DDX50 — 87 ClinVar variants
All ClinVar germline DDX50 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 85 flagged for review →
2 Benign · 85 Uncertain significance
Full DDX50 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 85
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 47
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- DDX50 p.Ala138Asp Uncertain significance Single submitter
- DDX50 p.Ala241Val Uncertain significance Single submitter
- DDX50 p.Ala392Ser Uncertain significance Single submitter
- DDX50 p.Arg182Trp Uncertain significance Single submitter
- DDX50 p.Arg210Cys Uncertain significance Single submitter
- DDX50 p.Arg269Pro Uncertain significance Single submitter
- DDX50 p.Arg285Gln Uncertain significance Single submitter
- DDX50 p.Arg344Gly Uncertain significance Single submitter
- DDX50 p.Arg475Cys Uncertain significance Single submitter
- DDX50 p.Arg475His Uncertain significance Single submitter
- DDX50 p.Arg532Gly Uncertain significance Single submitter
- DDX50 p.Arg643Lys Uncertain significance Single submitter
- DDX50 p.Asn615Thr Uncertain significance Single submitter
- DDX50 p.Asp55Glu Uncertain significance Single submitter
- DDX50 p.Asp650Asn Uncertain significance Single submitter
- DDX50 p.Asp716Gly Uncertain significance Single submitter
- DDX50 p.Gln23Pro Uncertain significance Single submitter
- DDX50 p.Glu19Lys Uncertain significance Single submitter
- DDX50 p.Glu291Asp Uncertain significance Single submitter
- DDX50 p.Glu663Asp Uncertain significance Single submitter
- DDX50 p.Gly480Asp Uncertain significance Single submitter
- DDX50 p.Gly708Arg Uncertain significance Single submitter
- DDX50 p.Gly730Arg Uncertain significance Single submitter
- DDX50 p.Gly77Arg Uncertain significance Single submitter
- DDX50 p.His364Leu Uncertain significance Single submitter
- DDX50 p.His37Gln Uncertain significance Single submitter
- DDX50 p.His474Leu Uncertain significance Single submitter
- DDX50 p.Ile101Thr Uncertain significance Single submitter
- DDX50 p.Ile149Leu Uncertain significance Single submitter
- DDX50 p.Ile234Val Uncertain significance Single submitter
- DDX50 p.Leu217Ser Uncertain significance Single submitter
- DDX50 p.Leu6Pro Uncertain significance Single submitter
- DDX50 p.Met520Val Uncertain significance Single submitter
- DDX50 p.Met528Leu Uncertain significance Single submitter
- DDX50 p.Met66Thr Uncertain significance Single submitter
- DDX50 p.Phe243Ser Uncertain significance Single submitter
- DDX50 p.Pro16Leu Uncertain significance Single submitter
- DDX50 p.Pro219Leu Uncertain significance Single submitter
- DDX50 p.Ser190Cys Uncertain significance Single submitter
- DDX50 p.Thr220Ala Uncertain significance Single submitter
- DDX50 p.Thr519Ser Uncertain significance Single submitter
- DDX50 p.Trp7Gly Uncertain significance Single submitter
- DDX50 p.Trp7Ser Uncertain significance Single submitter
- DDX50 p.Tyr385Cys Uncertain significance Single submitter
- DDX50 p.Tyr472Cys Uncertain significance Single submitter
- DDX50 p.Tyr668Asp Uncertain significance Single submitter
-
DDX50 p.Ser41Leu
Uncertain significance
No assertion criteria
prostate cancer
Predictors split 38
The independent predictors disagree with each other — read with care.
- DDX50 p.Ala138Gly Uncertain significance Single submitter
- DDX50 p.Ala406Gly Uncertain significance Single submitter
- DDX50 p.Arg132His Uncertain significance Single submitter
- DDX50 p.Arg182Gln Uncertain significance Single submitter
- DDX50 p.Arg278Gln Uncertain significance Single submitter
- DDX50 p.Arg686Gln Uncertain significance Single submitter
- DDX50 p.Arg696Gln Uncertain significance Single submitter
- DDX50 p.Arg696Leu Uncertain significance Single submitter
- DDX50 p.Arg700Trp Uncertain significance Single submitter
- DDX50 p.Arg703Lys Uncertain significance Single submitter
- DDX50 p.Arg724Thr Uncertain significance Single submitter
- DDX50 p.Arg734Trp Uncertain significance Single submitter
- DDX50 p.Asn141Ser Uncertain significance Single submitter
- DDX50 p.Asn319Ser Uncertain significance Single submitter
- DDX50 p.Asp55Ala Uncertain significance Single submitter
- DDX50 p.Gln134Arg Uncertain significance Single submitter
