DENND2B — 199 ClinVar variants

All ClinVar germline DENND2B variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 167 flagged for review →

9 Benign · 1 Benign/Likely benign · 9 Likely benign · 180 Uncertain significance

Full DENND2B gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 167

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors lean, ClinVar uncertain 139

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

Predictors split 28

The independent predictors disagree with each other — read with care.

All DENND2B variants

Benign 9

c.3379+7G>A Multiple submitters
p.Ala823Thr Multiple submitters
p.Arg250Gln Multiple submitters
p.His670= Multiple submitters
p.Pro420= Multiple submitters
c.2353-450A>C Single submitter
c.-25-25462_-25-25461insGGGTGTGTGTGTGTGTGTGT Single submitter
c.-25-25462_-25-25461insGGGTGTGTGTGTGT Single submitter
c.-25-25462_-25-25461insGGGTGTGTGTGTGTGT Single submitter

Benign/Likely benign 1

c.81-4C>A Multiple submitters

Likely benign 9

c.-25-25461_-25-25460insGTTGT Single submitter
p.Ala97Thr Single submitter
p.Gly329Ser Single submitter
p.Leu151Phe Single submitter
p.Phe94Leu Single submitter
p.Pro141Leu Single submitter
p.Pro944= Single submitter
p.Ser539Asn Single submitter
p.Val883Ala Single submitter

