DENND4C — 277 ClinVar variants

All ClinVar germline DENND4C variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 256 flagged for review →

9 Likely benign · 268 Uncertain significance

Full DENND4C gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 256

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors lean, ClinVar uncertain 215

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification. · showing the 150 best-reviewed of 215

Predictors split 41

The independent predictors disagree with each other — read with care.

All DENND4C variants

Likely benign 9

p.Ala595Val Single submitter
p.Arg1306Gly Single submitter
p.Arg889His Single submitter
p.Ile1009Val Single submitter
p.Lys740Asn Single submitter
p.Met1163Val Single submitter
p.Ser1113Leu Single submitter
p.Val1427= Single submitter
p.Val806= Single submitter

Uncertain significance 268

c.5160+1G>A Single submitter
p.Ala1028Glu Single submitter ⚠
p.Ala1144Ser Single submitter ⚠
p.Ala1257Val Single submitter ⚠
p.Ala1282Thr Single submitter
p.Ala1348Val Single submitter ⚠
p.Ala1533Thr Single submitter ⚠
p.Ala1533Val Single submitter ⚠
p.Ala1955Val Single submitter ⚠
p.Ala406Ser Single submitter ⚠
p.Ala437Ser Single submitter ⚠
p.Ala592Ser Single submitter ⚠
p.Ala760Val Single submitter ⚠
p.Ala892Gly Single submitter ⚠
p.Arg1173Ser Single submitter ⚠
p.Arg1218Gly Single submitter ⚠
p.Arg1243Trp Single submitter
p.Arg1279His Single submitter
p.Arg1358Cys Single submitter ⚠
p.Arg1366Gln Single submitter ⚠
p.Arg1371His Single submitter ⚠
p.Arg1380His Single submitter ⚠
p.Arg1726Lys Single submitter ⚠
p.Arg1743Cys Single submitter
p.Arg1743His Single submitter ⚠
p.Arg1950Ser Single submitter ⚠
p.Arg281Trp Single submitter ⚠
p.Arg610His Single submitter ⚠
p.Arg627His Single submitter ⚠
p.Arg721Ser Single submitter ⚠
p.Arg990Gly Single submitter ⚠
p.Asn1443Asp Single submitter ⚠
p.Asn1479His Single submitter ⚠
p.Asn1765Ser Single submitter ⚠
p.Asn1825Ser Single submitter ⚠
p.Asn1878Ser Single submitter ⚠
p.Asn1918Ser Single submitter ⚠
p.Asn308Ser Single submitter ⚠
p.Asn392Ser Single submitter ⚠
p.Asn492Thr Single submitter ⚠
p.Asp1005Val Single submitter ⚠
p.Asp1080Gly Single submitter ⚠
p.Asp1245Gly Single submitter ⚠
p.Asp1270Asn Single submitter ⚠
p.Asp1636Tyr Single submitter ⚠
p.Asp1721Asn Single submitter ⚠
p.Asp374Val Single submitter ⚠
p.Asp479Glu Single submitter ⚠
p.Asp483Gly Single submitter ⚠
p.Asp488Glu Single submitter ⚠
p.Asp498Gly Single submitter ⚠
p.Asp665Glu Single submitter ⚠
p.Asp698Asn Single submitter ⚠
p.Asp978Gly Single submitter ⚠
p.Cys243Gly Single submitter ⚠
p.Gln1543His Single submitter ⚠
p.Gln1855Glu Single submitter ⚠
p.Gln1866His Single submitter ⚠
p.Gln274Arg Single submitter ⚠
p.Glu1307Val Single submitter ⚠
p.Glu1341Gly Single submitter ⚠
p.Glu1343Gly Single submitter ⚠
p.Glu1647Lys Single submitter ⚠
p.Glu1657Lys Single submitter ⚠
p.Glu1853Lys Single submitter ⚠
p.Glu1853Val Single submitter ⚠
p.Glu1947Lys Single submitter ⚠
p.Glu536Ala Single submitter ⚠
p.Glu564Gln Single submitter ⚠
p.Glu564Gly Single submitter ⚠
p.Gly1451Asp Single submitter ⚠