- DDX50 p.Glu136Gly Uncertain significance Single submitter
- DDX50 p.Glu665Lys Uncertain significance Single submitter
- DDX50 p.Gly51Asp Uncertain significance Single submitter
- DDX50 p.Gly628Ala Uncertain significance Single submitter
- DDX50 p.Gly628Glu Uncertain significance Single submitter
- DDX50 p.Gly685Arg Uncertain significance Single submitter
- DDX50 p.Gly699Ser Uncertain significance Single submitter
- DDX50 p.Ile178Val Uncertain significance Single submitter
- DDX50 p.Leu661Ile Uncertain significance Single submitter
- DDX50 p.Lys24Met Uncertain significance Single submitter
- DDX50 p.Lys25Glu Uncertain significance Single submitter
- DDX50 p.Lys400Asn Uncertain significance Single submitter
- DDX50 p.Ser117Cys Uncertain significance Single submitter
- DDX50 p.Ser117Phe Uncertain significance Single submitter
- DDX50 p.Ser140Phe Uncertain significance Single submitter
- DDX50 p.Ser211Leu Uncertain significance Single submitter
- DDX50 p.Ser613Asn Uncertain significance Single submitter
- DDX50 p.Ser680Asn Uncertain significance Single submitter
- DDX50 p.Thr510Ala Uncertain significance Single submitter
- DDX50 p.Thr621Ile Uncertain significance Single submitter
- DDX50 p.Tyr159His Uncertain significance Single submitter
- DDX50 p.Tyr172Cys Uncertain significance Single submitter
All DDX50 variants
Benign 2
- p.Ala659Thr Multiple submitters
- p.Ser239= Multiple submitters
Uncertain significance 85
- p.Ala138Asp Single submitter ⚠
- p.Ala138Gly Single submitter ⚠
- p.Ala241Val Single submitter ⚠
- p.Ala392Ser Single submitter ⚠
- p.Ala406Gly Single submitter ⚠
- p.Arg132His Single submitter ⚠
- p.Arg182Gln Single submitter ⚠
- p.Arg182Trp Single submitter ⚠
- p.Arg210Cys Single submitter ⚠
- p.Arg269Pro Single submitter ⚠
- p.Arg278Gln Single submitter ⚠
- p.Arg285Gln Single submitter ⚠
- p.Arg344Gly Single submitter ⚠
- p.Arg475Cys Single submitter ⚠
- p.Arg475His Single submitter ⚠
- p.Arg532Gly Single submitter ⚠
- p.Arg643Lys Single submitter ⚠
- p.Arg686Gln Single submitter ⚠
- p.Arg696Gln Single submitter ⚠
- p.Arg696Leu Single submitter ⚠
- p.Arg700Trp Single submitter ⚠
- p.Arg703Lys Single submitter ⚠
- p.Arg724Thr Single submitter ⚠
- p.Arg734Trp Single submitter ⚠
- p.Asn141Ser Single submitter ⚠
- p.Asn319Ser Single submitter ⚠
- p.Asn615Thr Single submitter ⚠
- p.Asp55Ala Single submitter ⚠
- p.Asp55Glu Single submitter ⚠
- p.Asp650Asn Single submitter ⚠
- p.Asp716Gly Single submitter ⚠
- p.Gln134Arg Single submitter ⚠
- p.Gln23Pro Single submitter ⚠
- p.Glu136Gly Single submitter ⚠
- p.Glu19Lys Single submitter ⚠
- p.Glu291Asp Single submitter ⚠
- p.Glu663Asp Single submitter ⚠
- p.Glu665Lys Single submitter ⚠
- p.Gly480Asp Single submitter ⚠
- p.Gly51Asp Single submitter ⚠
- p.Gly628Ala Single submitter ⚠
- p.Gly628Glu Single submitter ⚠
- p.Gly685Arg Single submitter ⚠
- p.Gly699Ser Single submitter ⚠
- p.Gly708Arg Single submitter ⚠
- p.Gly730Arg Single submitter ⚠
- p.Gly77Arg Single submitter ⚠
- p.His364Leu Single submitter ⚠
- p.His37Gln Single submitter ⚠
- p.His474Leu Single submitter ⚠
- p.Ile101Thr Single submitter ⚠
- p.Ile149Leu Single submitter ⚠
- p.Ile178Val Single submitter ⚠
- p.Ile234Val Single submitter ⚠
- p.Leu217Ser Single submitter ⚠
- p.Leu661Ile Single submitter ⚠
- p.Leu6Pro Single submitter ⚠
- p.Lys24Met Single submitter ⚠
- p.Lys25Glu Single submitter ⚠
- p.Lys400Asn Single submitter ⚠
- p.Met520Val Single submitter ⚠
- p.Met528Leu Single submitter ⚠
- p.Met66Thr Single submitter ⚠
- p.Phe243Ser Single submitter ⚠
- p.Pro16Leu Single submitter ⚠
- p.Pro219Leu Single submitter ⚠
- p.Ser117Cys Single submitter ⚠
- p.Ser117Phe Single submitter ⚠
- p.Ser140Phe Single submitter ⚠
- p.Ser190Cys Single submitter ⚠
- p.Ser211Leu Single submitter ⚠
- p.Ser613Asn Single submitter ⚠
- p.Ser680Asn Single submitter ⚠
- p.Thr220Ala Single submitter ⚠
- p.Thr510Ala Single submitter ⚠
- p.Thr519Ser Single submitter ⚠
- p.Thr621Ile Single submitter ⚠
- p.Trp7Gly Single submitter ⚠
- p.Trp7Ser Single submitter ⚠
- p.Tyr159His Single submitter ⚠
- p.Tyr172Cys Single submitter ⚠
- p.Tyr385Cys Single submitter ⚠
- p.Tyr472Cys Single submitter ⚠
- p.Tyr668Asp Single submitter ⚠
- p.Ser41Leu No assertion criteria prostate cancer ⚠