Uncertain significance 180

p.Arg312Gln Multiple submitters ⚠
p.Ala113Gly Single submitter ⚠
p.Ala113Thr Single submitter ⚠
p.Ala121Thr Single submitter ⚠
p.Ala135Val Single submitter ⚠
p.Ala398Val Single submitter ⚠
p.Ala418Thr Single submitter ⚠
p.Ala54Val Single submitter ⚠
p.Ala610Asp Single submitter ⚠
p.Arg1002Thr Single submitter ⚠
p.Arg1057Gln Single submitter ⚠
p.Arg1061Cys Single submitter
p.Arg1061His Single submitter ⚠
p.Arg1071His Single submitter ⚠
p.Arg1095Gln Single submitter ⚠
p.Arg165fs Single submitter
p.Arg165Trp Single submitter
p.Arg174Pro Single submitter
p.Arg226Trp Single submitter ⚠
p.Arg227Lys Single submitter ⚠
p.Arg22Gln Single submitter ⚠
p.Arg250Trp Single submitter ⚠
p.Arg255Gln Single submitter ⚠
p.Arg270Ser Single submitter ⚠
p.Arg275Ser Single submitter ⚠
p.Arg432Gln Single submitter ⚠
p.Arg509Gln Single submitter ⚠
p.Arg513Ter Single submitter
p.Arg528Gly Single submitter ⚠
p.Arg565Gln Single submitter ⚠
p.Arg565Trp Single submitter ⚠
p.Arg568Gln Single submitter ⚠
p.Arg572Ser Single submitter ⚠
p.Arg608His Single submitter ⚠
p.Arg609Gln Single submitter ⚠
p.Arg609Trp Single submitter ⚠
p.Arg612Cys Single submitter ⚠
p.Arg612His Single submitter ⚠
p.Arg64Trp Single submitter ⚠
p.Arg667Cys Single submitter ⚠
p.Arg667His Single submitter ⚠
p.Arg677Cys Single submitter ⚠
p.Arg677His Single submitter ⚠
p.Arg682Cys Single submitter ⚠
p.Arg711Gln Single submitter ⚠
p.Arg727Gln Single submitter ⚠
p.Arg801Cys Single submitter ⚠
p.Arg817Cys Single submitter
p.Arg817Leu Single submitter ⚠
p.Arg868Thr Single submitter ⚠
p.Arg898Gln Single submitter ⚠
p.Arg976Ter Single submitter
p.Asn408Ser Single submitter ⚠
p.Asn557Lys Single submitter ⚠
p.Asn712Tyr Single submitter ⚠
p.Asp1016Asn Single submitter ⚠
p.Asp1017Asn Single submitter ⚠
p.Asp221Tyr Single submitter
p.Asp381His Single submitter ⚠
p.Asp524Asn Single submitter ⚠
p.Asp82Val Single submitter ⚠
p.Asp982Asn Single submitter ⚠
p.Cys201Ser Single submitter ⚠
p.Cys235Tyr Single submitter ⚠
p.Gln1087His Single submitter ⚠
p.Gln474Glu Single submitter ⚠
p.Gln744Arg Single submitter ⚠
p.Gln81Glu Single submitter ⚠
p.Glu1005Lys Single submitter ⚠
p.Glu1105Asp Single submitter ⚠
p.Glu186Gly Single submitter ⚠
p.Glu189Gln Single submitter ⚠
p.Glu234Lys Single submitter ⚠
p.Glu294Lys Single submitter ⚠
p.Glu355Asp Single submitter ⚠
p.Glu560Gln Single submitter ⚠
p.Glu758Gln Single submitter ⚠
p.Glu875Lys Single submitter ⚠
p.Glu965Ala Single submitter ⚠
p.Gly100Asp Single submitter ⚠
p.Gly142Ala Single submitter ⚠
p.Gly142Arg Single submitter ⚠
p.Gly149Arg Single submitter ⚠
p.Gly806Ser Single submitter ⚠
p.Gly855Ala Single submitter ⚠
p.His160Gln Single submitter ⚠
p.His573Gln Single submitter ⚠
p.His71Gln Single submitter ⚠
p.His914Gln Single submitter ⚠
p.Ile641Thr Single submitter ⚠
p.Ile887Ser Single submitter
p.Ile938Thr Single submitter
p.Leu1022Pro Single submitter ⚠
p.Leu1123Phe Single submitter ⚠
p.Leu282Arg Single submitter ⚠
p.Leu422Val Single submitter ⚠
p.Leu458Val Single submitter ⚠
p.Leu523Trp Single submitter ⚠
p.Leu586Val Single submitter ⚠
p.Leu598Phe Single submitter ⚠
p.Leu616Arg Single submitter ⚠
p.Leu696Val Single submitter ⚠
p.Leu725Val Single submitter ⚠
p.Lys218Glu Single submitter ⚠
p.Lys223Asn Single submitter ⚠
p.Lys361Asn Single submitter ⚠
p.Lys391Met Single submitter ⚠
p.Lys627Arg Single submitter ⚠
p.Lys724Arg Single submitter ⚠
p.Lys846Glu Single submitter ⚠
p.Met1077Val Single submitter ⚠
p.Met181Ile Single submitter ⚠
p.Phe766Leu Single submitter ⚠
p.Pro147Ala Single submitter ⚠
p.Pro147Ser Single submitter ⚠
p.Pro179Arg Single submitter ⚠
p.Pro207Ser Single submitter ⚠
p.Pro211fs Single submitter
p.Pro21Ser Single submitter ⚠
p.Pro238Ser Single submitter ⚠
p.Pro351Ser Single submitter ⚠
p.Pro352Arg Single submitter ⚠
p.Pro411Ser Single submitter ⚠
p.Pro466Ala Single submitter ⚠
p.Pro46Leu Single submitter ⚠
p.Pro475Leu Single submitter ⚠
p.Pro500Thr Single submitter ⚠
p.Pro541Ser Single submitter ⚠
p.Pro570Thr Single submitter ⚠
p.Pro587Leu Single submitter ⚠
p.Pro614Ser Single submitter ⚠
p.Pro709Ala Single submitter ⚠
p.Pro709Thr Single submitter ⚠
p.Pro73Ala Single submitter ⚠
p.Pro743Ser Single submitter ⚠
p.Pro755Leu Single submitter ⚠
p.Pro790Leu Single submitter ⚠
p.Pro83Ser Single submitter ⚠
p.Ser1068Asn Single submitter ⚠
p.Ser107Leu Single submitter ⚠
p.Ser10Ile Single submitter ⚠
p.Ser117Gly Single submitter ⚠
p.Ser169Pro Single submitter ⚠
p.Ser252Thr Single submitter ⚠
p.Ser331Arg Single submitter ⚠
p.Ser357Gly Single submitter ⚠
p.Ser379Tyr Single submitter ⚠
p.Ser404Asn Single submitter ⚠
p.Ser449Pro Single submitter ⚠
p.Ser508Arg Single submitter ⚠
p.Ser531Cys Single submitter ⚠
p.Ser607Arg Single submitter ⚠
p.Ser607Gly Single submitter ⚠
p.Ser622Thr Single submitter ⚠
p.Ser673Leu Single submitter
p.Ser673Thr Single submitter ⚠
p.Ser786Asn Single submitter ⚠
p.Ser832Ile Single submitter ⚠
p.Ser836Leu Single submitter
p.Ser882Asn Single submitter ⚠
p.Ser907Arg Single submitter ⚠
p.Ser954Thr Single submitter ⚠
p.Thr1046Ile Single submitter ⚠
p.Thr12Asn Single submitter ⚠
p.Thr364Ile Single submitter ⚠
p.Thr415Ala Single submitter ⚠
p.Thr415Ile Single submitter ⚠
p.Thr4Ala Single submitter ⚠
p.Thr600Ser Single submitter ⚠
p.Thr986Met Single submitter ⚠
p.Tyr488Cys Single submitter ⚠
p.Tyr501Cys Single submitter ⚠
p.Tyr624Cys Single submitter ⚠
p.Val1026Met Single submitter ⚠
p.Val128Phe Single submitter ⚠
p.Val344Ala Single submitter ⚠
p.Val65Met Single submitter ⚠
p.Val798Ile Single submitter ⚠
p.Val883Met Single submitter ⚠
p.Val964Met Single submitter ⚠