DERA — 45 ClinVar variants
All ClinVar germline DERA variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 43 flagged for review →
2 Likely benign · 43 Uncertain significance
Full DERA gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 43
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 18
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- DERA p.Ala115Ser Uncertain significance Single submitter
- DERA p.Ala228Gly Uncertain significance Single submitter
- DERA p.Ala262Val Uncertain significance Single submitter
- DERA p.Arg176Cys Uncertain significance Single submitter
- DERA p.Arg287Pro Uncertain significance Single submitter
- DERA p.Arg80Trp Uncertain significance Single submitter
- DERA p.Asn119Ser Uncertain significance Single submitter
- DERA p.Cys107Tyr Uncertain significance Single submitter
- DERA p.Gly128Arg Uncertain significance Single submitter
- DERA p.His303Arg Uncertain significance Single submitter
- DERA p.Ile208Val Uncertain significance Single submitter
- DERA p.Leu315Val Uncertain significance Single submitter
- DERA p.Met317Val Uncertain significance Single submitter
- DERA p.Pro23Ser Uncertain significance Single submitter
- DERA p.Ser291Asn Uncertain significance Single submitter
- DERA p.Thr193Arg Uncertain significance Single submitter
- DERA p.Trp42Arg Uncertain significance Single submitter
- DERA p.Trp42Cys Uncertain significance Single submitter
Predictors split 25
The independent predictors disagree with each other — read with care.
- DERA p.Ala131Thr Uncertain significance Single submitter
- DERA p.Ala29Val Uncertain significance Single submitter
- DERA p.Arg105Gly Uncertain significance Single submitter
- DERA p.Arg105Trp Uncertain significance Single submitter
- DERA p.Arg179Cys Uncertain significance Single submitter
- DERA p.Arg260Cys Uncertain significance Single submitter
- DERA p.Arg260His Uncertain significance Single submitter
- DERA p.Arg28Cys Uncertain significance Single submitter
- DERA p.Arg35Cys Uncertain significance Single submitter
- DERA p.Arg35Leu Uncertain significance Single submitter
- DERA p.Arg80Gly Uncertain significance Single submitter
- DERA p.Asn67Ser Uncertain significance Single submitter
- DERA p.Gln300Glu Uncertain significance Single submitter
- DERA p.Gly183Arg Uncertain significance Single submitter
- DERA p.His186Tyr Uncertain significance Single submitter
- DERA p.Leu187Phe Uncertain significance Single submitter
- DERA p.Leu71Val Uncertain significance Single submitter
- DERA p.Lys204Glu Uncertain significance Single submitter
- DERA p.Met210Val Uncertain significance Single submitter
- DERA p.Phe244Leu Uncertain significance Single submitter
- DERA p.Pro23Leu Uncertain significance Single submitter
- DERA p.Thr225Arg Uncertain significance Single submitter
- DERA p.Thr306Asn Uncertain significance Single submitter
- DERA p.Thr306Ile Uncertain significance Single submitter
- DERA p.Val156Ala Uncertain significance Single submitter
All DERA variants
Likely benign 2
- p.Gln19= Single submitter
- p.Ile251Val Single submitter
Uncertain significance 43
- p.Ala115Ser Single submitter ⚠
- p.Ala131Thr Single submitter ⚠
- p.Ala228Gly Single submitter ⚠
- p.Ala262Val Single submitter ⚠
- p.Ala29Val Single submitter ⚠
- p.Arg105Gly Single submitter ⚠
- p.Arg105Trp Single submitter ⚠
- p.Arg176Cys Single submitter ⚠
- p.Arg179Cys Single submitter ⚠
- p.Arg260Cys Single submitter ⚠
- p.Arg260His Single submitter ⚠
- p.Arg287Pro Single submitter ⚠
- p.Arg28Cys Single submitter ⚠
- p.Arg35Cys Single submitter ⚠
- p.Arg35Leu Single submitter ⚠
- p.Arg80Gly Single submitter ⚠
- p.Arg80Trp Single submitter ⚠
- p.Asn119Ser Single submitter ⚠
- p.Asn67Ser Single submitter ⚠
- p.Cys107Tyr Single submitter ⚠
- p.Gln300Glu Single submitter ⚠
- p.Gly128Arg Single submitter ⚠
- p.Gly183Arg Single submitter ⚠
- p.His186Tyr Single submitter ⚠
- p.His303Arg Single submitter ⚠
- p.Ile208Val Single submitter ⚠
- p.Leu187Phe Single submitter ⚠
- p.Leu315Val Single submitter ⚠
- p.Leu71Val Single submitter ⚠
- p.Lys204Glu Single submitter ⚠
- p.Met210Val Single submitter ⚠
- p.Met317Val Single submitter ⚠
- p.Phe244Leu Single submitter ⚠
- p.Pro23Leu Single submitter ⚠
- p.Pro23Ser Single submitter ⚠
- p.Ser291Asn Single submitter ⚠
- p.Thr193Arg Single submitter ⚠
- p.Thr225Arg Single submitter ⚠
- p.Thr306Asn Single submitter ⚠
- p.Thr306Ile Single submitter ⚠
- p.Trp42Arg Single submitter ⚠
- p.Trp42Cys Single submitter ⚠
- p.Val156Ala Single submitter ⚠