DIMT1 — 38 ClinVar variants
All ClinVar germline DIMT1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 36 flagged for review →
1 Likely benign · 37 Uncertain significance
Full DIMT1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 36
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 29
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- DIMT1 p.Ala240Pro Uncertain significance Single submitter
- DIMT1 p.Ala307Thr Uncertain significance Single submitter
- DIMT1 p.Ala307Val Uncertain significance Single submitter
- DIMT1 p.Arg13Ser Uncertain significance Single submitter
- DIMT1 p.Arg19His Uncertain significance Single submitter
- DIMT1 p.Arg20Gln Uncertain significance Single submitter
- DIMT1 p.Arg289Trp Uncertain significance Single submitter
- DIMT1 p.Asn219Asp Uncertain significance Single submitter
- DIMT1 p.Gln18His Uncertain significance Single submitter
- DIMT1 p.Glu203Asp Uncertain significance Single submitter
- DIMT1 p.Gly112Asp Uncertain significance Single submitter
- DIMT1 p.His144Arg Uncertain significance Single submitter
- DIMT1 p.Ile133Leu Uncertain significance Single submitter
- DIMT1 p.Ile218Leu Uncertain significance Single submitter
- DIMT1 p.Ile34Asn Uncertain significance Single submitter
- DIMT1 p.Ile38Val Uncertain significance Single submitter
- DIMT1 p.Ile9Asn Uncertain significance Single submitter
- DIMT1 p.Lys275Arg Uncertain significance Single submitter
- DIMT1 p.Lys275Ile Uncertain significance Single submitter
- DIMT1 p.Lys275Thr Uncertain significance Single submitter
- DIMT1 p.Lys96Arg Uncertain significance Single submitter
- DIMT1 p.Lys96Glu Uncertain significance Single submitter
- DIMT1 p.Met154Ile Uncertain significance Single submitter
- DIMT1 p.Phe147Ile Uncertain significance Single submitter
- DIMT1 p.Pro120Thr Uncertain significance Single submitter
- DIMT1 p.Pro136Leu Uncertain significance Single submitter
- DIMT1 p.Pro198Leu Uncertain significance Single submitter
- DIMT1 p.Val191Leu Uncertain significance Single submitter
- DIMT1 p.Val60Met Uncertain significance Single submitter
Predictors split 7
The independent predictors disagree with each other — read with care.
- DIMT1 p.Arg228Lys Uncertain significance Single submitter
- DIMT1 p.Arg291His Uncertain significance Single submitter
- DIMT1 p.Asp186Gly Uncertain significance Single submitter
- DIMT1 p.Ile44Met Uncertain significance Single submitter
- DIMT1 p.Leu143Pro Uncertain significance Single submitter
- DIMT1 p.Val59Ala Uncertain significance Single submitter
- DIMT1 p.Val59Leu Uncertain significance Single submitter
All DIMT1 variants
Likely benign 1
- p.Thr101= Single submitter
Uncertain significance 37
- p.Ala240Pro Single submitter ⚠
- p.Ala307Thr Single submitter ⚠
- p.Ala307Val Single submitter ⚠
- p.Arg13Ser Single submitter ⚠
- p.Arg184Cys Single submitter
- p.Arg19His Single submitter ⚠
- p.Arg20Gln Single submitter ⚠
- p.Arg228Lys Single submitter ⚠
- p.Arg289Trp Single submitter ⚠
- p.Arg291His Single submitter ⚠
- p.Asn219Asp Single submitter ⚠
- p.Asp186Gly Single submitter ⚠
- p.Gln18His Single submitter ⚠
- p.Glu203Asp Single submitter ⚠
- p.Gly112Asp Single submitter ⚠
- p.His144Arg Single submitter ⚠
- p.Ile133Leu Single submitter ⚠
- p.Ile218Leu Single submitter ⚠
- p.Ile34Asn Single submitter ⚠
- p.Ile38Val Single submitter ⚠
- p.Ile44Met Single submitter ⚠
- p.Ile9Asn Single submitter ⚠
- p.Leu143Pro Single submitter ⚠
- p.Lys275Arg Single submitter ⚠
- p.Lys275Ile Single submitter ⚠
- p.Lys275Thr Single submitter ⚠
- p.Lys96Arg Single submitter ⚠
- p.Lys96Glu Single submitter ⚠
- p.Met154Ile Single submitter ⚠
- p.Phe147Ile Single submitter ⚠
- p.Pro120Thr Single submitter ⚠
- p.Pro136Leu Single submitter ⚠
- p.Pro198Leu Single submitter ⚠
- p.Val191Leu Single submitter ⚠
- p.Val59Ala Single submitter ⚠
- p.Val59Leu Single submitter ⚠
- p.Val60Met Single submitter ⚠