DHRS9 — 42 ClinVar variants
All ClinVar germline DHRS9 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 36 flagged for review →
1 Likely benign · 41 Uncertain significance
Full DHRS9 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 36
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 28
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- DHRS9 p.Ala196Thr Uncertain significance Single submitter
- DHRS9 p.Ala214Val Uncertain significance Single submitter
- DHRS9 p.Ala225Thr Uncertain significance Single submitter
- DHRS9 p.Ala283Thr Uncertain significance Single submitter
- DHRS9 p.Ala46Val Uncertain significance Single submitter
- DHRS9 p.Ala59Pro Uncertain significance Single submitter
- DHRS9 p.Ala68Pro Uncertain significance Single submitter
- DHRS9 p.Arg192Gln Uncertain significance Single submitter
- DHRS9 p.Asp83Glu Uncertain significance Single submitter
- DHRS9 p.Glu135Lys Uncertain significance Single submitter
- DHRS9 p.Gly284Arg Uncertain significance Single submitter
- DHRS9 p.Ile160Asn Uncertain significance Single submitter
- DHRS9 p.Ile204Val Uncertain significance Single submitter
- DHRS9 p.Leu138Pro Uncertain significance Single submitter
- DHRS9 p.Leu224His Uncertain significance Single submitter
- DHRS9 p.Leu224Phe Uncertain significance Single submitter
- DHRS9 p.Leu250Val Uncertain significance Single submitter
- DHRS9 p.Leu275Phe Uncertain significance Single submitter
- DHRS9 p.Leu8Phe Uncertain significance Single submitter
- DHRS9 p.Lys21Asn Uncertain significance Single submitter
- DHRS9 p.Lys288Arg Uncertain significance Single submitter
- DHRS9 p.Phe186Leu Uncertain significance Single submitter
- DHRS9 p.Pro121Ser Uncertain significance Single submitter
- DHRS9 p.Ser255Phe Uncertain significance Single submitter
- DHRS9 p.Ser74Leu Uncertain significance Single submitter
- DHRS9 p.Trp291Arg Uncertain significance Single submitter
- DHRS9 p.Val118Met Uncertain significance Single submitter
- DHRS9 p.Val201Ile Uncertain significance Single submitter
Predictors split 8
The independent predictors disagree with each other — read with care.
- DHRS9 p.Arg168Cys Uncertain significance Single submitter
- DHRS9 p.Gly117Val Uncertain significance Single submitter
- DHRS9 p.Gly185Val Uncertain significance Single submitter
- DHRS9 p.Ile134Thr Uncertain significance Single submitter
- DHRS9 p.Ile234Phe Uncertain significance Single submitter
- DHRS9 p.Pro293Leu Uncertain significance Single submitter
- DHRS9 p.Thr273Arg Uncertain significance Single submitter
- DHRS9 p.Val101Ala Uncertain significance Single submitter
All DHRS9 variants
Likely benign 1
- p.Ile171Phe Single submitter
Uncertain significance 41
- p.Ala196Thr Single submitter ⚠
- p.Ala214Val Single submitter ⚠
- p.Ala225Thr Single submitter ⚠
- p.Ala283Thr Single submitter ⚠
- p.Ala46Val Single submitter ⚠
- p.Ala59Pro Single submitter ⚠
- p.Ala68Pro Single submitter ⚠
- p.Arg168Cys Single submitter ⚠
- p.Arg192Gln Single submitter ⚠
- p.Arg192Trp Single submitter
- p.Asp83Glu Single submitter ⚠
- p.Glu135Lys Single submitter ⚠
- p.Gly117Val Single submitter ⚠
- p.Gly185Val Single submitter ⚠
- p.Gly284Arg Single submitter ⚠
- p.His280Asn Single submitter
- p.Ile134Thr Single submitter ⚠
- p.Ile160Asn Single submitter ⚠
- p.Ile204Val Single submitter ⚠
- p.Ile234Phe Single submitter ⚠
- p.Leu138Pro Single submitter ⚠
- p.Leu224His Single submitter ⚠
- p.Leu224Phe Single submitter ⚠
- p.Leu250Val Single submitter ⚠
- p.Leu275Phe Single submitter ⚠
- p.Leu8Phe Single submitter ⚠
- p.Lys21Asn Single submitter ⚠
- p.Lys235Glu Single submitter
- p.Lys288Arg Single submitter ⚠
- p.Phe186Leu Single submitter ⚠
- p.Phe33Ile Single submitter
- p.Pro121Ser Single submitter ⚠
- p.Pro293Leu Single submitter ⚠
- p.Ser255Phe Single submitter ⚠
- p.Ser274Asn Single submitter
- p.Ser74Leu Single submitter ⚠
- p.Thr273Arg Single submitter ⚠
- p.Trp291Arg Single submitter ⚠
- p.Val101Ala Single submitter ⚠
- p.Val118Met Single submitter ⚠
- p.Val201Ile Single submitter ⚠