDX31 p.Ala3Val Uncertain significance Single submitter
- DDX31 p.Ala437Thr Uncertain significance Single submitter
- DDX31 p.Ala4Thr Uncertain significance Single submitter
- DDX31 p.Ala54Gly Uncertain significance Single submitter
- DDX31 p.Ala570Thr Uncertain significance Single submitter
- DDX31 p.Ala575Ser Uncertain significance Single submitter
- DDX31 p.Ala661Thr Uncertain significance Single submitter
- DDX31 p.Arg197Cys Uncertain significance Single submitter
- DDX31 p.Arg249Cys Uncertain significance Single submitter
- DDX31 p.Arg276Gln Uncertain significance Single submitter
- DDX31 p.Arg326Gln Uncertain significance Single submitter
- DDX31 p.Arg447Leu Uncertain significance Single submitter
- DDX31 p.Arg447Pro Uncertain significance Single submitter
- DDX31 p.Arg45Gln Uncertain significance Single submitter
- DDX31 p.Arg462Gly Uncertain significance Single submitter
- DDX31 p.Arg510Gln Uncertain significance Single submitter
- DDX31 p.Arg510Trp Uncertain significance Single submitter
- DDX31 p.Arg516Trp Uncertain significance Single submitter
- DDX31 p.Arg559Ser Uncertain significance Single submitter
- DDX31 p.Arg584Gln Uncertain significance Single submitter
- DDX31 p.Arg631Gln Uncertain significance Single submitter
- DDX31 p.Arg709Pro Uncertain significance Single submitter
- DDX31 p.Arg723Ser Uncertain significance Single submitter
- DDX31 p.Arg86Lys Uncertain significance Single submitter
- DDX31 p.Arg91Gly Uncertain significance Single submitter
- DDX31 p.Asn302Ser Uncertain significance Single submitter
- DDX31 p.Asn47Lys Uncertain significance Single submitter
- DDX31 p.Asn701Ser Uncertain significance Single submitter
- DDX31 p.Asp346Asn Uncertain significance Single submitter
- DDX31 p.Asp346Glu Uncertain significance Single submitter
- DDX31 p.Asp365Asn Uncertain significance Single submitter
- DDX31 p.Asp560Gly Uncertain significance Single submitter
- DDX31 p.Gln347His Uncertain significance Single submitter
- DDX31 p.Gln571Arg Uncertain significance Single submitter
- DDX31 p.Gln673Arg Uncertain significance Single submitter
- DDX31 p.Gln733Arg Uncertain significance Single submitter
- DDX31 p.Glu129Gln Uncertain significance Single submitter
- DDX31 p.Glu357Lys Uncertain significance Single submitter
- DDX31 p.Glu458Lys Uncertain significance Single submitter
- DDX31 p.Glu531Gly Uncertain significance Single submitter
- DDX31 p.Gly704Arg Uncertain significance Single submitter
- DDX31 p.His128Tyr Uncertain significance Single submitter
- DDX31 p.His333Arg Uncertain significance Single submitter
- DDX31 p.Ile254Met Uncertain significance Single submitter
- DDX31 p.Ile300Leu Uncertain significance Single submitter
- DDX31 p.Ile372Val Uncertain significance Single submitter
- DDX31 p.Ile581Met Uncertain significance Single submitter
- DDX31 p.Ile581Val Uncertain significance Single submitter
- DDX31 p.Ile94Asn Uncertain significance Single submitter
- DDX31 p.Leu417Val Uncertain significance Single submitter
- DDX31 p.Leu451Pro Uncertain significance Single submitter
- DDX31 p.Leu635Val Uncertain significance Single submitter
- DDX31 p.Lys250Glu Uncertain significance Single submitter
- DDX31 p.Lys745Arg Uncertain significance Single submitter
- DDX31 p.Met191Val Uncertain significance Single submitter
- DDX31 p.Met457Val Uncertain significance Single submitter
- DDX31 p.Met690Val Uncertain significance Single submitter
- DDX31 p.Pro208Ser Uncertain significance Single submitter
- DDX31 p.Pro350Ser Uncertain significance Single submitter
- DDX31 p.Pro436Leu Uncertain significance Single submitter
- DDX31 p.Pro578Arg Uncertain significance Single submitter
- DDX31 p.Pro717Leu Uncertain significance Single submitter
- DDX31 p.Pro719Leu Uncertain significance Single submitter
- DDX31 p.Ser151Arg Uncertain significance Single submitter
- DDX31 p.Ser431Arg Uncertain significance Single submitter
- DDX31 p.Ser599Gly Uncertain significance Single submitter
- DDX31 p.Ser652Thr Uncertain significance Single submitter
- DDX31 p.Ser687Ala Uncertain significance Single submitter
- DDX31 p.Ser740Asn Uncertain significance Single submitter
- DDX31 p.Thr269Ile Uncertain significance Single submitter
- DDX31 p.Thr57Ala Uncertain significance Single submitter
- DDX31 p.Thr57Pro Uncertain significance Single submitter
- DDX31 p.Thr57Ser Uncertain significance Single submitter
- DDX31 p.Thr590Lys Uncertain significance Single submitter
- DDX31 p.Thr590Met Uncertain significance Single submitter
- DDX31 p.Thr65Ser Uncertain significance Single submitter
- DDX31 p.Thr672Ile Uncertain significance Single submitter
- DDX31 p.Thr83Ile Uncertain significance Single submitter
- DDX31 p.Trp605Arg Uncertain significance Single submitter
- DDX31 p.Val380Ala Uncertain significance Single submitter
- DDX31 p.Val545Ile Uncertain significance Single submitter
- DDX31 p.Val576Phe Uncertain significance Single submitter
- DDX31 p.Val59Asp Uncertain significance Single submitter
Predictors split 15
The independent predictors disagree with each other — read with care.