p.Gly1649Ala Single submitter ⚠
p.Gly1754Ser Single submitter
p.Gly1887Ala Single submitter ⚠
p.Gly401Asp Single submitter ⚠
p.Gly401Val Single submitter ⚠
p.Gly962Asp Single submitter ⚠
p.Gly969Arg Single submitter ⚠
p.Gly969Glu Single submitter ⚠
p.His1088Arg Single submitter ⚠
p.His1305Asn Single submitter ⚠
p.His1320Arg Single submitter ⚠
p.His1368Asp Single submitter ⚠
p.His1495Arg Single submitter ⚠
p.His1495Tyr Single submitter ⚠
p.His1620Arg Single submitter ⚠
p.His1705Arg Single submitter ⚠
p.His1870Arg Single submitter ⚠
p.His318Arg Single submitter ⚠
p.His351Tyr Single submitter ⚠
p.His685Pro Single submitter ⚠
p.Ile1120Val Single submitter ⚠
p.Ile1456Val Single submitter ⚠
p.Ile1556Val Single submitter ⚠
p.Ile1644Val Single submitter ⚠
p.Ile1707Ser Single submitter ⚠
p.Ile1764Val Single submitter ⚠
p.Ile1769Val Single submitter ⚠
p.Ile1770Thr Single submitter ⚠
p.Ile1824Thr Single submitter ⚠
p.Ile1864Val Single submitter ⚠
p.Ile1931Val Single submitter ⚠
p.Ile241Val Single submitter ⚠
p.Ile467Val Single submitter ⚠
p.Ile487Val Single submitter ⚠
p.Ile649Met Single submitter ⚠
p.Ile753Leu Single submitter ⚠
p.Ile753Met Single submitter ⚠
p.Ile753Thr Single submitter ⚠
p.Ile910Thr Single submitter ⚠
p.Ile975Thr Single submitter ⚠
p.Leu1220Met Single submitter ⚠
p.Leu1220Ser Single submitter ⚠
p.Leu1378Val Single submitter ⚠
p.Leu1394Phe Single submitter ⚠
p.Leu1397Val Single submitter ⚠
p.Leu1470Phe Single submitter ⚠
p.Leu1613Ser Single submitter ⚠
p.Leu1860Ser Single submitter ⚠
p.Leu419Val Single submitter
p.Leu605Ser Single submitter ⚠
p.Leu618Arg Single submitter ⚠
p.Leu652Met Single submitter ⚠
p.Leu702Arg Single submitter ⚠
p.Leu727Val Single submitter ⚠
p.Leu774Gln Single submitter ⚠
p.Leu832Ile Single submitter ⚠
p.Leu880Ser Single submitter ⚠
p.Lys1012Glu Single submitter ⚠
p.Lys1127Arg Single submitter ⚠
p.Lys1137Glu Single submitter ⚠
p.Lys1353Thr Single submitter ⚠
p.Lys1621Glu Single submitter ⚠
p.Lys305Ile Single submitter ⚠
p.Lys501Asn Single submitter ⚠
p.Lys506Met Single submitter ⚠
p.Lys514Arg Single submitter ⚠
p.Lys700Asn Single submitter ⚠
p.Lys709Arg Single submitter ⚠
p.Lys726Glu Single submitter ⚠
p.Lys747Arg Single submitter ⚠
p.Lys772Glu Single submitter ⚠
p.Lys809Thr Single submitter
p.Lys899Glu Single submitter ⚠
p.Met1121Val Single submitter ⚠
p.Met1314Val Single submitter ⚠
p.Met1507Val Single submitter ⚠
p.Met1534Val Single submitter ⚠
p.Met1668Leu Single submitter ⚠
p.Met330Arg Single submitter ⚠
p.Met542Leu Single submitter ⚠
p.Met542Thr Single submitter ⚠
p.Met560Ile Single submitter ⚠
p.Met560Val Single submitter ⚠
p.Met745Val Single submitter ⚠
p.Met827Thr Single submitter ⚠
p.Phe1041Val Single submitter ⚠
p.Phe1089Ser Single submitter ⚠
p.Phe1096Ser Single submitter ⚠
p.Phe1503Leu Single submitter ⚠
p.Phe1595Leu Single submitter ⚠
p.Phe1634Leu Single submitter ⚠
p.Phe1841Cys Single submitter ⚠
p.Phe1916Leu Single submitter ⚠
p.Phe844Ser Single submitter ⚠
p.Phe844Tyr Single submitter ⚠
p.Pro1016Thr Single submitter ⚠
p.Pro1090His Single submitter ⚠
p.Pro1190Ser Single submitter ⚠
p.Pro1294Leu Single submitter
