DHRS7B — 51 ClinVar variants
All ClinVar germline DHRS7B variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 48 flagged for review →
4 Likely benign · 47 Uncertain significance
Full DHRS7B gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 48
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 25
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- DHRS7B p.Ala213Thr Uncertain significance Single submitter
- DHRS7B p.Arg148Cys Uncertain significance Single submitter
- DHRS7B p.Arg204Gln Uncertain significance Single submitter
- DHRS7B p.Arg39Gln Uncertain significance Single submitter
- DHRS7B p.Asp137Glu Uncertain significance Single submitter
- DHRS7B p.Asp159His Uncertain significance Single submitter
- DHRS7B p.Cys220Tyr Uncertain significance Single submitter
- DHRS7B p.Cys31Phe Uncertain significance Single submitter
- DHRS7B p.Gln105Arg Uncertain significance Single submitter
- DHRS7B p.Glu231Lys Uncertain significance Single submitter
- DHRS7B p.Gly253Arg Uncertain significance Single submitter
- DHRS7B p.Gly86Ser Uncertain significance Single submitter
- DHRS7B p.His241Gln Uncertain significance Single submitter
- DHRS7B p.Ile182Ser Uncertain significance Single submitter
- DHRS7B p.Ile19Val Uncertain significance Single submitter
- DHRS7B p.Ile93Val Uncertain significance Single submitter
- DHRS7B p.Leu139Phe Uncertain significance Single submitter
- DHRS7B p.Leu37Val Uncertain significance Single submitter
- DHRS7B p.Leu40Val Uncertain significance Single submitter
- DHRS7B p.Phe203Tyr Uncertain significance Single submitter
- DHRS7B p.Ser236Arg Uncertain significance Single submitter
- DHRS7B p.Thr242Ser Uncertain significance Single submitter
- DHRS7B p.Thr6Ser Uncertain significance Single submitter
- DHRS7B p.Tyr110Cys Uncertain significance Single submitter
- DHRS7B p.Val270Leu Uncertain significance Single submitter
Predictors split 23
The independent predictors disagree with each other — read with care.
- DHRS7B p.Ala208Gly Uncertain significance Single submitter
- DHRS7B p.Ala213Ser Uncertain significance Single submitter
- DHRS7B p.Ala251Thr Uncertain significance Single submitter
- DHRS7B p.Ala251Val Uncertain significance Single submitter
- DHRS7B p.Ala273Gly Uncertain significance Single submitter
- DHRS7B p.Ala75Val Uncertain significance Single submitter
- DHRS7B p.Arg222Cys Uncertain significance Single submitter
- DHRS7B p.Arg45Cys Uncertain significance Single submitter
- DHRS7B p.Asp252Gly Uncertain significance Single submitter
- DHRS7B p.Gln42His Uncertain significance Single submitter
- DHRS7B p.Glu319Ala Uncertain significance Single submitter
- DHRS7B p.Gly238Ser Uncertain significance Single submitter
- DHRS7B p.Ile192Met Uncertain significance Single submitter
- DHRS7B p.Ile249Thr Uncertain significance Single submitter
- DHRS7B p.Leu244Phe Uncertain significance Single submitter
- DHRS7B p.Pro170Ser Uncertain significance Single submitter
- DHRS7B p.Pro26Thr Uncertain significance Single submitter
- DHRS7B p.Pro305Ala Uncertain significance Single submitter
- DHRS7B p.Thr174Met Uncertain significance Single submitter
- DHRS7B p.Tyr135Cys Uncertain significance Single submitter
- DHRS7B p.Tyr299His Uncertain significance Single submitter
- DHRS7B p.Val272Met Uncertain significance Single submitter
- DHRS7B p.Val298Ile Likely benign Single submitter
All DHRS7B variants
Likely benign 4
- p.Arg320Gln Single submitter
- p.Phe35= Single submitter
- p.Pro11Leu Single submitter
- p.Val298Ile Single submitter ⚠
Uncertain significance 47
- p.Ala208Gly Single submitter ⚠
- p.Ala213Ser Single submitter ⚠
- p.Ala213Thr Single submitter ⚠
- p.Ala251Thr Single submitter ⚠
- p.Ala251Val Single submitter ⚠
- p.Ala273Gly Single submitter ⚠
- p.Ala75Val Single submitter ⚠
- p.Arg148Cys Single submitter ⚠
- p.Arg204Gln Single submitter ⚠
- p.Arg222Cys Single submitter ⚠
- p.Arg39Gln Single submitter ⚠
- p.Arg45Cys Single submitter ⚠
- p.Asp137Glu Single submitter ⚠
- p.Asp159His Single submitter ⚠
- p.Asp252Gly Single submitter ⚠
- p.Cys220Tyr Single submitter ⚠
- p.Cys31Phe Single submitter ⚠
- p.Gln105Arg Single submitter ⚠
- p.Gln42His Single submitter ⚠
- p.Glu231Lys Single submitter ⚠
- p.Glu319Ala Single submitter ⚠
- p.Gly238Ser Single submitter ⚠
- p.Gly253Arg Single submitter ⚠
- p.Gly86Ser Single submitter ⚠
- p.His241Gln Single submitter ⚠
- p.Ile182Ser Single submitter ⚠
- p.Ile192Met Single submitter ⚠
- p.Ile19Val Single submitter ⚠
- p.Ile249Thr Single submitter ⚠
- p.Ile93Val Single submitter ⚠
- p.Leu139Phe Single submitter ⚠
- p.Leu244Phe Single submitter ⚠
- p.Leu37Val Single submitter ⚠
- p.Leu40Val Single submitter ⚠
- p.Phe203Tyr Single submitter ⚠
- p.Pro170Ser Single submitter ⚠
- p.Pro26Thr Single submitter ⚠
- p.Pro305Ala Single submitter ⚠
- p.Ser236Arg Single submitter ⚠
- p.Thr174Met Single submitter ⚠
- p.Thr242Ser Single submitter ⚠
- p.Thr6Ser Single submitter ⚠
- p.Tyr110Cys Single submitter ⚠
- p.Tyr135Cys Single submitter ⚠
- p.Tyr299His Single submitter ⚠
- p.Val270Leu Single submitter ⚠
- p.Val272Met Single submitter ⚠