Sugi Variant

Sugi Variant/DISP1

DISP1 — 484 ClinVar variants

All ClinVar germline DISP1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 314 flagged for review →

2 Pathogenic · 6 Likely pathogenic · 11 Conflicting · 39 Benign · 5 Benign/Likely benign · 97 Likely benign · 324 Uncertain significance

Full DISP1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 314

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors vs ClinVar 1

ClinVar calls these pathogenic, but the computational predictors lean tolerated — the highest-value review flag.

Predictors agree, ClinVar conflicts 7

ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.

Predictors lean, ClinVar uncertain 217

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification. · showing the 150 best-reviewed of 217

Predictors split 89

The independent predictors disagree with each other — read with care.

All DISP1 variants

Pathogenic 2

Likely pathogenic 6

Conflicting classifications of pathogenicity 11

Benign 39

Benign/Likely benign 5

Likely benign 97

Uncertain significance 324

Showing the top 300 by review status; the full set is in the sitemap.