p.Pro1364Leu Single submitter ⚠
p.Pro1629Ser Single submitter ⚠
p.Pro1703Leu Single submitter ⚠
p.Pro1730Ala Single submitter ⚠
p.Pro1730Ser Single submitter ⚠
p.Pro1730Thr Single submitter ⚠
p.Pro1735Ala Single submitter ⚠
p.Pro1739Leu Single submitter ⚠
p.Pro1768Ser Single submitter ⚠
p.Pro1942Ala Single submitter
p.Pro1942Leu Single submitter ⚠
p.Pro251Leu Single submitter ⚠
p.Pro297His Single submitter ⚠
p.Pro364Leu Single submitter ⚠
p.Pro512Leu Single submitter
p.Pro525His Single submitter ⚠
p.Pro722Leu Single submitter ⚠
p.Pro787Leu Single submitter ⚠
p.Pro869Leu Single submitter ⚠
p.Pro897Leu Single submitter ⚠
p.Ser1017Gly Single submitter ⚠
p.Ser1048Arg Single submitter ⚠
p.Ser1049Asn Single submitter ⚠
p.Ser1139Tyr Single submitter ⚠
p.Ser1148Asn Single submitter ⚠
p.Ser1212Ile Single submitter ⚠
p.Ser1274Phe Single submitter ⚠
p.Ser1299Tyr Single submitter ⚠
p.Ser1301Arg Single submitter ⚠
p.Ser1342Arg Single submitter ⚠
p.Ser1350Pro Single submitter ⚠
p.Ser1374Cys Single submitter ⚠
p.Ser1386Leu Single submitter ⚠
p.Ser1434Gly Single submitter ⚠
p.Ser1481Arg Single submitter ⚠
p.Ser1602Phe Single submitter ⚠
p.Ser1655Arg Single submitter ⚠
p.Ser1748Cys Single submitter ⚠
p.Ser1785Asn Single submitter ⚠
p.Ser1848Phe Single submitter ⚠
p.Ser1867Gly Single submitter ⚠
p.Ser1881Leu Single submitter ⚠
p.Ser1893Asn Single submitter ⚠
p.Ser1943Arg Single submitter ⚠
p.Ser1945Gly Single submitter ⚠
p.Ser1945Thr Single submitter ⚠
p.Ser304Phe Single submitter ⚠
p.Ser336Cys Single submitter ⚠
p.Ser338Phe Single submitter ⚠
p.Ser422Ala Single submitter ⚠
p.Ser422Thr Single submitter ⚠
p.Ser572Cys Single submitter ⚠
p.Ser876Arg Single submitter ⚠
p.Thr1050Ser Single submitter ⚠
p.Thr1073Ala Single submitter ⚠
p.Thr1167Ile Single submitter ⚠
p.Thr1198Ser Single submitter ⚠
p.Thr1204Ala Single submitter ⚠
p.Thr1373Ile Single submitter ⚠
p.Thr1373Pro Single submitter ⚠
p.Thr1480Pro Single submitter ⚠
p.Thr1561Ser Single submitter ⚠
p.Thr1857Lys Single submitter ⚠
p.Thr309Ile Single submitter ⚠
p.Thr734Ile Single submitter ⚠
p.Thr739Ile Single submitter ⚠
p.Thr755Arg Single submitter ⚠
p.Trp1029Cys Single submitter ⚠
p.Trp1821Arg Single submitter ⚠
p.Trp244Cys Single submitter ⚠
p.Trp833Cys Single submitter ⚠
p.Tyr1433Cys Single submitter ⚠
p.Tyr1446His Single submitter ⚠
p.Tyr1529Phe Single submitter ⚠
p.Tyr1895Cys Single submitter ⚠
p.Tyr495His Single submitter ⚠
p.Tyr612Phe Single submitter ⚠
p.Tyr710Cys Single submitter ⚠
p.Tyr764Phe Single submitter ⚠
p.Tyr789Cys Single submitter ⚠
p.Tyr804Ser Single submitter ⚠
p.Val1010Leu Single submitter ⚠
p.Val1240Met Single submitter ⚠
p.Val1349Ala Single submitter ⚠
p.Val1719Ile Single submitter ⚠
p.Val1757Met Single submitter
p.Val1775Ile Single submitter ⚠
p.Val1815Gly Single submitter ⚠
p.Val1815Leu Single submitter ⚠
p.Val431Ile Single submitter ⚠
p.Val435Ile Single submitter ⚠
p.Val468Ala Single submitter ⚠
p.Val797Gly Single submitter ⚠
p.Val826Leu Single submitter ⚠
p.Val865Asp Single submitter ⚠
p.Val887Gly Single submitter ⚠
p.Val888Leu Single submitter ⚠
p.Val907Phe Single submitter ⚠