DIPK1A — 48 ClinVar variants
All ClinVar germline DIPK1A variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 48 flagged for review →
48 Uncertain significance
Full DIPK1A gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 48
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 37
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- DIPK1A p.Arg20His Uncertain significance Single submitter
- DIPK1A p.Arg255Ser Uncertain significance Single submitter
- DIPK1A p.Arg25Gln Uncertain significance Single submitter
- DIPK1A p.Arg376Cys Uncertain significance Single submitter
- DIPK1A p.Arg376His Uncertain significance Single submitter
- DIPK1A p.Arg383His Uncertain significance Single submitter
- DIPK1A p.Asn107Ser Uncertain significance Single submitter
- DIPK1A p.Asn172Ser Uncertain significance Single submitter
- DIPK1A p.Asn426Ser Uncertain significance Single submitter
- DIPK1A p.Asp258Gly Uncertain significance Single submitter
- DIPK1A p.Asp304Gly Uncertain significance Single submitter
- DIPK1A p.Gln115His Uncertain significance Single submitter
- DIPK1A p.Gln164His Uncertain significance Single submitter
- DIPK1A p.Gln360Glu Uncertain significance Single submitter
- DIPK1A p.Glu117Gln Uncertain significance Single submitter
- DIPK1A p.Glu129Val Uncertain significance Single submitter
- DIPK1A p.Glu232Asp Uncertain significance Single submitter
- DIPK1A p.Gly238Glu Uncertain significance Single submitter
- DIPK1A p.Ile273Thr Uncertain significance Single submitter
- DIPK1A p.Ile359Thr Uncertain significance Single submitter
- DIPK1A p.Ile410Val Uncertain significance Single submitter
- DIPK1A p.Ile42Val Uncertain significance Single submitter
- DIPK1A p.Ile43Val Uncertain significance Single submitter
- DIPK1A p.Leu236Ile Uncertain significance Single submitter
- DIPK1A p.Lys268Arg Uncertain significance Single submitter
- DIPK1A p.Lys298Arg Uncertain significance Single submitter
- DIPK1A p.Lys415Asn Uncertain significance Single submitter
- DIPK1A p.Met228Thr Uncertain significance Single submitter
- DIPK1A p.Met292Ile Uncertain significance Single submitter
- DIPK1A p.Met292Lys Uncertain significance Single submitter
- DIPK1A p.Met313Val Uncertain significance Single submitter
- DIPK1A p.Pro14Thr Uncertain significance Single submitter
- DIPK1A p.Ser187Pro Uncertain significance Single submitter
- DIPK1A p.Ser240Arg Uncertain significance Single submitter
- DIPK1A p.Ser93Pro Uncertain significance Single submitter
- DIPK1A p.Thr176Met Uncertain significance Single submitter
- DIPK1A p.Val45Met Uncertain significance Single submitter
Predictors split 11
The independent predictors disagree with each other — read with care.
- DIPK1A p.Ala395Val Uncertain significance Single submitter
- DIPK1A p.Arg20Cys Uncertain significance Single submitter
- DIPK1A p.Ile273Met Uncertain significance Single submitter
- DIPK1A p.Ile72Thr Uncertain significance Single submitter
- DIPK1A p.Leu396Val Uncertain significance Single submitter
- DIPK1A p.Lys68Glu Uncertain significance Single submitter
- DIPK1A p.Met152Val Uncertain significance Single submitter
- DIPK1A p.Phe88Leu Uncertain significance Single submitter
- DIPK1A p.Pro361Thr Uncertain significance Single submitter
- DIPK1A p.Ser155Ile Uncertain significance Single submitter
- DIPK1A p.Thr351Ile Uncertain significance Single submitter
All DIPK1A variants
Uncertain significance 48
- p.Ala395Val Single submitter ⚠
- p.Arg20Cys Single submitter ⚠
- p.Arg20His Single submitter ⚠
- p.Arg255Ser Single submitter ⚠
- p.Arg25Gln Single submitter ⚠
- p.Arg376Cys Single submitter ⚠
- p.Arg376His Single submitter ⚠
- p.Arg383His Single submitter ⚠
- p.Asn107Ser Single submitter ⚠
- p.Asn172Ser Single submitter ⚠
- p.Asn426Ser Single submitter ⚠
- p.Asp258Gly Single submitter ⚠
- p.Asp304Gly Single submitter ⚠
- p.Gln115His Single submitter ⚠
- p.Gln164His Single submitter ⚠
- p.Gln360Glu Single submitter ⚠
- p.Glu117Gln Single submitter ⚠
- p.Glu129Val Single submitter ⚠
- p.Glu232Asp Single submitter ⚠
- p.Gly238Glu Single submitter ⚠
- p.Ile273Met Single submitter ⚠
- p.Ile273Thr Single submitter ⚠
- p.Ile359Thr Single submitter ⚠
- p.Ile410Val Single submitter ⚠
- p.Ile42Val Single submitter ⚠
- p.Ile43Val Single submitter ⚠
- p.Ile72Thr Single submitter ⚠
- p.Leu236Ile Single submitter ⚠
- p.Leu396Val Single submitter ⚠
- p.Lys268Arg Single submitter ⚠
- p.Lys298Arg Single submitter ⚠
- p.Lys415Asn Single submitter ⚠
- p.Lys68Glu Single submitter ⚠
- p.Met152Val Single submitter ⚠
- p.Met228Thr Single submitter ⚠
- p.Met292Ile Single submitter ⚠
- p.Met292Lys Single submitter ⚠
- p.Met313Val Single submitter ⚠
- p.Phe88Leu Single submitter ⚠
- p.Pro14Thr Single submitter ⚠
- p.Pro361Thr Single submitter ⚠
- p.Ser155Ile Single submitter ⚠
- p.Ser187Pro Single submitter ⚠
- p.Ser240Arg Single submitter ⚠
- p.Ser93Pro Single submitter ⚠
- p.Thr176Met Single submitter ⚠
- p.Thr351Ile Single submitter ⚠
- p.Val45Met Single submitter ⚠