DDX55 — 93 ClinVar variants
All ClinVar germline DDX55 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 89 flagged for review →
4 Likely benign · 89 Uncertain significance
Full DDX55 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 89
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 74
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- DDX55 p.Ala153Asp Uncertain significance Single submitter
- DDX55 p.Ala215Val Uncertain significance Single submitter
- DDX55 p.Ala235Val Uncertain significance Single submitter
- DDX55 p.Ala38Thr Uncertain significance Single submitter
- DDX55 p.Ala401Pro Uncertain significance Single submitter
- DDX55 p.Ala456Pro Uncertain significance Single submitter
- DDX55 p.Arg144Cys Uncertain significance Single submitter
- DDX55 p.Arg218Gln Uncertain significance Single submitter
- DDX55 p.Arg241Cys Uncertain significance Single submitter
- DDX55 p.Arg241His Uncertain significance Single submitter
- DDX55 p.Arg307Cys Uncertain significance Single submitter
- DDX55 p.Arg330Gln Uncertain significance Single submitter
- DDX55 p.Arg330Trp Uncertain significance Single submitter
- DDX55 p.Arg355Cys Uncertain significance Single submitter
- DDX55 p.Arg358His Uncertain significance Single submitter
- DDX55 p.Arg442Ile Uncertain significance Single submitter
- DDX55 p.Arg559Gly Uncertain significance Single submitter
- DDX55 p.Asn308Ser Uncertain significance Single submitter
- DDX55 p.Asn338Ile Uncertain significance Single submitter
- DDX55 p.Asn386Ser Uncertain significance Single submitter
- DDX55 p.Asp171His Uncertain significance Single submitter
- DDX55 p.Asp545Ala Uncertain significance Single submitter
- DDX55 p.Asp595Asn Uncertain significance Single submitter
- DDX55 p.Asp599Asn Uncertain significance Single submitter
- DDX55 p.Asp99Gly Uncertain significance Single submitter
- DDX55 p.Cys279Arg Uncertain significance Single submitter
- DDX55 p.Cys389Gly Uncertain significance Single submitter
- DDX55 p.Glu10Asp Uncertain significance Single submitter
- DDX55 p.Glu243Lys Uncertain significance Single submitter
- DDX55 p.Glu26Gln Uncertain significance Single submitter
- DDX55 p.Glu500Gln Uncertain significance Single submitter
- DDX55 p.Glu536Ala Uncertain significance Single submitter
- DDX55 p.Glu69Gly Uncertain significance Single submitter
- DDX55 p.Glu6Gln Uncertain significance Single submitter
- DDX55 p.Gly229Ser Uncertain significance Single submitter
- DDX55 p.Gly357Ser Uncertain significance Single submitter
- DDX55 p.Gly365Arg Uncertain significance Single submitter
- DDX55 p.Gly454Asp Uncertain significance Single submitter
- DDX55 p.His108Asp Uncertain significance Single submitter
- DDX55 p.His260Arg Uncertain significance Single submitter
- DDX55 p.His435Arg Uncertain significance Single submitter
- DDX55 p.Ile380Ser Uncertain significance Single submitter
- DDX55 p.Ile385Leu Uncertain significance Single submitter
- DDX55 p.Leu16Val Uncertain significance Single submitter
- DDX55 p.Leu458Pro Uncertain significance Single submitter
- DDX55 p.Leu94Val Uncertain significance Single submitter
- DDX55 p.Lys250Met Uncertain significance Single submitter
- DDX55 p.Lys462Arg Uncertain significance Single submitter
- DDX55 p.Lys506Glu Uncertain significance Single submitter
- DDX55 p.Lys587Asn Uncertain significance Single submitter
- DDX55 p.Lys587Glu Uncertain significance Single submitter
- DDX55 p.Met312Ile Uncertain significance Single submitter
- DDX55 p.Met375Val Uncertain significance Single submitter
- DDX55 p.Met410Val Uncertain significance Single submitter
- DDX55 p.Phe181Cys Uncertain significance Single submitter
- DDX55 p.Phe515Ser Uncertain significance Single submitter
- DDX55 p.Pro18Ala Uncertain significance Single submitter
- DDX55 p.Pro18Ser Uncertain significance Single submitter
- DDX55 p.Pro239Ser Uncertain significance Single submitter
- DDX55 p.Pro461Ser Uncertain significance Single submitter
- DDX55 p.Pro476Ala Uncertain significance Single submitter
- DDX55 p.Ser164Thr Uncertain significance Single submitter
- DDX55 p.Ser450Arg Uncertain significance Single submitter
- DDX55 p.Thr276Ile Uncertain significance Single submitter
- DDX55 p.Thr325Ile Uncertain significance Single submitter
- DDX55 p.Thr359Ile Uncertain significance Single submitter
- DDX55 p.Thr483Met Uncertain significance Single submitter
- DDX55 p.Tyr305Cys Uncertain significance Single submitter
- DDX55 p.Val221Ile Uncertain significance Single submitter
- DDX55 p.Val225Glu Uncertain significance Single submitter
- DDX55 p.Val230Met Uncertain significance Single submitter
- DDX55 p.Val259Ile Uncertain significance Single submitter
- DDX55 p.Val294Met Uncertain significance Single submitter
- DDX55 p.Val477Met Uncertain significance Single submitter
Predictors split 15
The independent predictors disagree with each other — read with care.
