DHRS7 — 53 ClinVar variants
All ClinVar germline DHRS7 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 53 flagged for review →
53 Uncertain significance
Full DHRS7 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 53
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 20
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- DHRS7 p.Arg211Gln Uncertain significance Single submitter
- DHRS7 p.Arg268His Uncertain significance Single submitter
- DHRS7 p.Arg271Gln Uncertain significance Single submitter
- DHRS7 p.Arg93Ser Uncertain significance Single submitter
- DHRS7 p.Asn257Asp Uncertain significance Single submitter
- DHRS7 p.Gln182Glu Uncertain significance Single submitter
- DHRS7 p.Gly183Ala Uncertain significance Single submitter
- DHRS7 p.Gly41Glu Uncertain significance Single submitter
- DHRS7 p.His338Tyr Uncertain significance Single submitter
- DHRS7 p.Ile185Thr Uncertain significance Single submitter
- DHRS7 p.Ile254Thr Uncertain significance Single submitter
- DHRS7 p.Leu77Pro Uncertain significance Single submitter
- DHRS7 p.Lys282Asn Uncertain significance Single submitter
- DHRS7 p.Lys321Arg Uncertain significance Single submitter
- DHRS7 p.Met177Thr Uncertain significance Single submitter
- DHRS7 p.Met51Thr Uncertain significance Single submitter
- DHRS7 p.Phe214Leu Uncertain significance Single submitter
- DHRS7 p.Ser196Tyr Uncertain significance Single submitter
- DHRS7 p.Ser59Leu Uncertain significance Single submitter
- DHRS7 p.Tyr224His Uncertain significance Single submitter
Predictors split 33
The independent predictors disagree with each other — read with care.
- DHRS7 p.Arg211Trp Uncertain significance Multiple submitters
- DHRS7 p.Ala124Gly Uncertain significance Single submitter
- DHRS7 p.Ala124Val Uncertain significance Single submitter
- DHRS7 p.Ala305Val Uncertain significance Single submitter
- DHRS7 p.Arg144His Uncertain significance Single submitter
- DHRS7 p.Arg268Cys Uncertain significance Single submitter
- DHRS7 p.Arg271Trp Uncertain significance Single submitter
- DHRS7 p.Asn138Ser Uncertain significance Single submitter
- DHRS7 p.Asn162Ser Uncertain significance Single submitter
- DHRS7 p.Asp111Asn Uncertain significance Single submitter
- DHRS7 p.Asp133Asn Uncertain significance Single submitter
- DHRS7 p.Cys172Trp Uncertain significance Single submitter
- DHRS7 p.Cys233Phe Uncertain significance Single submitter
- DHRS7 p.Glu119Gly Uncertain significance Single submitter
- DHRS7 p.Glu179Lys Uncertain significance Single submitter
- DHRS7 p.Glu249Ala Uncertain significance Single submitter
- DHRS7 p.Glu38Gln Uncertain significance Single submitter
- DHRS7 p.Glu65Gln Uncertain significance Single submitter
- DHRS7 p.His118Tyr Uncertain significance Single submitter
- DHRS7 p.His176Asn Uncertain significance Single submitter
- DHRS7 p.Ile227Val Uncertain significance Single submitter
- DHRS7 p.Leu16Ile Uncertain significance Single submitter
- DHRS7 p.Leu217Phe Uncertain significance Single submitter
- DHRS7 p.Leu246Pro Uncertain significance Single submitter
- DHRS7 p.Met277Thr Uncertain significance Single submitter
- DHRS7 p.Pro109Leu Uncertain significance Single submitter
- DHRS7 p.Pro44Leu Uncertain significance Single submitter
- DHRS7 p.Ser168Thr Uncertain significance Single submitter
- DHRS7 p.Ser245Pro Uncertain significance Single submitter
- DHRS7 p.Ser276Ile Uncertain significance Single submitter
- DHRS7 p.Thr166Met Uncertain significance Single submitter
- DHRS7 p.Val167Leu Uncertain significance Single submitter
- DHRS7 p.Val173Ile Uncertain significance Single submitter
All DHRS7 variants
Uncertain significance 53
- p.Arg211Trp Multiple submitters ⚠
- p.Ala124Gly Single submitter ⚠
- p.Ala124Val Single submitter ⚠
- p.Ala305Val Single submitter ⚠
- p.Arg144His Single submitter ⚠
- p.Arg211Gln Single submitter ⚠
- p.Arg268Cys Single submitter ⚠
- p.Arg268His Single submitter ⚠
- p.Arg271Gln Single submitter ⚠
- p.Arg271Trp Single submitter ⚠
- p.Arg93Ser Single submitter ⚠
- p.Asn138Ser Single submitter ⚠
- p.Asn162Ser Single submitter ⚠
- p.Asn257Asp Single submitter ⚠
- p.Asp111Asn Single submitter ⚠
- p.Asp133Asn Single submitter ⚠
- p.Cys172Trp Single submitter ⚠
- p.Cys233Phe Single submitter ⚠
- p.Gln182Glu Single submitter ⚠
- p.Glu119Gly Single submitter ⚠
- p.Glu179Lys Single submitter ⚠
- p.Glu249Ala Single submitter ⚠
- p.Glu38Gln Single submitter ⚠
- p.Glu65Gln Single submitter ⚠
- p.Gly183Ala Single submitter ⚠
- p.Gly41Glu Single submitter ⚠
- p.His118Tyr Single submitter ⚠
- p.His176Asn Single submitter ⚠
- p.His338Tyr Single submitter ⚠
- p.Ile185Thr Single submitter ⚠
- p.Ile227Val Single submitter ⚠
- p.Ile254Thr Single submitter ⚠
- p.Leu16Ile Single submitter ⚠
- p.Leu217Phe Single submitter ⚠
- p.Leu246Pro Single submitter ⚠
- p.Leu77Pro Single submitter ⚠
- p.Lys282Asn Single submitter ⚠
- p.Lys321Arg Single submitter ⚠
- p.Met177Thr Single submitter ⚠
- p.Met277Thr Single submitter ⚠
- p.Met51Thr Single submitter ⚠
- p.Phe214Leu Single submitter ⚠
- p.Pro109Leu Single submitter ⚠
- p.Pro44Leu Single submitter ⚠
- p.Ser168Thr Single submitter ⚠
- p.Ser196Tyr Single submitter ⚠
- p.Ser245Pro Single submitter ⚠
- p.Ser276Ile Single submitter ⚠
- p.Ser59Leu Single submitter ⚠
- p.Thr166Met Single submitter ⚠
- p.Tyr224His Single submitter ⚠
- p.Val167Leu Single submitter ⚠
- p.Val173Ile Single submitter ⚠