DIS3L — 154 ClinVar variants
All ClinVar germline DIS3L variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 153 flagged for review →
2 Likely benign · 152 Uncertain significance
Full DIS3L gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 153
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 81
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- DIS3L p.Ala362Val Uncertain significance Single submitter
- DIS3L p.Ala593Val Uncertain significance Single submitter
- DIS3L p.Ala693Thr Uncertain significance Single submitter
- DIS3L p.Arg1026His Uncertain significance Single submitter
- DIS3L p.Arg1026Pro Uncertain significance Single submitter
- DIS3L p.Arg104Gln Uncertain significance Single submitter
- DIS3L p.Arg23Cys Uncertain significance Single submitter
- DIS3L p.Arg391Ser Uncertain significance Single submitter
- DIS3L p.Arg395Leu Uncertain significance Single submitter
- DIS3L p.Arg465Cys Uncertain significance Single submitter
- DIS3L p.Arg465Leu Uncertain significance Single submitter
- DIS3L p.Arg556Ser Uncertain significance Single submitter
- DIS3L p.Arg801Lys Uncertain significance Single submitter
- DIS3L p.Asn119Asp Uncertain significance Single submitter
- DIS3L p.Asn431Ile Uncertain significance Single submitter
- DIS3L p.Asn449Asp Uncertain significance Single submitter
- DIS3L p.Asn449His Uncertain significance Single submitter
- DIS3L p.Asp318Asn Uncertain significance Single submitter
- DIS3L p.Asp634Asn Uncertain significance Single submitter
- DIS3L p.Asp916Glu Uncertain significance Single submitter
- DIS3L p.Cys646Tyr Uncertain significance Single submitter
- DIS3L p.Cys657Tyr Uncertain significance Single submitter
- DIS3L p.Cys918Ser Uncertain significance Single submitter
- DIS3L p.Gln139Pro Uncertain significance Single submitter
- DIS3L p.Glu1006Gln Uncertain significance Single submitter
- DIS3L p.Glu24Gln Uncertain significance Single submitter
- DIS3L p.Glu327Gly Uncertain significance Single submitter
- DIS3L p.Glu440Ala Uncertain significance Single submitter
- DIS3L p.Glu615Ala Uncertain significance Single submitter
- DIS3L p.Glu871Asp Uncertain significance Single submitter
- DIS3L p.Glu970Asp Uncertain significance Single submitter
- DIS3L p.Gly422Glu Uncertain significance Single submitter
- DIS3L p.Gly552Ala Uncertain significance Single submitter
- DIS3L p.His280Gln Uncertain significance Single submitter
- DIS3L p.His290Leu Uncertain significance Single submitter
- DIS3L p.His57Tyr Uncertain significance Single submitter
- DIS3L p.His849Asn Uncertain significance Single submitter
- DIS3L p.His849Gln Uncertain significance Single submitter
- DIS3L p.Ile143Arg Uncertain significance Single submitter
- DIS3L p.Ile257Val Uncertain significance Single submitter
- DIS3L p.Ile396Ser Uncertain significance Single submitter
- DIS3L p.Ile518Thr Uncertain significance Single submitter
- DIS3L p.Ile629Val Uncertain significance Single submitter
- DIS3L p.Ile635Val Uncertain significance Single submitter
- DIS3L p.Ile897Thr Uncertain significance Single submitter
- DIS3L p.Leu1046Pro Uncertain significance Single submitter
- DIS3L p.Leu263Ile Uncertain significance Single submitter
- DIS3L p.Leu27Arg Uncertain significance Single submitter
- DIS3L p.Leu50Val Uncertain significance Single submitter
- DIS3L p.Lys1029Arg Uncertain significance Single submitter
- DIS3L p.Lys49Arg Uncertain significance Single submitter
- DIS3L p.Lys64Arg Uncertain significance Single submitter
- DIS3L p.Lys864Glu Uncertain significance Single submitter
- DIS3L p.Met162Thr Uncertain significance Single submitter
- DIS3L p.Met446Ile Uncertain significance Single submitter
- DIS3L p.Met538Leu Uncertain significance Single submitter
- DIS3L p.Met562Ile Uncertain significance Single submitter
- DIS3L p.Met861Val Uncertain significance Single submitter
- DIS3L p.Pro32Ser Uncertain significance Single submitter
- DIS3L p.Pro39Arg Uncertain significance Single submitter
- DIS3L p.Pro406Ala Uncertain significance Single submitter
- DIS3L p.Pro712Ser Uncertain significance Single submitter
- DIS3L p.Pro915Ser Uncertain significance Single submitter
- DIS3L p.Ser398Ala Uncertain significance Single submitter
- DIS3L p.Ser403Tyr Uncertain significance Single submitter
- DIS3L p.Ser53Arg Uncertain significance Single submitter
- DIS3L p.Ser569Thr Uncertain significance Single submitter
- DIS3L p.Ser988Asn Uncertain significance Single submitter
- DIS3L p.Ser994Asn Uncertain significance Single submitter
- DIS3L p.Thr368Ile Uncertain significance Single submitter
- DIS3L p.Thr426Ala Uncertain significance Single submitter
- DIS3L p.Thr680Ile Uncertain significance Single submitter
- DIS3L p.Tyr26His Uncertain significance Single submitter
- DIS3L p.Tyr372Cys Uncertain significance Single submitter
- DIS3L p.Tyr590His Uncertain significance Single submitter
- DIS3L p.Tyr792Cys Uncertain significance Single submitter
- DIS3L p.Val250Asp Uncertain significance Single submitter
- DIS3L p.Val293Leu Uncertain significance Single submitter
- DIS3L p.Val309Ile Uncertain significance Single submitter
- DIS3L p.Val334Leu Uncertain significance Single submitter
-
DIS3L p.Gly1030Glu
Uncertain significance
No assertion criteria
prostate cancer
Predictors split 72
The independent predictors disagree with each other — read with care.