- DDX31 p.Arg197Leu Uncertain significance Single submitter
- DDX31 p.Arg276Trp Uncertain significance Single submitter
- DDX31 p.Arg278Trp Uncertain significance Single submitter
- DDX31 p.Arg326Trp Uncertain significance Single submitter
- DDX31 p.Arg388Ser Uncertain significance Single submitter
- DDX31 p.Arg452Trp Uncertain significance Single submitter
- DDX31 p.Arg45Trp Uncertain significance Single submitter
- DDX31 p.Arg485Trp Uncertain significance Single submitter
- DDX31 p.Gln171His Uncertain significance Single submitter
- DDX31 p.Leu397His Uncertain significance Single submitter
- DDX31 p.Leu635Phe Uncertain significance Single submitter
- DDX31 p.Phe402Leu Uncertain significance Single submitter
- DDX31 p.Pro104Ala Uncertain significance Single submitter
- DDX31 p.Thr142Met Uncertain significance Single submitter
- DDX31 p.Val382Ala Uncertain significance Single submitter
All DDX31 variants
Likely benign 10
- c.132T>G Single submitter
- c.220G>A Single submitter
- p.Ala695= Single submitter
- p.Arg287= Single submitter
- p.Arg474Thr Single submitter
- p.Asn544= Single submitter
- p.Asn69Lys Single submitter
- p.Gln356Arg Single submitter
- p.His128Gln Single submitter
- p.Ser80Leu Single submitter
Uncertain significance 133
- c.139C>T Single submitter ⚠
- c.149C>T Single submitter
- c.154C>G Single submitter
- c.155C>G Single submitter ⚠
- c.170C>T Single submitter
- c.175G>C Single submitter
- c.179C>A Single submitter ⚠
- c.185C>T Single submitter ⚠
- c.192C>A Single submitter ⚠
- c.238C>T Single submitter ⚠
- c.244C>T Single submitter
- c.247C>G Single submitter ⚠
- c.265G>A Single submitter ⚠
- c.28C>T Single submitter
- c.59G>C Single submitter ⚠
- c.5C>T Single submitter
- c.61C>T Single submitter
- c.77C>A Single submitter ⚠
- c.-15T>A Single submitter ⚠
- c.-22C>G Single submitter ⚠
- c.-27C>G Single submitter ⚠
- c.-29T>G Single submitter ⚠
- c.-32C>G Single submitter ⚠
- c.-39C>T Single submitter ⚠
- p.Ala306Thr Single submitter ⚠
- p.Ala36Val Single submitter ⚠
- p.Ala393Val Single submitter ⚠
- p.Ala3Val Single submitter ⚠
- p.Ala437Thr Single submitter ⚠
- p.Ala4Thr Single submitter ⚠
- p.Ala54Gly Single submitter ⚠
- p.Ala570Thr Single submitter ⚠
- p.Ala575Ser Single submitter ⚠
- p.Ala661Thr Single submitter ⚠
- p.Arg197Cys Single submitter ⚠
- p.Arg197Leu Single submitter ⚠
- p.Arg249Cys Single submitter ⚠
- p.Arg276Gln Single submitter ⚠
- p.Arg276Trp Single submitter ⚠
- p.Arg278Trp Single submitter ⚠
- p.Arg326Gln Single submitter ⚠
- p.Arg326Trp Single submitter ⚠
- p.Arg388Ser Single submitter ⚠
- p.Arg447Leu Single submitter ⚠
- p.Arg447Pro Single submitter ⚠
- p.Arg452Trp Single submitter ⚠
- p.Arg45Gln Single submitter ⚠
- p.Arg45Trp Single submitter ⚠
- p.Arg462Gly Single submitter ⚠