- DDX55 p.Arg315Cys Uncertain significance Single submitter
- DDX55 p.Arg315His Uncertain significance Single submitter
- DDX55 p.Cys249Gly Uncertain significance Single submitter
- DDX55 p.Glu100Lys Uncertain significance Single submitter
- DDX55 p.Gly365Trp Uncertain significance Single submitter
- DDX55 p.Ile299Met Uncertain significance Single submitter
- DDX55 p.Leu439Gln Uncertain significance Single submitter
- DDX55 p.Leu71Ile Uncertain significance Single submitter
- DDX55 p.Lys525Asn Uncertain significance Single submitter
- DDX55 p.Phe418Ser Uncertain significance Single submitter
- DDX55 p.Ser350Arg Uncertain significance Single submitter
- DDX55 p.Ser8Phe Uncertain significance Single submitter
- DDX55 p.Thr106Arg Uncertain significance Single submitter
- DDX55 p.Thr106Met Uncertain significance Single submitter
- DDX55 p.Thr39Ile Uncertain significance Single submitter
All DDX55 variants
Likely benign 4
- p.Arg398Lys Single submitter
- p.Arg453Gln Single submitter
- p.Arg513Lys Single submitter
- p.Asn381Ser Single submitter
Uncertain significance 89
- p.Ala153Asp Single submitter ⚠
- p.Ala215Val Single submitter ⚠
- p.Ala235Val Single submitter ⚠
- p.Ala38Thr Single submitter ⚠
- p.Ala401Pro Single submitter ⚠
- p.Ala456Pro Single submitter ⚠
- p.Arg144Cys Single submitter ⚠
- p.Arg218Gln Single submitter ⚠
- p.Arg241Cys Single submitter ⚠
- p.Arg241His Single submitter ⚠
- p.Arg307Cys Single submitter ⚠
- p.Arg315Cys Single submitter ⚠
- p.Arg315His Single submitter ⚠
- p.Arg330Gln Single submitter ⚠
- p.Arg330Trp Single submitter ⚠
- p.Arg355Cys Single submitter ⚠
- p.Arg358His Single submitter ⚠
- p.Arg442Ile Single submitter ⚠
- p.Arg559Gly Single submitter ⚠
- p.Asn308Ser Single submitter ⚠
- p.Asn338Ile Single submitter ⚠
- p.Asn386Ser Single submitter ⚠
- p.Asp171His Single submitter ⚠
- p.Asp545Ala Single submitter ⚠
- p.Asp595Asn Single submitter ⚠
- p.Asp599Asn Single submitter ⚠
- p.Asp99Gly Single submitter ⚠
- p.Cys249Gly Single submitter ⚠
- p.Cys279Arg Single submitter ⚠
- p.Cys389Gly Single submitter ⚠
- p.Glu100Lys Single submitter ⚠
- p.Glu10Asp Single submitter ⚠
- p.Glu243Lys Single submitter ⚠
- p.Glu26Gln Single submitter ⚠
- p.Glu500Gln Single submitter ⚠
- p.Glu536Ala Single submitter ⚠
- p.Glu69Gly Single submitter ⚠
- p.Glu6Gln Single submitter ⚠
- p.Gly229Ser Single submitter ⚠
- p.Gly357Ser Single submitter ⚠
- p.Gly365Arg Single submitter ⚠
- p.Gly365Trp Single submitter ⚠
- p.Gly454Asp Single submitter ⚠
- p.His108Asp Single submitter ⚠
- p.His260Arg Single submitter ⚠
- p.His435Arg Single submitter ⚠
- p.Ile299Met Single submitter ⚠
- p.Ile380Ser Single submitter ⚠
- p.Ile385Leu Single submitter ⚠
- p.Leu16Val Single submitter ⚠
- p.Leu439Gln Single submitter ⚠
- p.Leu458Pro Single submitter ⚠
- p.Leu71Ile Single submitter ⚠
- p.Leu94Val Single submitter ⚠
- p.Lys250Met Single submitter ⚠
- p.Lys462Arg Single submitter ⚠
- p.Lys506Glu Single submitter ⚠
- p.Lys525Asn Single submitter ⚠
- p.Lys587Asn Single submitter ⚠
- p.Lys587Glu Single submitter ⚠
- p.Met312Ile Single submitter ⚠
- p.Met375Val Single submitter ⚠
- p.Met410Val Single submitter ⚠
- p.Phe181Cys Single submitter ⚠
- p.Phe418Ser Single submitter ⚠
- p.Phe515Ser Single submitter ⚠
- p.Pro18Ala Single submitter ⚠
- p.Pro18Ser Single submitter ⚠
- p.Pro239Ser Single submitter ⚠
- p.Pro461Ser Single submitter ⚠
- p.Pro476Ala Single submitter ⚠
- p.Ser164Thr Single submitter ⚠
- p.Ser350Arg Single submitter ⚠
- p.Ser450Arg Single submitter ⚠
- p.Ser8Phe Single submitter ⚠
- p.Thr106Arg Single submitter ⚠
- p.Thr106Met Single submitter ⚠
- p.Thr276Ile Single submitter ⚠
- p.Thr325Ile Single submitter ⚠
- p.Thr359Ile Single submitter ⚠
- p.Thr39Ile Single submitter ⚠
- p.Thr483Met Single submitter ⚠
- p.Tyr305Cys Single submitter ⚠
- p.Val221Ile Single submitter ⚠
- p.Val225Glu Single submitter ⚠
- p.Val230Met Single submitter ⚠
- p.Val259Ile Single submitter ⚠
- p.Val294Met Single submitter ⚠
- p.Val477Met Single submitter ⚠