- DIS3L p.Ala146Thr Uncertain significance Single submitter
- DIS3L p.Ala740Ser Uncertain significance Single submitter
- DIS3L p.Ala740Val Uncertain significance Single submitter
- DIS3L p.Arg17Ser Uncertain significance Single submitter
- DIS3L p.Arg242Cys Uncertain significance Single submitter
- DIS3L p.Arg242Leu Uncertain significance Single submitter
- DIS3L p.Arg333Gly Uncertain significance Single submitter
- DIS3L p.Arg343Gln Uncertain significance Single submitter
- DIS3L p.Arg378Gln Uncertain significance Single submitter
- DIS3L p.Arg395Cys Uncertain significance Single submitter
- DIS3L p.Arg395His Uncertain significance Single submitter
- DIS3L p.Arg412Cys Uncertain significance Single submitter
- DIS3L p.Arg534His Uncertain significance Single submitter
- DIS3L p.Arg535Cys Uncertain significance Single submitter
- DIS3L p.Arg535His Uncertain significance Single submitter
- DIS3L p.Arg637His Uncertain significance Single submitter
- DIS3L p.Arg643Gln Uncertain significance Single submitter
- DIS3L p.Arg707Cys Uncertain significance Single submitter
- DIS3L p.Arg734Trp Uncertain significance Single submitter
- DIS3L p.Arg756Gly Uncertain significance Single submitter
- DIS3L p.Arg759His Likely benign Single submitter
- DIS3L p.Arg809His Uncertain significance Single submitter
- DIS3L p.Arg873Cys Uncertain significance Single submitter
- DIS3L p.Asn251Ser Uncertain significance Single submitter
- DIS3L p.Asn498Thr Uncertain significance Single submitter
- DIS3L p.Asp389Asn Uncertain significance Single submitter
- DIS3L p.Asp661Asn Uncertain significance Single submitter
- DIS3L p.Asp68Asn Uncertain significance Single submitter
- DIS3L p.Asp68Tyr Uncertain significance Single submitter
- DIS3L p.Asp732His Uncertain significance Single submitter
- DIS3L p.Asp748Asn Uncertain significance Single submitter
- DIS3L p.Asp907Asn Uncertain significance Single submitter
- DIS3L p.Asp907Gly Uncertain significance Single submitter
- DIS3L p.Gln3Pro Uncertain significance Single submitter
- DIS3L p.Gln594Lys Uncertain significance Single submitter
- DIS3L p.Gln89Arg Uncertain significance Single submitter
- DIS3L p.Glu178Gly Uncertain significance Single submitter
- DIS3L p.Glu354Asp Uncertain significance Single submitter
- DIS3L p.Glu483Asp Uncertain significance Single submitter
- DIS3L p.Glu6Gln Uncertain significance Single submitter
- DIS3L p.Glu722Ala Uncertain significance Single submitter
- DIS3L p.Glu871Val Uncertain significance Single submitter
- DIS3L p.Glu970Lys Uncertain significance Single submitter
- DIS3L p.Gly418Arg Uncertain significance Single submitter
- DIS3L p.His200Leu Uncertain significance Single submitter
- DIS3L p.His25Arg Uncertain significance Single submitter
- DIS3L p.His839Tyr Uncertain significance Single submitter
- DIS3L p.Ile1040Arg Uncertain significance Single submitter
- DIS3L p.Ile377Leu Uncertain significance Single submitter
- DIS3L p.Ile417Thr Uncertain significance Single submitter
- DIS3L p.Ile505Val Uncertain significance Single submitter
- DIS3L p.Ile629Thr Uncertain significance Single submitter
- DIS3L p.Ile799Met Uncertain significance Single submitter