- p.Arg485Trp Single submitter ⚠
- p.Arg510Gln Single submitter ⚠
- p.Arg510Trp Single submitter ⚠
- p.Arg516Trp Single submitter ⚠
- p.Arg559Ser Single submitter ⚠
- p.Arg584Gln Single submitter ⚠
- p.Arg631Gln Single submitter ⚠
- p.Arg709Pro Single submitter ⚠
- p.Arg723Ser Single submitter ⚠
- p.Arg86Lys Single submitter ⚠
- p.Arg91Gly Single submitter ⚠
- p.Asn253His Single submitter
- p.Asn302Ser Single submitter ⚠
- p.Asn47Lys Single submitter ⚠
- p.Asn701Ser Single submitter ⚠
- p.Asp346Asn Single submitter ⚠
- p.Asp346Glu Single submitter ⚠
- p.Asp365Asn Single submitter ⚠
- p.Asp560Gly Single submitter ⚠
- p.Cys400Arg Single submitter
- p.Gln171His Single submitter ⚠
- p.Gln347His Single submitter ⚠
- p.Gln571Arg Single submitter ⚠
- p.Gln673Arg Single submitter ⚠
- p.Gln733Arg Single submitter ⚠
- p.Glu129Gln Single submitter ⚠
- p.Glu357Lys Single submitter ⚠
- p.Glu458Lys Single submitter ⚠
- p.Glu531Gly Single submitter ⚠
- p.Gly704Arg Single submitter ⚠
- p.His128Tyr Single submitter ⚠
- p.His333Arg Single submitter ⚠
- p.Ile157Phe Single submitter
- p.Ile254Met Single submitter ⚠
- p.Ile300Leu Single submitter ⚠
- p.Ile330Ser Single submitter
- p.Ile330Thr Single submitter
- p.Ile372Val Single submitter ⚠
- p.Ile581Met Single submitter ⚠
- p.Ile581Val Single submitter ⚠
- p.Ile94Asn Single submitter ⚠
- p.Leu397His Single submitter ⚠
- p.Leu417Val Single submitter ⚠
- p.Leu451Pro Single submitter ⚠
- p.Leu635Phe Single submitter ⚠
- p.Leu635Val Single submitter ⚠
- p.Lys250Glu Single submitter ⚠
- p.Lys745Arg Single submitter ⚠
- p.Met191Val Single submitter ⚠
- p.Met457Val Single submitter ⚠
- p.Met690Val Single submitter ⚠
- p.Phe402Leu Single submitter ⚠
- p.Pro104Ala Single submitter ⚠
- p.Pro208Ser Single submitter ⚠
- p.Pro350Ser Single submitter ⚠
- p.Pro436Leu Single submitter ⚠
- p.Pro490Arg Single submitter
- p.Pro578Arg Single submitter ⚠
- p.Pro717Leu Single submitter ⚠
- p.Pro719Leu Single submitter ⚠
- p.Ser151Arg Single submitter ⚠
- p.Ser431Arg Single submitter ⚠
- p.Ser599Gly Single submitter ⚠
- p.Ser652Thr Single submitter ⚠
- p.Ser687Ala Single submitter ⚠
- p.Ser740Asn Single submitter ⚠
- p.Thr142Met Single submitter ⚠
- p.Thr209Ala Single submitter
- p.Thr269Ile Single submitter ⚠
- p.Thr57Ala Single submitter ⚠
- p.Thr57Pro Single submitter ⚠
- p.Thr57Ser Single submitter ⚠
- p.Thr590Lys Single submitter ⚠
- p.Thr590Met Single submitter ⚠
- p.Thr65Ser Single submitter ⚠
- p.Thr672Ile Single submitter ⚠
- p.Thr83Ile Single submitter ⚠
- p.Trp605Arg Single submitter ⚠
- p.Val207Met Single submitter
- p.Val380Ala Single submitter ⚠
- p.Val382Ala Single submitter ⚠
- p.Val545Ile Single submitter ⚠
- p.Val576Phe Single submitter ⚠
- p.Val59Asp Single submitter ⚠