- DIS3L p.Ile840Thr Uncertain significance Single submitter
- DIS3L p.Ile875Val Uncertain significance Single submitter
- DIS3L p.Ile933Ser Uncertain significance Single submitter
- DIS3L p.Ile967Val Uncertain significance Single submitter
- DIS3L p.Leu229Val Uncertain significance Single submitter
- DIS3L p.Leu2Arg Uncertain significance Single submitter
- DIS3L p.Leu494Val Uncertain significance Single submitter
- DIS3L p.Lys672Met Uncertain significance Single submitter
- DIS3L p.Phe895Ser Uncertain significance Single submitter
- DIS3L p.Pro893Ser Uncertain significance Single submitter
- DIS3L p.Ser569Phe Uncertain significance Single submitter
- DIS3L p.Ser617Arg Uncertain significance Single submitter
- DIS3L p.Ser854Ala Uncertain significance Single submitter
- DIS3L p.Thr763Met Uncertain significance Single submitter
- DIS3L p.Thr944Met Uncertain significance Single submitter
- DIS3L p.Val1013Phe Uncertain significance Single submitter
- DIS3L p.Val367Ile Uncertain significance Single submitter
- DIS3L p.Val554Ile Uncertain significance Single submitter
- DIS3L p.Val8Met Uncertain significance Single submitter
All DIS3L variants
Likely benign 2
- p.Arg1026Cys Single submitter
- p.Arg759His Single submitter ⚠
Uncertain significance 152
- p.Ala146Thr Single submitter ⚠
- p.Ala362Val Single submitter ⚠
- p.Ala593Val Single submitter ⚠
- p.Ala693Thr Single submitter ⚠
- p.Ala740Ser Single submitter ⚠
- p.Ala740Val Single submitter ⚠
- p.Arg1026His Single submitter ⚠
- p.Arg1026Pro Single submitter ⚠
- p.Arg104Gln Single submitter ⚠
- p.Arg17Ser Single submitter ⚠
- p.Arg23Cys Single submitter ⚠
- p.Arg242Cys Single submitter ⚠
- p.Arg242Leu Single submitter ⚠
- p.Arg333Gly Single submitter ⚠
- p.Arg343Gln Single submitter ⚠
- p.Arg378Gln Single submitter ⚠
- p.Arg391Ser Single submitter ⚠
- p.Arg395Cys Single submitter ⚠
- p.Arg395His Single submitter ⚠
- p.Arg395Leu Single submitter ⚠
- p.Arg412Cys Single submitter ⚠
- p.Arg465Cys Single submitter ⚠
- p.Arg465Leu Single submitter ⚠
- p.Arg534His Single submitter ⚠
- p.Arg535Cys Single submitter ⚠
- p.Arg535His Single submitter ⚠
- p.Arg556Ser Single submitter ⚠
- p.Arg637His Single submitter ⚠
- p.Arg643Gln Single submitter ⚠
- p.Arg707Cys Single submitter ⚠
- p.Arg734Trp Single submitter ⚠
- p.Arg756Gly Single submitter ⚠
- p.Arg801Lys Single submitter ⚠
- p.Arg809His Single submitter ⚠
- p.Arg873Cys Single submitter ⚠
- p.Asn119Asp Single submitter ⚠
- p.Asn251Ser Single submitter ⚠
- p.Asn431Ile Single submitter ⚠
- p.Asn449Asp Single submitter ⚠
- p.Asn449His Single submitter ⚠
- p.Asn498Thr Single submitter ⚠
- p.Asp318Asn Single submitter ⚠
- p.Asp389Asn Single submitter ⚠
- p.Asp634Asn Single submitter ⚠
- p.Asp661Asn Single submitter ⚠
- p.Asp68Asn Single submitter ⚠
- p.Asp68Tyr Single submitter ⚠
- p.Asp732His Single submitter ⚠
- p.Asp748Asn Single submitter ⚠
- p.Asp907Asn Single submitter ⚠
- p.Asp907Gly Single submitter ⚠
- p.Asp916Glu Single submitter ⚠
- p.Cys646Tyr Single submitter ⚠
- p.Cys657Tyr Single submitter ⚠
- p.Cys918Ser Single submitter ⚠
- p.Gln139Pro Single submitter ⚠
- p.Gln3Pro Single submitter ⚠
- p.Gln594Lys Single submitter ⚠
- p.Gln89Arg Single submitter ⚠
- p.Glu1006Gln Single submitter ⚠
- p.Glu178Gly Single submitter ⚠
- p.Glu24Gln Single submitter ⚠
- p.Glu327Gly Single submitter ⚠
- p.Glu354Asp Single submitter ⚠
- p.Glu440Ala Single submitter ⚠
- p.Glu483Asp Single submitter ⚠
- p.Glu615Ala Single submitter ⚠
- p.Glu6Gln Single submitter ⚠
- p.Glu722Ala Single submitter ⚠
- p.Glu871Asp Single submitter ⚠
- p.Glu871Val Single submitter ⚠
- p.Glu970Asp Single submitter ⚠
- p.Glu970Lys Single submitter ⚠
- p.Gly418Arg Single submitter ⚠
- p.Gly422Glu Single submitter ⚠
- p.Gly552Ala Single submitter ⚠
- p.His200Leu Single submitter ⚠
- p.His25Arg Single submitter ⚠
- p.His280Gln Single submitter ⚠
- p.His290Leu Single submitter ⚠
- p.His57Tyr Single submitter ⚠
- p.His839Tyr Single submitter ⚠
- p.His849Asn Single submitter ⚠
- p.His849Gln Single submitter ⚠
- p.Ile1040Arg Single submitter ⚠
- p.Ile143Arg Single submitter ⚠
- p.Ile257Val Single submitter ⚠
- p.Ile377Leu Single submitter ⚠
- p.Ile396Ser Single submitter ⚠
- p.Ile417Thr Single submitter ⚠
- p.Ile505Val Single submitter ⚠
- p.Ile518Thr Single submitter ⚠
- p.Ile629Thr Single submitter ⚠
- p.Ile629Val Single submitter ⚠
- p.Ile635Val Single submitter ⚠
- p.Ile799Met Single submitter ⚠
- p.Ile840Thr Single submitter ⚠
- p.Ile875Val Single submitter ⚠
- p.Ile897Thr Single submitter ⚠
- p.Ile933Ser Single submitter ⚠
- p.Ile967Val Single submitter ⚠
- p.Leu1046Pro Single submitter ⚠
- p.Leu229Val Single submitter ⚠
- p.Leu263Ile Single submitter ⚠
- p.Leu27Arg Single submitter ⚠
- p.Leu2Arg Single submitter ⚠
- p.Leu494Val Single submitter ⚠
- p.Leu50Val Single submitter ⚠
- p.Lys1029Arg Single submitter ⚠
- p.Lys49Arg Single submitter ⚠
- p.Lys64Arg Single submitter ⚠
- p.Lys672Met Single submitter ⚠
- p.Lys864Glu Single submitter ⚠
- p.Met162Thr Single submitter ⚠
- p.Met446Ile Single submitter ⚠
- p.Met538Leu Single submitter ⚠
- p.Met562Ile Single submitter ⚠
- p.Met861Val Single submitter ⚠
- p.Phe895Ser Single submitter ⚠
- p.Pro32Ser Single submitter ⚠
- p.Pro39Arg Single submitter ⚠
- p.Pro406Ala Single submitter ⚠
- p.Pro712Ser Single submitter ⚠
- p.Pro893Ser Single submitter ⚠
- p.Pro915Ser Single submitter ⚠
- p.Ser398Ala Single submitter ⚠
- p.Ser403Tyr Single submitter ⚠
- p.Ser53Arg Single submitter ⚠
- p.Ser569Phe Single submitter ⚠
- p.Ser569Thr Single submitter ⚠
- p.Ser617Arg Single submitter ⚠
- p.Ser854Ala Single submitter ⚠
- p.Ser988Asn Single submitter ⚠
- p.Ser994Asn Single submitter ⚠
- p.Thr368Ile Single submitter ⚠
- p.Thr426Ala Single submitter ⚠
- p.Thr680Ile Single submitter ⚠
- p.Thr763Met Single submitter ⚠
- p.Thr944Met Single submitter ⚠
- p.Tyr26His Single submitter ⚠
- p.Tyr372Cys Single submitter ⚠
- p.Tyr590His Single submitter ⚠
- p.Tyr792Cys Single submitter ⚠
- p.Val1013Phe Single submitter ⚠
- p.Val250Asp Single submitter ⚠
- p.Val293Leu Single submitter ⚠
- p.Val309Ile Single submitter ⚠
- p.Val334Leu Single submitter ⚠
- p.Val367Ile Single submitter ⚠
- p.Val554Ile Single submitter ⚠
- p.Val8Met Single submitter ⚠
- p.Gly1030Glu No assertion criteria prostate cancer ⚠